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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Combination Assessment of Volume Status (CAVS)
Published Wednesday, May 17, 2023Early and aggressive fluid resuscitation in shock is associated with improved patient outcome and mortality. However, there is a clear correlation between cumulative fluid balance and mortality. There is, therefore, a benefit to adopting a systematic approach to fluid resuscitation to determine which patients would benefit from a fluid bolus...
Investigator(s): Sarah Murthi
Categories: Diagnostics, Software + Algorithm
Keyword(s): CAVS, shock, ultrasound, POCUS
Docket: SM-2016-067
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BLEEDING RISK INDEX (BRI) PREDICTION ALGORITHM
Published Monday, November 7, 2022Hemorrhage is the most common cause of preventable death on the battlefield and in civilian trauma care. Triaging patients that may have life-threatening bleeding in the field is essential for distinguishing those who need trauma center care, early control of bleeding, and blood transfusion. The UMB inventors developed the Bleeding Risk Index (...
Investigator(s): Peter Hu, Colin Mackenzie, Shiming Yang, Hegang Chen, Konstantinos Kalpakis
Categories: Software + Algorithm, Healthcare
Keyword(s): Clinical decision support; blood transfusion; triage
Docket: PH-2014-007; PH-2016-074
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Real-Time Critical-Care Patient Vital Signs Viewer System
Published Monday, November 7, 2022Our team of trauma care specialists at University of Maryland, Baltimore built the “Real-Time Critical-Care Patient Vital Signs Viewer System” (the “VS Viewer”) as a custom-designed physiological data display system that allows for bedside and remote monitoring of critically ill patients. In fact, the system has reliably been running...
Investigator(s): Peter Hu, Shiming Yang, Colin Mackenzie, Thomas Scalea, Lynn Stansbury, Deborah Stein
Categories: Software + Algorithm, Healthcare, Sensors/Monitors
Keyword(s): Trauma care; remote monitor; clinical decision support tool
Docket: PH-2012-076
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Noninvasive Characterization of Mechanical Properties of Materials and Tissue using Magnetic Resonance Techniques
Published Wednesday, February 6, 2019Many diseases alter the mechanical properties of tissue. Accordingly, the mechanical properties can serve as biomarkers for disease, diagnosis, and tumor assessment. While some larger diseased tissues or abnormalities near the surface of a patient can be detected by palpitation, many are located deep within the patient or too small to...
Investigator(s): Bruce Yu, Mark Taraban, Yue Feng
Categories: Devices, Software + Algorithm, Sensors/Monitors, Industrial Processing, Other
Keyword(s): MRI, NMR, diagnostic
Docket: BY-2012-013
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Automated evaluation of surgeon technical performance
Published Wednesday, November 15, 2017The technical skills of a surgical resident are typically evaluated by experienced mentors during training. However, this process is time-consuming, labor-intensive and may involve evaluator biases. In an effort to standardize such technical evaluations, UMB researchers developed an automated, sensor-free...
Investigator(s): Colin Mackenzie, Peter Hu, Shiming Yang, Evan Garofalo
Categories: Software + Algorithm, Education/Training/Multimedia
Keyword(s): surgery, education, assessments
Docket: CM-2016-014
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Image Analysis of Circulating Tumor Cell MicroTentacles
Published Wednesday, October 4, 2017The study of circulating tumor cells (CTC) is of considerable interest because of their prognostic value and for therapeutic development. One interesting morphological aspect of CTCs is the presence of microtentacles. Microtenticles are protusions found on the CTCs that are thought to be critically important for...
Investigator(s): Stuart Martin (UMB), Wolfgang Losert (UMCP)
Categories: Software + Algorithm
Keyword(s): software, assay, oncology
Docket: SM-2018-015
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A Data Visualization Tool to Explore Multidimensional Clinical Datasets
Published Monday, June 19, 2017WinnowTM is an innovative tool to efficiently sift through arrays of longitudinal data, identify patterns, generate hypotheses, and subject these hypotheses to rigorous statistical analysis. It has an intuitive, interactive and insightful platform- valuable to all...
Investigator(s): Lisa Shulman, MD ; Amitabh Varshney, PhD
Categories: Software + Algorithm, Healthcare, Information Technology, Genomics/Proteomics/Database
Keyword(s): Software; Algorithm; Healthcare; Information Technology; Data Analytics
Docket: LS-2017-024
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eLVOTD: Estimation of the Left Ventricular Outflow Tract Diameter
Published Monday, May 15, 2017The left ventricular outflow tract diameter (LVOTD) is one of two measurements needed to calculate cardiac stroke volume and cardiac output (CO). CO is an important measure of heart function and can help determine the need for inotropic support of the heart. In combination with mean arterial blood pressure, CO can also be used to determine the...
Investigator(s): Sarah Murthi
Categories: Diagnostics, Imaging, Software + Algorithm
Keyword(s): Acute care
Docket: SM-2017-060
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Balanced Reach Control Systems Model
Published Tuesday, May 2, 2017Bipedal standing balance is inherently unstable and must be actively controlled to prevent falling. This involves a complex interaction of the sensorimotor system and multi-segment musculoskeletal system. Fall risk increases with deterioration of sensorimotor and musculoskeletal elements responsible for balance due to age, neurological...
Investigator(s): Joseph E. Barton
Categories: Devices, Imaging devices, Software + Algorithm, Methods of Treatment
Keyword(s): Rehabilitation, balance, reaching, Aging Population
Docket: JB-2016-005, JB-2016-004
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Prompt Gamma Imaging System for Proton Range Verification using a Compton Camera
Published Tuesday, April 11, 2017Range uncertainty in the exact position of the distal dose gradient of a proton beam delivered within a patient during radiotherapy (RT) can lead to underdosing of the tumor or to excessive dosing to adjacent healthy tissues or critical organs at risk. The unwanted side effects and complications due this uncertainty is...
Investigator(s): Jerimy Polf, PhD
Categories: Devices, Imaging devices, Software + Algorithm, Healthcare
Keyword(s): Radiotherapy; medical imaging; prompt gamma; compton camera; range verification
Docket: JP-2015-137