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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Silicon Hydrogel Contact Lenses with Embedded Assay Components for Tear Fluid Clinical Assays
Published Wednesday, November 15, 2023Summary The "Silicon Hydrogel Contact Lenses with Embedded Assay Components for Tear Fluid Clinical Assays" patent describes an advancement in non-invasive medical diagnostics. It integrates clinical assay components into contact lenses for real-time tear fluid analysis, catering...
Investigator(s): Joseph R. Lakowicz, Ramachandram Badugu, E. Albert Reece
Categories: Imaging devices, Diagnostics, Biomarker, Healthcare
Keyword(s): non-invasive monitoring, clinical assays, biomarkers, medical diagnostics
Docket: JL-2021-074
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ANALYTE-SENSITIVE PROBES AND CONTACT LENS FOR DIAGNOSIS OF OCULAR PATHOLOGIES
Published Thursday, November 9, 2023Summary The patent introduces a contact lens integrated with analyte-sensitive probes for diagnosing ocular pathologies through the detection of specific analytes in basal tears. This non-invasive, real-time monitoring technology has applications in medical diagnostics and...
Investigator(s): Joseph R. Lakowicz, Ramachandram Badugu, E. Albert Reece
Categories: Devices, Imaging devices, Diagnostics, Imaging, Healthcare
Keyword(s): Analyte-sensitive probes, fluorescence, Diagnostics, Real-time monitoring
Docket: JL-2019-091
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Silicone Hydrogel Based Fluorescent Assay and Contact Lens
Published Wednesday, November 8, 2023Summary The "Silicone Hydrogel Based Fluorescent Assay and Contact Lens" patent introduces a novel technology for non-invasive medical diagnostics. It integrates a fluorescent assay into a silicone hydrogel contact lens, enabling real-time glucose monitoring in tear fluid. This...
Investigator(s): Joseph R. Lakowicz, Ramachandram Badugu, E. Albert Reece
Categories: Devices, Diagnostics, Biomarker
Keyword(s): fluorescent assay, Glucose Monitoring, analyte detection, biomarker monitoring, diabetes
Docket: JL-2016-128
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One Dimensional Photonic Crystals for Enhanced Fluorescence Based Sensing, Imaging and Assays
Published Monday, November 6, 2023Summary This patent presents a leap in photonic devices, using one-dimensional photonic crystals (1DPCs) to amplify fluorescence in biological assays. The innovation promises a thousand-fold enhancement of evanescent fields, tunable emission, and cost-effective production. It has...
Investigator(s): Joseph R. Lakowicz, Ramachandram Badugu
Categories: Diagnostics, Imaging
Keyword(s): Photonic crystals, fluorescence enhancement, Bloch Surface Waves, sensing, imaging, assays, dielectric materials, biomolecule detection, real-time quantification.
Docket: JL-2013-117
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DIAGNOSIS AND PROGNOSIS OF MULTIPLE SCLEROSIS
Published Tuesday, October 31, 2023Summary: The patent introduces a novel method for determining whether an individual with relapsing-remitting multiple sclerosis (RRMS) will experience a relapse or respond positively to specific treatments. By analyzing the ratio of mRNA levels of Response Gene to Complement-32...
Investigator(s): Horea Rus, Cornelia Cudrici, Cosmin Tegla
Categories: Diagnostics, Biomarker
Keyword(s): Multiple Sclerosis, Diagnosis, Prognosis
Docket: HR-2010-081, HR-2015-030
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Quaternary Nitrogen Heterocyclic Compounds for Detecting Aqueous Monosaccharides in Physiological Fluids
Published Wednesday, July 26, 2023QUATERNARY NITROGEN HETEROCYCLIC COMPOUNDS FOR DETECTING AQUEOUS MONOSACCHARIDES IN PHYSIOLOGICAL FLUIDS Summary WO2005000109 describes a novel glucose detection method that employs a glucose binding...
Investigator(s): Chris Geddes, Ramachandran Badugu, Joseph Lakowicz
Categories: Diagnostics
Keyword(s): diabetes, Glucose Monitoring
Docket: CG-2003-03
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Real Time in-situ Monitoring of Drug Product Degradation Using Water Proton NMR
Published Wednesday, May 17, 2023Summary This technology uses NMR spectroscopy to measure changes in the NMR signal of water, which is sensitive to changes in the chemical environment of the drug molecules it interacts with. This patented method allows for...
Investigator(s): Bruce Yu, Marc Taraban, Katharine Briggs
Categories: Devices, Diagnostics, Therapeutics, Small molecules, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze-Thaw
Docket: BY-2020-079
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Noninvasive Quantitation of Full Versus Empty Capsids Using Water Proton NMR
Published Wednesday, May 17, 2023Summary This invention proposes a method for using NMR relaxation rates to determine whether capsid preparations contain empty or full viral capsids and to quantify the capsid content of the preparation....
Investigator(s): Bruce Yu, Marc Taraban
Categories: Devices, Diagnostics, Therapeutics, Small molecules, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze Thaw
Docket: BY-2020-059
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In situ determination of alum filling evenness and sedimentation in pharmaceutical products using water NMR
Published Wednesday, May 17, 2023Summary The invention describes a fast and non-destructive technique to determine the evenness of alum particle filling levels and/or...
Investigator(s): Bruce Yu, Christopher Fox, Marc Taraban
Categories: Diagnostics, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing
Docket: BY-2019-021
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Solvent nuclear magnetic resonance for noninvasive inspection of particle-containing products
Published Wednesday, May 17, 2023Summary This patented technology uses solvent nuclear magnetic resonance (NMR) as a noninvasive method for quality control testing of particle products in both pharmaceuticals and non-pharmaceuticals. This technique is rapid,...
Investigator(s): Bruce Yu, Marc Taraban
Categories: Diagnostics, Industrial Processing, Other
Keyword(s): NMR, Pharmaceutical, food, nanoparticles, Quality Control, Counterfeit Detection
Docket: BY-2017-009