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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Real Time in-situ Monitoring of Drug Product Degradation Using Water Proton NMR
Published Wednesday, May 17, 2023Summary This technology uses NMR spectroscopy to measure changes in the NMR signal of water, which is sensitive to changes in the chemical environment of the drug molecules it interacts with. This patented method allows for...
Investigator(s): Bruce Yu, Marc Taraban, Katharine Briggs
Categories: Devices, Diagnostics, Therapeutics, Small molecules, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze-Thaw
Docket: BY-2020-079
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Noninvasive Quantitation of Full Versus Empty Capsids Using Water Proton NMR
Published Wednesday, May 17, 2023Summary This invention proposes a method for using NMR relaxation rates to determine whether capsid preparations contain empty or full viral capsids and to quantify the capsid content of the preparation....
Investigator(s): Bruce Yu, Marc Taraban
Categories: Devices, Diagnostics, Therapeutics, Small molecules, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze Thaw
Docket: BY-2020-059
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Detection of Pharmaceutical Product Freezing History using Water Proton NMR
Published Wednesday, May 17, 2023Summary Researchers at UMB have created an innovative method that employs water proton nuclear magnetic resonance (NMR) spectroscopy to detect the freezing history of pharmaceutical products. This technology compares the...
Investigator(s): Bruce Yu, Marc Traban, Katharine Briggs
Categories: Devices, Therapeutics, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze-Thaw
Docket: BY-2019-081
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In situ determination of alum filling evenness and sedimentation in pharmaceutical products using water NMR
Published Wednesday, May 17, 2023Summary The invention describes a fast and non-destructive technique to determine the evenness of alum particle filling levels and/or...
Investigator(s): Bruce Yu, Christopher Fox, Marc Taraban
Categories: Diagnostics, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing
Docket: BY-2019-021
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Solvent nuclear magnetic resonance for noninvasive inspection of particle-containing products
Published Wednesday, May 17, 2023Summary This patented technology uses solvent nuclear magnetic resonance (NMR) as a noninvasive method for quality control testing of particle products in both pharmaceuticals and non-pharmaceuticals. This technique is rapid,...
Investigator(s): Bruce Yu, Marc Taraban
Categories: Diagnostics, Industrial Processing, Other
Keyword(s): NMR, Pharmaceutical, food, nanoparticles, Quality Control, Counterfeit Detection
Docket: BY-2017-009
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Noninvasive Characterization of Mechanical Properties of Materials and Tissue using Magnetic Resonance Techniques
Published Wednesday, February 6, 2019Many diseases alter the mechanical properties of tissue. Accordingly, the mechanical properties can serve as biomarkers for disease, diagnosis, and tumor assessment. While some larger diseased tissues or abnormalities near the surface of a patient can be detected by palpitation, many are located deep within the patient or too small to...
Investigator(s): Bruce Yu, Mark Taraban, Yue Feng
Categories: Devices, Software + Algorithm, Sensors/Monitors, Industrial Processing, Other
Keyword(s): MRI, NMR, diagnostic
Docket: BY-2012-013
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Selective RARγ Ligand-loaded Nanoparticles for Manipulation of Targeted Bone Growth
Published Wednesday, June 27, 2018Imbalance in bone length, caused by congenital conditions or fractures, can result in progressive deformity and physical problems. To date, the only way to adjust these bone length problems are surgical procedures. UMB researchers have identified a nuclear retinoid receptor, RARγ, which controls the rate of transition from cartilage to...
Investigator(s): Masahiro Iwamoto, Michael Chorny
Categories: Therapeutics, Other
Keyword(s): Orthopedics, Therapeutics Drug Delivery System
Docket: MI-2017-124
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Method for Image Reconstruction of Moving Radionuclide Source Distributions
Published Monday, September 28, 2015Positron emission tomography (PET) is a functional imaging technique for studying biological processes in vivo for pre-clinical and clinical studies. PET compounds labelled with short-lived positron emitters are delivered to a subject (human, animals or plants). The raw PET scanning data is reconstructed...
Investigator(s): Mark Smith
Categories: Imaging, Software + Algorithm, Other
Keyword(s): PET, SPECT, Image reconstruction, nuclear medicine
Docket: MS-2009-091
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Immunotherapeutic Potential of Modified Lipooligosaccharides/Lipid A: A Platform for “Custom-designed Adjuvants”
Published Wednesday, November 12, 2014Lipid A, the hydrophobic anchor of lipopolysaccharide (LPS), can stimulate the innate immune system via Toll-like receptor 4/myeloid differentiation factor 2 (TLR4/MD2), leading to the release of inflammatory cytokines/chemokines and type I interferons. In turn, this response increases the host’s ability to eradicate a pathogen and supports...
Investigator(s): Robert K Ernst, Adeline Hajjar, Mark Pelletier
Categories: Platforms, Biologics, Vaccines, Biological, Vaccine, Other
Keyword(s): adjuvant, subunit vaccine, lipid A, platform, lipopolysaccharide, immunostimulation custom synthesis
Docket: RE-2012-067
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Peptide Additives to Enhance the Acceptance and Consumption of Baits by Rodents
Published Wednesday, May 28, 2014Rodenticides are used to control rodent pests in residential, industrial and agricultural settings. Neophobic responses to unfamiliar food types, micro-sampling and learned poison shyness are factors that reduce bait acceptance by target rodents, reducing their effectiveness. It has been shown that Rodents exhibit a...
Investigator(s): Steven Munger
Categories: Clean Technology, Other
Keyword(s): peptide, rodent, rodenticide, behavior
Docket: SM-2013-065