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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Use of Novel Sulfonamides to Inhibit the Growth of Prostate Cancer Cells and Tumors
Published Thursday, May 29, 2014According to the American Cancer Society, prostate cancer (PCA) is the most common type of cancer found in American men. Currently, the major therapy for PCA in both primary and advanced stages is androgen deprivation. This treatment exerts its effects on target tissue by either blocking androgen synthesis or preventing binding of androgens to...
Investigator(s): Vincent C. O. Njar, Puranik Purushottamachar
Categories: Therapeutics, Small molecules
Keyword(s): prostate cancer, cancer
Docket: VN-2007-026
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Use of ClyA Hemolysin for Protein Export and Vaccines
Published Thursday, May 29, 2014The UMB inventor has engineered a novel protein export system for efficiently producing recombinant protein from a host cell, constructed with a genetically stabilized expression plasmid incorporating the protein of interest fused to the ClyA hemolysin of Salmonella enterica serovar Typhi. Used in a live-vector vaccine, this system allows the...
Investigator(s): James Galen
Categories: Therapeutics, Vaccines
Docket: JG-2001-022
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University of Maryland, School of Dentistry OSCE Exam
Published Thursday, May 29, 2014Objective Structures Clinical Exams (OSCEs) are used in the assessment of health sciences professionals (e.g. orthoptics, optometry, medicine, nursing, pharmacy) to test clinical performance and competence in skills such as communication, clinical examination, medical procedures, prescription writing, radiographic...
Investigator(s): Judith A Porter, Doug Brotherton, Shabrez Ahmed, Karen Faraone, Edward G Grace, Cynthia L Idzik-Starr, Andrea M Morgan, Harlan Shiau
Categories: Software + Algorithm, Education/Training/Multimedia
Keyword(s): dental, clinical, exams
Docket: JP-2012-099
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Broad spectrum antibacterial therapeutic peptides of probiotic origin
Published Thursday, May 29, 2014Bacterial diarrhea still remains the second leading cause of deaths globally, accounting for one fifth of all deaths among children under five. Small bioactive peptides with both Gram-positive and Gram-negative bactericidal activity have been isolated from Lactobacillus GG. These peptides...
Investigator(s): Alessio Fasano, Ruiliang Lu
Categories: Therapeutics, Biologics
Keyword(s): diarrhea, pathogenic bacteria, peptides, probiotic, Lactobacillus, broad spectrum, biologics
Docket: SF-2006-008
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Total and Phosphorylated IL-1 Receptor-Associated Kinase-1 (IRAK-1) and -4 (IRAK-4) as a Biomarker for Cancer Progression and Chemotherapy Resistance.
Published Thursday, May 29, 2014UMB inventors have identified two proteins active in the TNF receptor-associated factor (TIRAF)/MyD88 pathway, Interleuken-1 Receptor-Associated Kinase (IRAK)-1 and -4, as potential targets for combinatorial therapy reducing chemotherapy resistance in multiple cancer cell lines. IRAK is a...
Investigator(s): Eduardo Davila
Categories: Therapeutics
Keyword(s): chemotherapy, cancer
Docket: ED-2012-072
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Thermostabilization of DNA Polymerase with Novel Chaperones
Published Thursday, May 29, 2014Dr. Frank Robb has considerable expertise in the study of microbes found in extreme environments and their mechanisms of survival. These astonishing organisms have protein chaperone systems that enable them to survive and even thrive in extreme heat and harsh chemical conditions. An important application for these chaperones is to enhance...
Investigator(s): Frank Robb, Pongpan Laksanalamai
Categories: Research Tools, Antibodies, & Reagents, Engineering, Chemical
Docket: FR-2010-087
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Techniques for Converting Analog Medical Video to Digital Objects
Published Thursday, May 29, 2014The present invention relates to converting analog medical video data to a digital object that associates descriptive data with the video, and in particular, to forming digital imaging and communications in medicine (DICOM) objects from analog medical video data in a legacy data collection system.
Investigator(s): Paul Nagy
Categories: Software + Algorithm, Healthcare
Keyword(s): medical, video, digital
Docket: PN-2006-047
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Targeting NAD biosynthesis in bacterial pathogens
Published Thursday, May 29, 2014The increasing incidence of antibiotic-resistant pathogens is a major health crisis, particularly in hospital settings in the developed world. It has been estimated that ~70% of hospital-acquired infections involve multi-antibiotic resistant organisms, resulting in ~90,000 annual deaths at a cost of 4.5ý6.0 billion per year (Burke, 2003)....
Investigator(s): Alexander J MacKerell, Hong Zhang, Andrea L Osterman
Categories: Therapeutics, Small molecules
Keyword(s): biosynthesis, pathogens
Docket: AM-2009-069
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Targeted Delivery of Imaging Probes for In Vivo Cellular Imaging
Published Thursday, May 29, 2014Electron paramagnetic resonance (EPR) imaging is a technique for studying molecules that have one or more unpaired electrons, such as organic and inorganic free radicals or complexes with a transition metal ion. EPR may be thought of as analogous to MRI, except that it measures the excitation of electron spins instead of atomic nuclei. Given...
Investigator(s): Joseph Kao, Gerald Rosen, Scott Burks
Categories: Research Tools, Antibodies, & Reagents, Diagnostics
Keyword(s): imaging
Docket: JK-2010-098
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Targeted Conditional Expression of Proteins to Cell-Type
Published Thursday, May 29, 2014Mitochondrial dysfunction has been implicated in the pathogenesis of a plethora of neurodegenerative disorders (e.g., stroke, Parkinson's, amyotrophic lateral sclerosis, Huntington's, Alzheimer's, etc.). However, effective models useful for elucidating mechanisms and therapies associated with neuronal mitochondrial dysfunction are lacking. This...
Investigator(s): Krish Chandrasekaran, Tibor Kristian
Categories: Research Tools, Antibodies, & Reagents
Docket: KC-2006-026