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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Cloward-style cervical cage with lateral stabilizers
Published Wednesday, June 28, 2023Summary The disclosed technology is a Cloward-style cervical mesh cage with lateral stabilizers, which is designed for anterior cervical fusion and fixation in spinal surgeries. The device comprises a cylindrical body made of mesh-like material, which is...
Investigator(s): Charles Sansur
Categories: Medical implants, Surgical devices
Keyword(s): Cervical Cage, Spinal Fusion, Spinal Implant
Docket: CS-2017-050
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Interbody Cage for Spinal Stabilization
Published Wednesday, June 28, 2023Summary The patented technology is an interbody cage designed for spinal stabilization. The cage is characterized by a frame surrounding a central compartment capable of retaining biological material, specifically bone grafts, during surgery. The global...
Investigator(s): Charles Sansur, Steven Ludwig
Keyword(s): Spinal Stabilization, Spinal Fusion, medical device, Orthopedic Surgery, Degenerative Disc Disease
Docket: CS-2016-080
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Water Proton NMR for Monitoring Sedimentation Process of Multiphase Mixtures
Published Tuesday, June 27, 2023Summary The technology developed by the University of Maryland, Baltimore utilizes water proton Nuclear Magnetic Resonance (NMR) to monitor the sedimentation process in multiphase mixtures in real-time. This analytical method...
Investigator(s): Bruce Yu, Marc Taraban
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Small molecules, Chemicals, Biologics, Vaccines
Keyword(s): Sedimentation Monitoring, Multiphase Mixtures, Water Proton NMR, Pharmaceutical, Specialty Chemical, Specialty Materials
Docket: BY-2020-149
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Muscarinic Antagonists for the Treatment of Depression
Published Monday, June 26, 2023Summary The disclosed technology describes the utilization of muscarinic antagonists for the treatment of depression. Muscarinic antagonists are a class of compounds that block muscarinic acetylcholine receptors to ameliorate...
Investigator(s): Andrew Coop, Jack Bergman, Chad Johnson, Brian Kangas, James Woods, Emily Jukiewicz, Gail Winger
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): depression, Muscarinic Antagonists, Mood Regulation
Docket: AC-2019-107
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System and method for automatic emergency airway detection
Published Thursday, May 25, 2023Summary The disclosed invention describes an innovative system designed to automatically detect emergency airways. The technology leverages advanced computing and sensor mechanisms to facilitate rapid and precise airway...
Investigator(s): Rajabrata Sarkar, Jeffrey S. Wolf, Aldo T. Iacono, Stephen Restaino, Riddhi Gopal
Keyword(s): Emergency Medicine, Airway Management, medical device, Automated System
Docket: RS-2016-058
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Peritoneal Oxygenation System and Method
Published Thursday, May 25, 2023Summary The disclosed invention describes a system and method that enables gas exchange in a patient's body cavity, such as the abdomen, independent of the lungs. This system uses an inert chemical, perfluorocarbon (PFC), to...
Investigator(s): Joseph Friedberg, Hosam Fathy, Jin-Oh Hahn, Mahsa Doosthosseini, Majid Aroom, Kevin Aroom
Keyword(s): Peritoneal Oxygenation, Respiratory Illnesses, Oxygenation Perfusion
Docket: JF-2020-108
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Hemofiltration device, system and method for a high blood flow extracorporeal circuit
Published Thursday, May 25, 2023Summary The disclosed invention describes a hemofiltration device, system, and method designed for high blood flow extracorporeal circuits. This technology overcomes the limitations of conventional renal replacement therapy (...
Investigator(s): Alison Grazioli, Joseph Rabin, Ronson Madathil, Rashmikant Shah
Categories: Devices, Methods of Treatment
Keyword(s): Hemofiltration, High Blood Flow, Extracorporeal Circuit, Renal Replacement Therapy
Docket: AG-2019-016
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Dual Wnt Signaling Pathway Inhibitors and AMPK Activators for Treatments of Disease
Published Wednesday, May 24, 2023Summary The technology presents a novel approach to treating diseases such as various types of cancer and metabolic diseases. Disclosed is a series of compounds that simultaneously inhibit the Wnt/beta-catenin pathway and...
Investigator(s): Fengtian Xue, Yan Shu, Yong Al
Categories: Therapeutics, Small molecules
Keyword(s): Wnt Signaling inhibitor, AMPK activators, cancer, Metabolic Disease, Therapeutic
Docket: FX-2021-051
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Gallium-salophen Antimicrobial Compounds and Methods of Use Thereof
Published Wednesday, May 24, 2023Summary Pseudomonas aeruginosa (Pa), a WHO priority 1 pathogen, causes life-threatening infections. Multidrug resistant Pa has been classified by the CDC as a “serious...
Investigator(s): Fengtian Xue, Angela Wilks
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): pharmaceuticals, Clinical Medicine, Antimicrobial Compounds
Docket: FX-2020-101
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Real Time in-situ Monitoring of Drug Product Degradation Using Water Proton NMR
Published Wednesday, May 17, 2023Summary This technology uses NMR spectroscopy to measure changes in the NMR signal of water, which is sensitive to changes in the chemical environment of the drug molecules it interacts with. This patented method allows for...
Investigator(s): Bruce Yu, Marc Taraban, Katharine Briggs
Categories: Devices, Diagnostics, Therapeutics, Small molecules, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze-Thaw
Docket: BY-2020-079