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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Optimized Shigella-ETEC Vaccine with Broad-Spectrum Protection
Published Friday, April 22, 2022UMB’s optimized Shigella-ETEC vaccine is designed to provide enhanced & essential protection against the clinically important species & serotypes of Shigella and Enterotoxigenic Escherichia coli (ETEC), the major causes of dehydrating diarrheal illness among children under 5 years old in low to middle-income countries...
Investigator(s): Eileen M. Barry & Myron M. Levine
Categories: Vaccines
Keyword(s): Vaccine; diarrheal disease prevention; travelers
Docket: EB-2018-077
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Method to Preserve Post-radiotherapy Ventilation by Mitigating Radiation-Induced Airway Injury
Published Tuesday, September 7, 2021Preserving post-radiotherapy respiratory function is an important consideration in thoracic radiation therapy. A common limitation of current clinical and investigational approaches that attempt to achieve this objective is that they ignore radiation injury to the elements of the bronchial tree, which are critical to the gas exchange...
Investigator(s): Amit Sawant; Esther Vicente; Arezoo Modiri; Robert Timmerman; Yulong Yan; Henky Wibowo
Categories: Imaging, Healthcare, Methods of Treatment
Keyword(s): Radiation Treatment Planning; Software; Imaging; Oncology; Cancer
Docket: AS-2019-095
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Live Attenuated Non-Transmissible (“LANT”) Vaccines
Published Wednesday, August 18, 2021Non-typhoidal Salmonella (“NTS”) infections are the leading cause of foodborne deaths worldwide, with ~ 80 million (86%) of human NTS infections estimated as foodborne [Majowicz et al, 2010 Clin Infect Dis]. Moreover, multiple outbreaks are reported due to contact with infected animals (e.g., poultry, pigs, cattle, and pets). The...
Investigator(s): Sharon Tennant and James Galen
Categories: Vaccines
Keyword(s): vaccine, salmonella, NTS, AMR
Docket: ST-2019-013
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Treating Optic Nerve Diseases with Neural Stem Cell Factors
Published Thursday, July 30, 2020The optic nerve lamina region (ONLR) is a small junctional region between the eye and optic nerve (ON), and is the primary damage site in age-related eye diseases, such as open angle glaucoma (OAG). Dr. Bernstein’s group at UMB discovered that the ONLR of both human and rodent contains an adult neural progenitor cell (NPC) niche, which...
Investigator(s): Steven Bernstein; Candace Kerr; Sally Temple
Categories: Therapeutics, Stem Cells
Keyword(s): Stem cell; eye disease; glaucoma
Docket: SB-2015-057
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Novel strategies for engineering foreign protein-encoding cassettes into bacterial chromosomal DNA
Published Thursday, November 21, 2019Loss of protein expression is a major problem in protein therapy and live vector vaccination, wherein loss of therapeutic dosage often results in treatment failure. Plasmid DNA, when used as a pharmaceutical agent, allows for real-time protein expression, but is easily lost during bacterial multiplication. In order to achieve sufficiently...
Investigator(s): James E Galen, Jin Yuan Wang
Categories: Vaccines
Keyword(s): vaccine
Docket: JG-2013-037
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Interbody Cage with Spill-free Biological Material Compartment
Published Wednesday, October 16, 2019Spine surgeons often require the use of interbody cages to facilitate corrections of spinal deformities and to promote bone fusion in the disc spaces in between vertebrae. Current interbody cages have cavities that can be packed with bone graft material. However, it is difficult to keep the bone graft material contained in the cage...
Investigator(s): Charles Sansur, Steven Ludwig
Categories: Devices, Medical implants, Surgical devices
Keyword(s): Neurology, Spine, Interbody Cage, Spine Fusion
Docket: CS-2016-080
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System and Method for Diagnosis, Monitoring, and Treatment of Obstructive Sleep Apnea
Published Monday, September 30, 2019Sleep Apnea treatment represents a $6 billion market in the United States. Current treatment methods suffer from poor compliance rates. The inventors have proposed a novel ultrasound device to diagnose and treat sleep apnea.
Investigator(s): Amal Isaiah, Jeffrey Wolf
Categories: Devices, Imaging devices, Diagnostics, Imaging, Methods of Treatment
Keyword(s): sleep apnea
Docket: AI-2018-039
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Targeting Protein Translation with Novel Small Molecules for Treating Pancreatic and Prostate Cancer
Published Sunday, June 2, 2019Medicinal chemists at UMB designed a family of novel small molecules which block key drivers of the protein translational complex by degrading MNK1/2 (i.e., mitogen-activated protein kinase (MAPK)-interacting kinase 1/2), thus inhibiting the activation of the eIF4E axis and inhibiting tumor growth. Lead...
Investigator(s): Vincent Njar, Puranik Purushottamachar, Andrew Kwegyir-Afful, Francis Murigi
Categories: Therapeutics, Small molecules
Keyword(s): oncology, Small molecule therapeutic
Docket: VN-2013-094
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Inhibition of L-Plastin Activity in Osteoclasts to Reduce Bone Loss
Published Monday, March 11, 2019Osteoclasts (OCs) are specialized cell types that develop a focused microenvironment where bone matrix degradation can occur for the process of bone resorption or bone breakdown. Bone breakdown by osteoclasts requires the formation of tight sealing zone or ring in order for efficient focal bone breakdown to occur. L-plastin (LPL) is a...
Investigator(s): Meenakshi Chellaiah
Categories: Therapeutics, Biologics
Keyword(s): osteoporosis bone loss peptide
Docket: MC-2015-066
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A Deformable Lung Motion Phantom
Published Friday, March 8, 2019Motion caused by patient breathing can limit the accuracy of the prescribed dose delivered during radiation therapy (RT) especially for cancers in the thorax and abdomen. Sophisticated respiratory motion prediction and real-time motion modeling have been clinically implemented to improve the accuracy and precision of the dose being delivered to...
Investigator(s): Amit Sawant, Maida Ranjbar, Pouya Sabouri, Carlo Repetto
Categories: Devices
Keyword(s): Radiation Oncology
Docket: AS-2018-044