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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Combination Assessment of Volume Status (CAVS)
Published Wednesday, May 17, 2023Early and aggressive fluid resuscitation in shock is associated with improved patient outcome and mortality. However, there is a clear correlation between cumulative fluid balance and mortality. There is, therefore, a benefit to adopting a systematic approach to fluid resuscitation to determine which patients would benefit from a fluid bolus...
Investigator(s): Sarah Murthi
Categories: Diagnostics, Software + Algorithm
Keyword(s): CAVS, shock, ultrasound, POCUS
Docket: SM-2016-067
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Biofilm Antigen-Based Diagnostic for Chronic Staph aureus Infection
Published Tuesday, August 2, 2022Chronic infections associated with implanted medical devices such as prosthetic joints are difficult to diagnose and treat due to biofilm formation by the causative pathogens. Bacterial infections often persist in the form of protective biofilms (65 - 80% of all infections), a mode of growth which reduces the effectiveness of the host immune...
Investigator(s): Rebecca Brady, Jennifer Kofonow, Timothy Vail, Jeffrey Leid, Janette Harro, & Mark Shirtliff
Categories: Diagnostics
Keyword(s): infection, diagnostic, prosthetic joint infection, Biofilm, Staphylococcus aureus
Docket: MS-2008-064
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System and Method for Diagnosis, Monitoring, and Treatment of Obstructive Sleep Apnea
Published Monday, September 30, 2019Sleep Apnea treatment represents a $6 billion market in the United States. Current treatment methods suffer from poor compliance rates. The inventors have proposed a novel ultrasound device to diagnose and treat sleep apnea.
Investigator(s): Amal Isaiah, Jeffrey Wolf
Categories: Devices, Imaging devices, Diagnostics, Imaging, Methods of Treatment
Keyword(s): sleep apnea
Docket: AI-2018-039
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Liquid Biopsy Test for Early Detection of Lung Cancer
Published Wednesday, May 23, 2018Low-dose computed tomography (LDCT) is recommended for annual screening by the US Preventive Services Task Force, and the test is reimbursed by Medicare (see below). LDCT is intended for early detection of cancer, but unfortunately has a high false-positive rate (i.e., it detects indeterminate pulmonary nodules (PNs), 96% of...
Investigator(s): Feng Jiang
Categories: Diagnostics
Keyword(s): oncology, Diagnostics
Docket: FJ-2016-076, FJ-2017-097
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A Method for Monitoring Cancer and for Regulation of Semaphorin 4D to Improve Cancer Immunotherapy Regimens
Published Monday, May 14, 2018The efficacy of current cancer immunotherapies has been limited by the response of immunosuppressive elements such as myeloid derived suppressor cells (MDSC) and T regulatory cells. Understanding the mechanism behind the suppression of antitumor immunity, and finding ways to revert it, should lead to improved cancer immunotherapy outcomes....
Investigator(s): Rania Younis
Categories: Diagnostics, Biomarker, Therapeutics
Keyword(s): Semaphorin 4D, immunotherapy, oncology, head and neck, cancer
Docket: RY-2015-129
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eLVOTD: Estimation of the Left Ventricular Outflow Tract Diameter
Published Monday, May 15, 2017The left ventricular outflow tract diameter (LVOTD) is one of two measurements needed to calculate cardiac stroke volume and cardiac output (CO). CO is an important measure of heart function and can help determine the need for inotropic support of the heart. In combination with mean arterial blood pressure, CO can also be used to determine the...
Investigator(s): Sarah Murthi
Categories: Diagnostics, Imaging, Software + Algorithm
Keyword(s): Acute care
Docket: SM-2017-060
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Use of Biomarkers for Assessing Differential Risk for Developing Heart Failure Phenotypes
Published Wednesday, April 5, 2017Left ventricular (LV) hypertrophy (LVH), most commonly due to chronic hypertensive heart disease, is associated with increased risk of developing depressed LV systolic function, heart failure (HF) and death. Routine cardiac imaging to screen for LVH in hypertensive patients is not recommended because...
Investigator(s): Christopher deFilippi, James de Lemos, Robert H. Christenson, Stephen L. Seliger
Categories: Diagnostics, Biomarker
Keyword(s): biomarker, heart failure, Diagnostics
Docket: CD-2014-098
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Method of Visualizing Drusen in the Eye
Published Thursday, October 27, 2016Drusen are yellow fatty protein deposits under the retina. The formation of drusen increases the risk of a person developing “dry” age-related macular degeneration (dry AMD). The inventor has previously disclosed in published work the surprising finding that these deposits contained tiny hydroxyapatite (HAP)...
Investigator(s): Richard Thompson, Imre Lengyel
Categories: Diagnostics, Imaging
Keyword(s): Ophthalmology, Geriatric, diagnostic
Docket: RT-2012-010, RT-2016-112
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Compositions and Methods for Determining the Likelihood of Appendicitis
Published Tuesday, August 25, 2015Appendicitis is a condition that is easily treated through the surgical removal of the appendix. However, delays in diagnosis beyond 24-36 hours from the start of symptoms can lead to an increased risk of mortality, morbidity, and costs due to complications. Diagnosis is complicated by the heterogeneous clinical presentation of...
Investigator(s): Anthony Sandler, Claire M. Fraser, Emmanuel Mongodin, Hope Jackson, Katherine Davenport, Steven L. Zeichner
Categories: Diagnostics, Biomarker, Genomics/Proteomics/Database
Keyword(s): Appendicitis, Appendix, Microbiota, bacteria
Docket: CF-2014-074
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Use of Omentin for Treatment and Prediction of Disease
Published Wednesday, January 28, 2015Obesity, especially accumulation of abdominal fat, is a risk factor for the development of type 2 diabetes and cardiovascular disease. More than one-third of US adults are considered to be obese. Omentin is an adipokine expressed and secreted from abdominal but not subcutaneous...
Investigator(s): Da-Wei Gong, Alan Shuldiner, John McLenithan, Rongze Yang
Categories: Research Tools, Antibodies, & Reagents, Diagnostics, Therapeutics, Biologics, Biomaterials
Keyword(s): omentin, diabetes, obesity, cardiovascular
Docket: DG-2002-013, DG-2007-087, DG-2009-093