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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Inhibitors of Cell Migration and Shape Changes by Inhibiting Cortactin and HS-1 Mediated Actin Polymerization
Published Wednesday, May 28, 2014The present invention is a novel approach to suppress metastasis by targeting cortactin (or HS-1), an actin -associated protein. Cortactin is overexpressed in breast cancer and head and neck carcinomas where it plays a major role in tumor progression by promoting metastasis. Preventing binding of cortactin (or HS-1) to Arp2/3 blocks actin...
Investigator(s): Xi Zhan, Takehito Uruno
Categories: Therapeutics, Small molecules
Keyword(s): neck carcinomas, head carcinomas, cancer
Docket: XZ-2005-108
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Antimicrobial Heme Oxygenase Inhibitors and Methods of Use
Published Tuesday, May 27, 2014Antimicrobials are widely used to treat a variety of infections. However, due to overuse and microbial evolution, many antimicrobials are rendered ineffective as first-line therapies. This invention is a new class of broad-spectrum, small-molecule antimicrobials that target the critical enzyme, heme oxygenase that is required to process...
Investigator(s): Angela Wilks, Alexander D. MacKerell, Pedro Lopes, Lena M. Furci
Categories: Therapeutics, Small molecules
Keyword(s): antimicrobial, treatment
Docket: AW-2007-003
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New Treatments for Viral Diseases
Published Thursday, March 6, 2008Human viral epidemics have proliferated since the latter half of the 20th century. The same cannot be said of the medicines used to treat them. As HIV spreads to nearly every corner of the world, existing antivirals cannot fill the global need for inexpensive, easily accessible forms of treatment. New and potentially helpful drugs face a long and...
Categories: Small molecules, Therapeutics, Repurpose Drug
Keyword(s): Viral therapy, antibiotic
Docket: LS-2007-092
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