Search Technologies
Displaying 91 - 100 of 226 results
Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
Search by keyword:
-
Rational Targeting of Protein Translation in Cancer Cells
Published Wednesday, June 14, 2017Deregulation of protein translation is associated with a growing number of human diseases, including tumorigenesis. The mammalian mTOR pathway has garnered considerable interest as a major target for new anti-cancer therapies due to its key role in regulating cell growth. However, clinical applications have been limited due to the role of this...
Investigator(s): France Carrier
Categories: Therapeutics
Keyword(s): oncology, mROR
Docket: FC-2015-047
-
New Compounds to Treat Metastatic and Triple Negative Breast Cancer
Published Wednesday, May 31, 2017Despite multi-modal treatment, approximately 40% of all women with breast cancer will suffer a recurrence. While the 10-year overall survival rate for women without recurrence is 84%, this drops to 49%-72% for women with a locoregional recurrence or a second primary malignancy. Luminal breast cancer has the highest rates of relapse, often...
Investigator(s): Antonino Passaniti, Alexander MacKerell
Categories: Therapeutics, Small molecules
Keyword(s): breast cancer, oncolytic, small molecule, CADD
Docket: AP-2015-080
-
Irreversible Inhibitors of Type II Transglutaminase
Published Thursday, May 25, 2017Cancer stem cells (CSC) comprise a subpopulation of tumor cells that are slow-cycling, express stem cell markers, display enhanced migratory potential, undergo epithelial-mesenchymal transition (EMT), and form rapidly growing and highly vascularized and aggressive tumors. CSC often survive conventional cancer therapy and proceed to form rapidly...
Investigator(s): Abdullah Akbar, Gail Johnson, Jeffrey Keillor, Matthew Fisher, Richard Eckert
Categories: Small molecules
Keyword(s): Therapeutic, cancer, Cancer Stem Cells
Docket: RE-2016-066
-
Dichloroacetate and Arsenic Trioxide as an Acute Myeloid Leukemia Combination Therapy
Published Tuesday, May 16, 2017UMB research has been directed at a synergistic combination drug formulation of dichloroacetate and arsenic trioxide to treat AML. AML cells, compared to normal cells, have an increased susceptibility to the disruption of balance of oxidative forces. Selective targeting of the oxidative state, which is a tightly balanced...
Investigator(s): Ashkan Emadi, MD; Rena Lapidus, PhD
Categories: Repurpose Drug, Methods of Treatment
Keyword(s): AML; Acute Myeloid Leukemia; Combination Therapy; Arsenic Trioxide
Docket: AE-2013-045
-
eLVOTD: Estimation of the Left Ventricular Outflow Tract Diameter
Published Monday, May 15, 2017The left ventricular outflow tract diameter (LVOTD) is one of two measurements needed to calculate cardiac stroke volume and cardiac output (CO). CO is an important measure of heart function and can help determine the need for inotropic support of the heart. In combination with mean arterial blood pressure, CO can also be used to determine the...
Investigator(s): Sarah Murthi
Categories: Diagnostics, Imaging, Software + Algorithm
Keyword(s): Acute care
Docket: SM-2017-060
-
Balanced Reach Control Systems Model
Published Tuesday, May 2, 2017Bipedal standing balance is inherently unstable and must be actively controlled to prevent falling. This involves a complex interaction of the sensorimotor system and multi-segment musculoskeletal system. Fall risk increases with deterioration of sensorimotor and musculoskeletal elements responsible for balance due to age, neurological...
Investigator(s): Joseph E. Barton
Categories: Devices, Imaging devices, Software + Algorithm, Methods of Treatment
Keyword(s): Rehabilitation, balance, reaching, Aging Population
Docket: JB-2016-005, JB-2016-004
-
Inhibition of Galectin 3 Binding to the Airway Epithelial Surface to Treat or Prevent Septic Shock Resulting from Influenza and Subsequent Pneumococcal Pneumonia Infection
Published Tuesday, May 2, 2017The main cause of death during influenza pandemics is Streptococcus pneumoniae co-infection, which results in hyperinflammatory response leading to sepsis. While the exact mechanism behind this complication is not understood, influenza infection predisposes patients to pneumococcal pneumonia that often progresses to uncontrolled...
Investigator(s): Gerardo R. Vasta, Lai-Xi Wang
Categories: Therapeutics
Keyword(s): sepsis, influenza, antiinflammatory
Docket: GV-2015-133
-
Stable Fluorescent Mutant of Perkinsus marinus Expressing GFP
Published Tuesday, May 2, 2017Perkinsus are intracellular parasites that cause disease in shellfish, especially bivalve molluscs. Its infection has devastated oyster populations along the US coasts. In addition to the economic value of shellfisheries, filter-feeding bivalves such as oysters play a critical role in maintaining water quality, making Perkinsus...
Investigator(s): Gerardo R. Vasta, Jose-Antonio Fernandez-Robledo
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): Transgenic, protozoan
Docket: GV-2014-015
-
Prompt Gamma Imaging System for Proton Range Verification using a Compton Camera
Published Tuesday, April 11, 2017Range uncertainty in the exact position of the distal dose gradient of a proton beam delivered within a patient during radiotherapy (RT) can lead to underdosing of the tumor or to excessive dosing to adjacent healthy tissues or critical organs at risk. The unwanted side effects and complications due this uncertainty is...
Investigator(s): Jerimy Polf, PhD
Categories: Devices, Imaging devices, Software + Algorithm, Healthcare
Keyword(s): Radiotherapy; medical imaging; prompt gamma; compton camera; range verification
Docket: JP-2015-137
-
Use of Biomarkers for Assessing Differential Risk for Developing Heart Failure Phenotypes
Published Wednesday, April 5, 2017Left ventricular (LV) hypertrophy (LVH), most commonly due to chronic hypertensive heart disease, is associated with increased risk of developing depressed LV systolic function, heart failure (HF) and death. Routine cardiac imaging to screen for LVH in hypertensive patients is not recommended because...
Investigator(s): Christopher deFilippi, James de Lemos, Robert H. Christenson, Stephen L. Seliger
Categories: Diagnostics, Biomarker
Keyword(s): biomarker, heart failure, Diagnostics
Docket: CD-2014-098