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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Recombinant, Purified P. aeruginosa HemO Enzyme
Published Wednesday, April 5, 2017Pathogenic bacteria require iron for their survival and ability to cause infection. Many bacterial pathogens have evolved sophisticated systems to use heme as a primary source of iron, including Pseudomonas aeruginosa, an opportunistic gram-negative pathogen that is a common cause of nosocomial infections and associated with high...
Investigator(s): Angela Wilks
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): Heme oxygenase, heme O, TRP, Research Tool
Docket: AW-2015-091
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Surrogate-Based Prediction Model for Real-Time Tumor Monitoring during Radiotherapy
Published Friday, March 31, 2017To ensure tumor-targeting accuracy over the course of radiation treatment while minimizing the dosimetric impact to healthy tissue, respiratory surrogate models are utilized to monitor tumor position while compensating for tumor motion. These models are developed from a training dataset of concurrent tumor positions and...
Investigator(s): Warren D’Souza PhD
Categories: Software + Algorithm, Healthcare, Methods of Treatment
Keyword(s): radiology; medical imaging; image-guided radiation therapy
Docket: WD-2010-069
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Transgenic Ubiquitin (hUBQLN2) Mice Models of Amyotrophic Lateral Sclerosis with Frontotemporal Dementia (ALS-FTD)
Published Monday, March 6, 2017ALS (or Lou Gehrig’s disease) is a progressive neurodegenerative disorder associated with loss of upper and lower motor neurons. A majority of ALS patients (> 90%) die within 2 to 5 years of being diagnosed, usually because of upper respiratory failure. In addition to the hallmark of progressive muscle weakness, up to 15% of patients with...
Investigator(s): Mervyn J. Monteiro
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): Molecular Biology; Neuroscience; Genetics; Transgenic mice
Docket: MM-2017-037
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Nano-structured Metal-Enhanced Fluorescence (MEF-spot)-Based Sensing, Imaging and Assay
Published Friday, February 24, 2017This invention describes an improved method for conducting a bioassay using fluorescence intensity or lifetime fluorescent emissions. This new method avoids the need of complex enzymatic and biochemical amplification of the fluorescence signal. Although it has applicability over a wide range of bioassays, the method...
Investigator(s): Henryk Szmacinski, Joseph R. Lakowicz
Categories: Research Tools, Antibodies, & Reagents, Sensors/Monitors
Keyword(s): Cytokine assay, immunoassay
Docket: HS-2012-047, HS-2015-098
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Correction of Ischemia with p53 Inhibitors: A Novel Therapeutic Approach to Induce Arteriogenesis
Published Friday, February 24, 2017Severe obstruction of the arteries and reduced blood flow (critical limb ischemia(CLI)) is the advanced stage of peripheral artery disease (PAD). Investigators at UMB have found that Pifithrin-α, a p53 pharmacological inhibitor, improves limb perfusion in diabetic animals, suggesting a therapeutic role in CLI. Tumor-suppressing...
Investigator(s): Rajabrata Sarkar, Mark Hoofnagle, Subhradip Mukhopadhyay
Categories: Therapeutics, Methods of Treatment
Keyword(s): cardiovascular
Docket: RS-2013-040
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Surgical Drain Sutured-in-Place Prevention Kit
Published Thursday, February 23, 2017After a surgical procedure, a surgical drain is placed within the operative field for proper postoperative drainage of fluids. Complications occur when the sutures used to close the wound encircle or capture the drain, sewing the drain into the patient. Currently, there is no method to assure that a drain is not sewn...
Investigator(s): Douglas J. Turner
Categories: Surgical devices
Keyword(s): Surgical drain
Docket: DT-2013-129
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Nanoparticle-Based Artificial Antigen Presenting Cell for the Modulation of Natural Killer T (NKT) Cells
Published Thursday, February 23, 2017Natural killer T (NKT) cells constitute an important subset of T cells that can both, directly and indirectly, mediate antitumor immunity. It has been reported that the number of NKT cells in cancer patients can be 47% lower than those found in healthy patients. An effective mean of generating populations of NKT cells would be therapeutically...
Investigator(s): Tonya Webb, James East, Carolyn Morris
Categories: Nanotechnology + Nanoparticles + Nanomaterials
Keyword(s): Cancer Immunotherapy, adaptive immunotherapy
Docket: TW-2012-105
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Individually Optimized Uniform Enhancement in Contrast Enhanced Computed Tomography (CT) Scans
Published Thursday, February 23, 2017CT has become the primary method for to evaluate for pulmonary embolism (PE). However for CT to be diagnostic, uniform contrast enhancement of the pulmonary arterial tree is desired. Obtaining uniform contrast enhancement is difficult because there are numerous factors involved. There are methods for calculating the correct injection rate for...
Investigator(s): Ming Xue, Hao Howard Zhang, Seth Kligerman, Warren D. D’Souza, Wei Lu, Wookjin Choi
Categories: Software + Algorithm
Keyword(s): radiology
Docket: MX-2013-110
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Delay Belt Device: A Fall Prevention System
Published Thursday, February 23, 2017Injuries related to falls are a major source of morbidity and mortality and come with a significant financial burden to the health care system. This technology, a delay belt device (DBD) with electronic control features, provides a straightforward and complete solution to this problem. The DBD is an integrated electronic safety device that can...
Investigator(s): Michael Makley
Categories: Devices
Keyword(s): Healthcare device
Docket: MM-2012-077
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Protein-Repellant Compositions to Inhibit Protein Absorption and Bacteria Attachment for Dental Applications
Published Thursday, February 23, 2017The mechanism underlying dental caries is demineralization through the attack by acid generated by acidogenic bacteria. Acidogenic bacteria growth typically occurs in plaque and biofilm. When biofilms forms at the tooth restoration margins, the demineralization of the enamel and dentin leads to secondary caries, restorative material fractures,...
Investigator(s): Huakun Xu, Ning Zhang
Categories: Medical implants, Dental
Keyword(s): Dental devices, Antibacterial materials
Docket: HX-2014-154