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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Water Proton NMR for Monitoring Sedimentation Process of Multiphase Mixtures
Published Tuesday, June 27, 2023Summary The technology developed by the University of Maryland, Baltimore utilizes water proton Nuclear Magnetic Resonance (NMR) to monitor the sedimentation process in multiphase mixtures in real-time. This analytical method...
Investigator(s): Bruce Yu, Marc Taraban
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Small molecules, Chemicals, Biologics, Vaccines
Keyword(s): Sedimentation Monitoring, Multiphase Mixtures, Water Proton NMR, Pharmaceutical, Specialty Chemical, Specialty Materials
Docket: BY-2020-149
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Real Time in-situ Monitoring of Drug Product Degradation Using Water Proton NMR
Published Wednesday, May 17, 2023Summary This technology uses NMR spectroscopy to measure changes in the NMR signal of water, which is sensitive to changes in the chemical environment of the drug molecules it interacts with. This patented method allows for...
Investigator(s): Bruce Yu, Marc Taraban, Katharine Briggs
Categories: Devices, Diagnostics, Therapeutics, Small molecules, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze-Thaw
Docket: BY-2020-079
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Noninvasive Quantitation of Full Versus Empty Capsids Using Water Proton NMR
Published Wednesday, May 17, 2023Summary This invention proposes a method for using NMR relaxation rates to determine whether capsid preparations contain empty or full viral capsids and to quantify the capsid content of the preparation....
Investigator(s): Bruce Yu, Marc Taraban
Categories: Devices, Diagnostics, Therapeutics, Small molecules, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze Thaw
Docket: BY-2020-059
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Detection of Pharmaceutical Product Freezing History using Water Proton NMR
Published Wednesday, May 17, 2023Summary Researchers at UMB have created an innovative method that employs water proton nuclear magnetic resonance (NMR) spectroscopy to detect the freezing history of pharmaceutical products. This technology compares the...
Investigator(s): Bruce Yu, Marc Traban, Katharine Briggs
Categories: Devices, Therapeutics, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze-Thaw
Docket: BY-2019-081
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Vaccines Against ETEC with Isolation and Characterization of the csa Operon (ETEC-CS4 Pili)
Published Thursday, May 29, 2014Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea in infants and young children in developing countries, accounting for a high rate of infantile morbidity and mortality, and is also a major cause of traveler's diarrhea. Following ingestion of contaminated food or water containing ETEC, the bacteria can attach to the small...
Investigator(s): Zeev Altboum, Myron Levine, Eileen Barry
Categories: Therapeutics, Vaccines
Keyword(s): vaccine, diarrheal
Docket: ZA-2000-053
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Use of ClyA Hemolysin for Protein Export and Vaccines
Published Thursday, May 29, 2014The UMB inventor has engineered a novel protein export system for efficiently producing recombinant protein from a host cell, constructed with a genetically stabilized expression plasmid incorporating the protein of interest fused to the ClyA hemolysin of Salmonella enterica serovar Typhi. Used in a live-vector vaccine, this system allows the...
Investigator(s): James Galen
Categories: Therapeutics, Vaccines
Docket: JG-2001-022
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Strategy for a Broad-Spectrum Vaccine Against Non-Typhoidal Salmonella
Published Thursday, May 29, 2014On screening sub-Saharan African residents over the last decade for signs of invasive bacterial infection, a high incidence of non-typhoidal Salmonella (NTS) infections was discovered, and these cases were associated with antibiotic resistance and a high mortality of 20-30%. The invasive strains of NTS are dominated by Salmonella Typhimurium...
Investigator(s): Myron Levine, Sharon Tennant, Raphael Simon, James Galen
Categories: Therapeutics, Vaccines
Keyword(s): salmonella, vaccine
Docket: ML-2009-033
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Plasmid maintenance system for antigen delivery
Published Wednesday, May 28, 2014For live bacterial vaccines, various plasmid-based expression technologies may be utilized to express foreign antigens from the host bacteria. Keys to success using such systems include the need to achieve adequate antigen production to generate a good immune response, while reducing toxicity that may be associated with the foreign protein, and...
Investigator(s): James Galen
Categories: Therapeutics, Vaccines
Keyword(s): vaccine
Docket: JG-98-002
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PSA peptides for prostate cancer immunotherapy
Published Wednesday, May 28, 2014Prostate Specific Antigen (PSA) is a protein produced solely by prostate tissue, including tumors, and is considered a promising target for development of a prostate cancer vaccine. In fact, other groups are currently developing candidate vaccines focused on Class I-restricted CD8+ T-cell immunity, but the ultimate success of those efforts is...
Investigator(s): Richard Alexander, Elena Klyushnenkova, Arthur Vandenbark, Jason Link
Categories: Therapeutics, Biologics, Vaccines
Keyword(s): prostate cancer
Docket: RA-2004-035
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Multivalent Vaccine Against Staphylococcus Aureus
Published Wednesday, May 28, 2014There are nearly 2 million healthcare-associated infections in the U.S. per year, according to CDC-reported statistics. Many of these infections are due to colonization of implantable medical devices with drug-resistant forms of bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). The increasing incidence, morbidity and...
Investigator(s): Mark E. Shirtliff, Jan M. Harro, Jeffrey G. Leid, Rebecca Brady, Graeme O'May
Categories: Therapeutics, Vaccines
Keyword(s): vaccine, staph, Biofilm, MRSA
Docket: MS-2012-065