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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Real-time tracking of tumor motion during radiation treatment using a dynamic couch
Published Thursday, May 29, 2014A patient couch is designed to track movement of a target tumor in the patient (due to biological functions such as respiration), and to make compensatory moves so that the radiation treatment site is stabilized.
Investigator(s): Warren DýSouza, Xinsheng Yu, Mohan Suntharali, William Regine
Categories: Devices, Imaging devices
Keyword(s): radiation, tumor
Docket: WD-2005-055
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Radiology Protocoler
Published Thursday, May 29, 2014The Radiology Protocoler is a centralized, web-based system for automatically tracking, editing, and storing existing medical radiology documents and files both automatically and on demand. The web-based design allows the system to be accessed from within a hospital, radiology practice, or through a virtual private network (VPN). Modularity...
Investigator(s): Ross Filice, Wayne LaBelle
Categories: Software + Algorithm
Keyword(s): radiology, software
Docket: RF-2010-078
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Prostaglandin D2 metabolites for treatment of optic nerve diseases
Published Wednesday, May 28, 2014Blockage of blood supply to part or all of the optic nerve within the eye can lead to death or dysfunction of optic nerve cells and is termed non-arteritic ischemic optic neuropathy (NAION). NAION is the most common cause of sudden optic nerve related vision loss and affects about 10,000 Americans every year. Currently there is no effective,...
Investigator(s): Steven Lance Bernstein
Categories: Therapeutics, Biologics
Keyword(s): eye, Ophthalmology, stroke, ischemia, neuroprotection, orphan
Docket: SB-2008-026
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Pluripotent Stem Cell Production Method
Published Wednesday, May 28, 2014One of the major hurdles in stem cell research is that techniques for purification and propagation can be tedious and result in low yields. Standard methods require feeder cells, matrix, and serum, which are expensive and can introduce contaminants. UMB researchers, however, have developed an alternative method to consistently and reliably...
Investigator(s): G. David Trisler, Bernard M. Pessac, Christopher T. Bever Jr., James E. Goolsby
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Stem Cells
Keyword(s): stem cell
Docket: GT-2004-009
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Plasmid maintenance system for antigen delivery
Published Wednesday, May 28, 2014For live bacterial vaccines, various plasmid-based expression technologies may be utilized to express foreign antigens from the host bacteria. Keys to success using such systems include the need to achieve adequate antigen production to generate a good immune response, while reducing toxicity that may be associated with the foreign protein, and...
Investigator(s): James Galen
Categories: Therapeutics, Vaccines
Keyword(s): vaccine
Docket: JG-98-002
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Peptide Additives to Enhance the Acceptance and Consumption of Baits by Rodents
Published Wednesday, May 28, 2014Rodenticides are used to control rodent pests in residential, industrial and agricultural settings. Neophobic responses to unfamiliar food types, micro-sampling and learned poison shyness are factors that reduce bait acceptance by target rodents, reducing their effectiveness. It has been shown that Rodents exhibit a...
Investigator(s): Steven Munger
Categories: Clean Technology, Other
Keyword(s): peptide, rodent, rodenticide, behavior
Docket: SM-2013-065
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PSA peptides for prostate cancer immunotherapy
Published Wednesday, May 28, 2014Prostate Specific Antigen (PSA) is a protein produced solely by prostate tissue, including tumors, and is considered a promising target for development of a prostate cancer vaccine. In fact, other groups are currently developing candidate vaccines focused on Class I-restricted CD8+ T-cell immunity, but the ultimate success of those efforts is...
Investigator(s): Richard Alexander, Elena Klyushnenkova, Arthur Vandenbark, Jason Link
Categories: Therapeutics, Biologics, Vaccines
Keyword(s): prostate cancer
Docket: RA-2004-035
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Novel multidrug resistance transporter isolated from human breast cancer cells.
Published Wednesday, May 28, 2014The ATP binding cassette (ABC) transporters are the largest family of transmembrane proteins and involved in conferring multidrug resistance (MDR) to cancers, often causing the failure of cancer treatments. The discovery of Breast Cancer Resistance Protein (BCRP)/...
Investigator(s): Douglas Ross, Doyle L. Austin, Lynne Abruzzo
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): breast cancer, cancer, BCRP, chemotherapy
Docket: DR-97-047
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Novel Opioid Analgesics With Reduced Tolerance
Published Wednesday, May 28, 2014UMB 425 is a novel opioid with bi-functional activity that combines a delta-opioid antagonist and a mu-opioid agonist in a single compound with antinociceptive effects comparable to morphine. With reduced tolerance liabilities, UMB 425 provides a novel therapeutic approach in the treatment of patients who suffer from chronic pain with...
Investigator(s): Andrew Coop, Alexander MacKerell, Rae R. Matsumoto
Categories: Therapeutics, Small molecules
Keyword(s): Opioid, tolerance, analgesic
Docket: AC-2013-055
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Novel Filamentous Hyperstable Chaperone with Protein and Cellular Stabilization
Published Wednesday, May 28, 2014Ethanol, butanol, acetone and many other chemicals have traditionally been employed as a chemical feed stock for a variety of industrial chemicals. However, many of the byproducts produced during fermentation is cytotoxic and limits product generation. The disadvantages of low productivity, low cell density, longer fermentation, and prolonged...
Investigator(s): Frank Robb, Pongpan Laksanalamai, Anchalee Jiemjit, Douglas Clark, Timothy Whitehead
Categories: Engineering, Chemical
Docket: FR-2010-088