Search Technologies
Displaying 181 - 190 of 226 results
Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
Search by keyword:
-
Novel Alternatively Spliced Human Androgen Receptor Variants as Biomarkers for Prostate Cancer
Published Wednesday, May 28, 2014Prostate cancer is the second leading cause of cancer death among men in western countries. Patients with advanced prostate cancer initially benefit from androgen ablation therapy which leads to temporary remission of the tumor due to apoptosis of androgen-sensitive tumor cells. However, the recurrence of androgen-independent tumors is...
Investigator(s): Yun Qiu, Zhiyong Guo, Xi Yang
Categories: Diagnostics
Keyword(s): prostate cancer, biomarker, cancer
Docket: YQ-2008-056
-
Natural TFD-Containing Compound Prevents Tumorigenesis
Published Wednesday, May 28, 2014In 2011, prostate cancer was the second leading cause of cancer deaths in men and accounted for approximately a third of all new cases of cancer in the United States. Hormone therapy is the treatment of choice in cases where the primary tumor has metastasized or has advanced to a high-grade, high-risk disease. However, alternative strategies...
Investigator(s): Hafiz Ahmed, Prasan Guha, Engin Kaptan, Gerardo R. Vasta, Gargi Benerjee
Categories: Therapeutics
Keyword(s): natural products
Docket: HA-2011-053
-
NON-HEMOLYTIC CLYA FOR PROTEIN EXPORT AND VACCINES
Published Wednesday, May 28, 2014This technology is a specialized protein export system for efficiently producing recombinant protein from a host cell while optimizing safety for use with live vector vaccines, and is related to that described in Docket Code JG-2001-022. The UMB inventors have engineered a genetically stabilized expression plasmid incorporating the protein of...
Investigator(s): James Galen, Yuansha Chen
Categories: Research Tools, Antibodies, & Reagents
Docket: JG-2008-080
-
Myo Tak
Published Wednesday, May 28, 2014In the field of striated and smooth muscle biology, the study of the mechanical properties of muscle has relied almost exclusively on multi-cellular preparations (whole muscles or muscle strip preparations). These preparations allow for tying, clipping, or clamping of muscle tissue to mechanical apparatus via tendon or bone attachment. Single...
Investigator(s): Christopher W. Ward, Jonathon Lederer, Benjamin L. Prosser, George Rodney, Luke Michaelson
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): research tools
Docket: CW-2010-065
-
Multivalent Vaccine Against Staphylococcus Aureus
Published Wednesday, May 28, 2014There are nearly 2 million healthcare-associated infections in the U.S. per year, according to CDC-reported statistics. Many of these infections are due to colonization of implantable medical devices with drug-resistant forms of bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). The increasing incidence, morbidity and...
Investigator(s): Mark E. Shirtliff, Jan M. Harro, Jeffrey G. Leid, Rebecca Brady, Graeme O'May
Categories: Therapeutics, Vaccines
Keyword(s): vaccine, staph, Biofilm, MRSA
Docket: MS-2012-065
-
Multicellular Organotypic Tissue Engineering of the Human Intestinal Mucosa
Published Wednesday, May 28, 2014The engineering of a three-dimensional (3D) multicellular organotypic model of the human intestinal mucosa has a wide ranging potential as a tool for discovery of both health and diseases, such as interactions with pathogens, antigen trafficking, inflammatory processes, and tissue bioengineering. To more appropriately mimic an in vivo...
Investigator(s): Rosangela Mezghanni, Marcelo B. Sztein, Alessio Fasano
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): intestinal mucosa, Organotypic
Docket: RM-2011-031
-
Microcin H47 Plasmid Selection System
Published Wednesday, May 28, 2014The inventors engineered a novel stabilized plasmid selection system incorporating the gene mchI, conferring immunity against a natural antimicrobial peptide called microcin H47, which can be incorporated into the bacterial growth medium. There are no known clinical uses for microcin H47, so this approach is expected to meet vaccine regulatory...
Investigator(s): James Galen, Chee-Mun Fang
Categories: Therapeutics, Vaccines
Keyword(s): vaccine, Microcin
Docket: JG-2007-005
-
Methylated Peptides Derived from Tau Protein and Their Antibodies for Diagnosis and Therapy of Alzheimer's Disease
Published Wednesday, May 28, 2014Alzheimer's disease (AD) is a neurologically degenerative disease that is defined in part by the accumulation of aberrant tau proteins (neurofibrillary tangles) within the brain. The mechanisms which drive tau aggregation is not fully understood and existing treatments do little to delay the inevitable decline of Alzheimer's patients. UMB...
Investigator(s): Jyanyu Austin Yang, Stefani N. Thomas, Jeffrey A. Kuret, Kristen E. Funk
Categories: Diagnostics, Therapeutics
Keyword(s): Alzheimer, AD
Docket: AY-2012-036
-
Methods of treating obstructive lung diseases using bitter tastants
Published Wednesday, May 28, 2014Asthma, an obstructive lung disease and the most common chronic condition among young children, affects ~20 million Americans, causing more than 4,000 deaths each year. Researchers have discovered a method for treating asthma and related obstructive lung diseases using bitter taste agonists as bronchodilators. This invention was made possible...
Investigator(s): Stephen Liggett, Deepak Deshpande, Wayne Wang
Categories: Therapeutics
Keyword(s): lung diseases, asthma, chronic
Docket: SL-2010-062
-
Methods for Regulating Urinary Potassium
Published Wednesday, May 28, 2014Potassium is the most abundant intracellular cation. It is critically important for many physiologic processes, including maintenance of cellular membrane potential, homeostasis of cell volume, and transmission of action potentials in nerve cells. Small changes in the extracellular potassium level can have profound effects on the function of...
Investigator(s): Paul Welling, Liang Feng
Categories: Therapeutics, Small molecules, Biologics
Keyword(s): Urinary Potassium, potassium
Docket: PW-2008-072