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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Water Proton NMR for Monitoring Sedimentation Process of Multiphase Mixtures
Published Tuesday, June 27, 2023Summary The technology developed by the University of Maryland, Baltimore utilizes water proton Nuclear Magnetic Resonance (NMR) to monitor the sedimentation process in multiphase mixtures in real-time. This analytical method...
Investigator(s): Bruce Yu, Marc Taraban
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Small molecules, Chemicals, Biologics, Vaccines
Keyword(s): Sedimentation Monitoring, Multiphase Mixtures, Water Proton NMR, Pharmaceutical, Specialty Chemical, Specialty Materials
Docket: BY-2020-149
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Repurposed drugs for Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Published Monday, November 24, 2014Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are viral respiratory diseases caused by novel coronavirus strains (SARS-CoV and MERS-CoV, respectively). Categorized as a select agent in 2012, approximately 9,000 cases of SARS have been reported, with 9.5% mortality rate. To date, there have been 1,917...
Investigator(s): Mathew Frieman, Lisa Hensley, Peter Jahrling
Categories: Therapeutics, Small molecules, Chemicals, Repurpose Drug
Keyword(s): MERS, SARS, Repurposed drugs, antiviral drugs
Docket: MF-2014-090
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Control of Apoptosis by Controlling the Propensity of Ceramide Channel Formation
Published Wednesday, July 27, 2005Cell researchers believe that the efflux of proteins from mitochondria is an activation event that eventually leads to apoptosis.A number of mechanisms have been proposed for the protein permeation pathway. Candidate mechanisms include the ceramide channels. Researchers at the University of Maryland have a fairly robust model...
Categories: Chemicals, Drug Screen
Keyword(s): ion channels, apoptosis, ceramide
Docket: LS-2005-049
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Highly Efficient and Specific Oxidation of Nucleic Acids with Dinuclear Copper Complexes
Published Monday, October 7, 2002Many industrial, medicinal and biological processes rely on metal complexes to activate and control the reactive power of molecular oxygen, nature's most abundant oxidant. Selectivity of these processes is dictated by a synergy expressed between the metal and its surrounding ligands that helps to create the active complexes. Dicopper protein...
Categories: Chemicals
Keyword(s): Cancer metal compounds copper
Docket: LS-2001-087
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Metal Based Synthetic Nucleic Acid Enzymes
Published Monday, October 7, 2002Many industrial, medicinal and biological processes rely on metal complexes to activate and control the reactive power of molecular oxygen, nature's most abundant oxidant. Selectivity of these processes is dictated by a synergy expressed between the metal and its surrounding ligands that helps to create the active complexes. Dicopper protein...
Categories: Chemicals
Keyword(s): synthetic enzymes, oncology, drug adjuvants, 525
Docket: LS-2001-088