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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Muscarinic Antagonists for the Treatment of Depression
Published Monday, June 26, 2023Summary The disclosed technology describes the utilization of muscarinic antagonists for the treatment of depression. Muscarinic antagonists are a class of compounds that block muscarinic acetylcholine receptors to ameliorate...
Investigator(s): Andrew Coop, Jack Bergman, Chad Johnson, Brian Kangas, James Woods, Emily Jukiewicz, Gail Winger
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): depression, Muscarinic Antagonists, Mood Regulation
Docket: AC-2019-107
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Gallium-salophen Antimicrobial Compounds and Methods of Use Thereof
Published Wednesday, May 24, 2023Summary Pseudomonas aeruginosa (Pa), a WHO priority 1 pathogen, causes life-threatening infections. Multidrug resistant Pa has been classified by the CDC as a “serious...
Investigator(s): Fengtian Xue, Angela Wilks
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): pharmaceuticals, Clinical Medicine, Antimicrobial Compounds
Docket: FX-2020-101
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Prodrugs of anti-cancer and anti-autoimmune diseases therapeutic agents, and methods of making and use thereof
Published Wednesday, May 17, 2023Summary In summary, the invention disclosed by UMB investigators offers a promising new approach to the treatment of cancer and autoimmune diseases by introducing a series of novel prodrugs with improved safety and efficacy...
Investigator(s): Fengtian Xue, Yan Shu, Yong Li
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): Prodrug, cancer, Autoimmune, Therapeutic
Docket: FX-2019-033
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Wnt Signaling Pathway Inhibitors for Treatments of Disease
Published Wednesday, May 17, 2023Summary UMB inventors have developed compounds that inhibit the Wnt/β-catenin signaling pathway, which is implicated in various diseases, including cancer and metabolic disorders such as type 2 diabetes, obesity,...
Investigator(s): Fengtian Xue, Yan Shu
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): cancer, Metabolic Disease, diabetes
Docket: FX-2015-082
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Compounds for Treating Parasitic Infections
Published Monday, May 15, 2023Summary Researchers at the University of Maryland, Baltimore and the University of Maryland, College Park have synthesized a new class of 1,3-thiazolidine-2,4-dione derivatives that exhibit potent activity against several protozoan parasites,...
Investigator(s): Fengtian Xue, Iqbal Hamza
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): Parsitology, infection, Immunology
Docket: FX-2015-021
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Tight junction permeation enhancer peptides
Published Monday, March 23, 2015Human zonulin or pre-haptoglobin 2 (HP2) is known to reversibly regulate intestinal permeability by modulating intercellular tight junctions. Itactivates protease-activated receptor (PAR) 2, and induces signaling...
Investigator(s): Alessio Fasano, Stefanie N. Vogel
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Small molecules, Biologics, Methods of Treatment
Keyword(s): peptides, zot, zonulin, crohns asthma, glioma, celiac disease, type I diabetes, tight junction
Docket: AF-2004-004