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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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HSP90 as a Biomarker for Malignancies
Published Tuesday, May 27, 2014Heat Shock protein 90 (Hsp90)` a molecular chaperone` has shown to have a great potential as an anti-cancer target. Hsp90 antagonists (e.g. 17AAG) have emerged as promising drugs that inhibit tumor cell growth by affecting the ability of Hsp90 to fold associated molecules important in cancer growth and progression. The invention relates to...
Investigator(s): Angelika Burger, Edward Sausville
Categories: Diagnostics, Biomarker
Docket: AB-2007-015
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Fluorescence-Based Assay to Screen for Mitochondrial Protective Compounds
Published Tuesday, May 27, 2014The UMB inventors have developed an enzymatic assay which is a sensitive method for detecting mitochondrial damage. It is based on coupled enzymatic reactions that produce a detectable fluorescence signal in the presence of the reduced or oxidized form of nicotinamide adenine dinucleotide (NADH/NAD) and can detect nanomolar levels of pyridine...
Investigator(s): Tibor Kristian, Gary Fiskum
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): research tools
Docket: TK-2004-007
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Electrosurgical Element and Uterine Manipulator for Total Laparoscopic Hysterectomy
Published Tuesday, May 27, 2014During total laparoscopic hysterectomy (removal of the uterus and cervix by a minimally invasive method, TLH), separation of the uterus and the cervix from the vagina remains one of the most difficult and cumbersome steps of the procedure. This patent pending invention is a device that will simultaneously allow the surgeon to manipulate the...
Investigator(s): Vadim Morozov
Categories: Devices, Surgical devices
Keyword(s): device
Docket: VM-2009-082
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Disruption of the microtubule network as a therapeutic intervention in the muscular dystrophies
Published Tuesday, May 27, 2014Across several muscular myopathies, such as Duchenne muscular dystrophy (DMD), Becker muscular dystrophy, and dysferlinopathies, intercellular signaling cascades such as reactive oxygen signaling (ROS) and calcium (Ca2+) are enhanced and contribute to the onset and pathogenic progression of the myopathy. The discovery of the...
Investigator(s): Christopher Ward, Ramzi Khairallah
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Biologics, Engineering, Bioengineering
Keyword(s): musculoskeletal, rare disease, muscular dystrophy
Docket: CW-2012-040
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Dental Nanocomposites and Bonding Agents with Antibacterial Properties
Published Tuesday, May 27, 2014The major clinical problem associated with dental restorations is secondary cary formation and tooth restoration fractures. To address this issue, a new dental resin developed at the University of Maryland, Baltimore, was created to possess superior mechanical strength and antimicrobial properties. The formulation...
Investigator(s): Huakun Xu, Michael Weir
Categories: Dental
Keyword(s): dental, antibacterial, remineralizing
Docket: HX-2010-042 & HX-2012-066
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Defensin-like molecules as novel antimicrobial agents
Published Tuesday, May 27, 2014The ever increasing emergence of many pathogenic strains of bacteria resistant to commonly used antibiotics is a rapidly growing concern in public health and new classes of antimicrobial agents are desperately needed. One approach that has gained popularity recently is to study naturally-occurring antimicrobial peptides that have the advantage...
Investigator(s): Erik de Leeuw, Alexander MacKerell
Categories: Diagnostics, Therapeutics
Docket: ED-2012-088, ED-2010-066
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Defect-free dendrimer synthesis through proportionate branching
Published Tuesday, May 27, 2014Dendrimers are nanoparticles of synthetic monomers with applications in commercial paints, blood substitutes, nanomaterials, sensor technology. Dendrimers are also building blocks for targeted drug or gene delivery. The dendrimers open architecture forms hollow cavities within the branches that can encapsulate molecules such as drugs or...
Investigator(s): Bruce Yu, Xuyi Yue
Categories: Imaging devices, Diagnostics, Platforms, Therapeutics, Engineering, Biomaterials
Docket: BY-2012-068
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Coherence-gated Doppler: A fiber sensor for precise localization of blood flow
Published Tuesday, May 27, 2014Coherence Gated Doppler (CGD) is an optical fiber sensor technology that combines the strengths of two optical technologies, the laser Doppler flowmetry (LDF) and the optical coherence tomography (OCT). The current LDF technology remains highly sensitive but suboptimal for localization of flow signals while the OCT and its Doppler variant, DOCT...
Investigator(s): Cha-Min Tang, Chia-Pin Liang, Yu Chen, Ashraf Fouad, Joseph Schmitt
Categories: Devices, Surgical devices
Docket: CT-2013-008
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Clostridium difficile Type IV Pilin As New Target for Vaccine, Therapeutics and Diagnostics
Published Tuesday, May 27, 2014Type IV pilin proteins are extracellular and easily accessible to the host immune system, as well as being important for initial colonization and biofilm formation. Thus, these proteins present excellent targets for vaccines to prevent pathogen colonization. Neutralizing antibodies directed against pili could lead to...
Investigator(s): Michael Donnenberg
Categories: Diagnostics, Therapeutics, Vaccines
Keyword(s): vaccine
Docket: MD-2008-081
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Case Mounting Stabilizers
Published Tuesday, May 27, 2014This device is used for relating casts, molds of the patient's mouth, which are used in the the construction of dentures, partial dentures, bridges, crowns, and implant restorations. No similar product is available, and dentists rely on improvised methods that are not always reliable.
Investigator(s): Sharon Siegel
Categories: Devices, Dental
Keyword(s): dental
Docket: SS-98-042