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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Encryption Scheme Utilizing the Pattern of Biometric Scanners
Published Sunday, July 9, 2017As mobile devices are increasingly used to send sensitive information through a network, it has become imperative to provide those devices with effective but compact encryption schemes to secure the data. Biometric information has been used to secure the operation of the mobile devices themselves, but such systems do not prevent the interception...
Keyword(s): 525
Docket: IS-2016-019
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A Data Visualization Tool to Explore Multidimensional Clinical Datasets
Published Monday, June 19, 2017WinnowTM is an innovative tool to efficiently sift through arrays of longitudinal data, identify patterns, generate hypotheses, and subject these hypotheses to rigorous statistical analysis. It has an intuitive, interactive and insightful platform- valuable to all...
Investigator(s): Lisa Shulman, MD ; Amitabh Varshney, PhD
Categories: Software + Algorithm, Healthcare, Information Technology, Genomics/Proteomics/Database
Keyword(s): Software; Algorithm; Healthcare; Information Technology; Data Analytics
Docket: LS-2017-024
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Rational Targeting of Protein Translation in Cancer Cells
Published Wednesday, June 14, 2017Deregulation of protein translation is associated with a growing number of human diseases, including tumorigenesis. The mammalian mTOR pathway has garnered considerable interest as a major target for new anti-cancer therapies due to its key role in regulating cell growth. However, clinical applications have been limited due to the role of this...
Investigator(s): France Carrier
Categories: Therapeutics
Keyword(s): oncology, mROR
Docket: FC-2015-047
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New Compounds to Treat Metastatic and Triple Negative Breast Cancer
Published Wednesday, May 31, 2017Despite multi-modal treatment, approximately 40% of all women with breast cancer will suffer a recurrence. While the 10-year overall survival rate for women without recurrence is 84%, this drops to 49%-72% for women with a locoregional recurrence or a second primary malignancy. Luminal breast cancer has the highest rates of relapse, often...
Investigator(s): Antonino Passaniti, Alexander MacKerell
Categories: Therapeutics, Small molecules
Keyword(s): breast cancer, oncolytic, small molecule, CADD
Docket: AP-2015-080
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Gateway Languages Database
Published Monday, May 29, 2017BackgroundThere are some situations when fast language acquisition skills are needed, such as when a company has a newfound economic interest, a humanitarian organization identifies a crisis, or a defense contractor wishes to fill a critical capabilities gap. Even when time is not an issue, there is a need to be able to identify the likely...
Keyword(s): language, learning, language database, country database, language acquisition skills
Docket: IS-2016-177
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Irreversible Inhibitors of Type II Transglutaminase
Published Thursday, May 25, 2017Cancer stem cells (CSC) comprise a subpopulation of tumor cells that are slow-cycling, express stem cell markers, display enhanced migratory potential, undergo epithelial-mesenchymal transition (EMT), and form rapidly growing and highly vascularized and aggressive tumors. CSC often survive conventional cancer therapy and proceed to form rapidly...
Investigator(s): Abdullah Akbar, Gail Johnson, Jeffrey Keillor, Matthew Fisher, Richard Eckert
Categories: Small molecules
Keyword(s): Therapeutic, cancer, Cancer Stem Cells
Docket: RE-2016-066
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Dichloroacetate and Arsenic Trioxide as an Acute Myeloid Leukemia Combination Therapy
Published Tuesday, May 16, 2017UMB research has been directed at a synergistic combination drug formulation of dichloroacetate and arsenic trioxide to treat AML. AML cells, compared to normal cells, have an increased susceptibility to the disruption of balance of oxidative forces. Selective targeting of the oxidative state, which is a tightly balanced...
Investigator(s): Ashkan Emadi, MD; Rena Lapidus, PhD
Categories: Repurpose Drug, Methods of Treatment
Keyword(s): AML; Acute Myeloid Leukemia; Combination Therapy; Arsenic Trioxide
Docket: AE-2013-045
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eLVOTD: Estimation of the Left Ventricular Outflow Tract Diameter
Published Monday, May 15, 2017The left ventricular outflow tract diameter (LVOTD) is one of two measurements needed to calculate cardiac stroke volume and cardiac output (CO). CO is an important measure of heart function and can help determine the need for inotropic support of the heart. In combination with mean arterial blood pressure, CO can also be used to determine the...
Investigator(s): Sarah Murthi
Categories: Diagnostics, Imaging, Software + Algorithm
Keyword(s): Acute care
Docket: SM-2017-060
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Balanced Reach Control Systems Model
Published Tuesday, May 2, 2017Bipedal standing balance is inherently unstable and must be actively controlled to prevent falling. This involves a complex interaction of the sensorimotor system and multi-segment musculoskeletal system. Fall risk increases with deterioration of sensorimotor and musculoskeletal elements responsible for balance due to age, neurological...
Investigator(s): Joseph E. Barton
Categories: Devices, Imaging devices, Software + Algorithm, Methods of Treatment
Keyword(s): Rehabilitation, balance, reaching, Aging Population
Docket: JB-2016-005, JB-2016-004
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Inhibition of Galectin 3 Binding to the Airway Epithelial Surface to Treat or Prevent Septic Shock Resulting from Influenza and Subsequent Pneumococcal Pneumonia Infection
Published Tuesday, May 2, 2017The main cause of death during influenza pandemics is Streptococcus pneumoniae co-infection, which results in hyperinflammatory response leading to sepsis. While the exact mechanism behind this complication is not understood, influenza infection predisposes patients to pneumococcal pneumonia that often progresses to uncontrolled...
Investigator(s): Gerardo R. Vasta, Lai-Xi Wang
Categories: Therapeutics
Keyword(s): sepsis, influenza, antiinflammatory
Docket: GV-2015-133