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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Compositions and Methods for Determining the Likelihood of Appendicitis
Published Tuesday, August 25, 2015Appendicitis is a condition that is easily treated through the surgical removal of the appendix. However, delays in diagnosis beyond 24-36 hours from the start of symptoms can lead to an increased risk of mortality, morbidity, and costs due to complications. Diagnosis is complicated by the heterogeneous clinical presentation of...
Investigator(s): Anthony Sandler, Claire M. Fraser, Emmanuel Mongodin, Hope Jackson, Katherine Davenport, Steven L. Zeichner
Categories: Diagnostics, Biomarker, Genomics/Proteomics/Database
Keyword(s): Appendicitis, Appendix, Microbiota, bacteria
Docket: CF-2014-074
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Portable Multi-Parameter Cancer Diagnostic Device
Published Sunday, May 17, 2015Background: Each year in USA alone, more than 200,000 breast cancer cases are diagnosed. The transformation from benign to cancerous state changes the morphological signatures in the tumor environment. Mechanical and electrical phenotyping has been demonstrated as a promising technique to study the progression of the breast cancer. Thus, a...
Categories: Diagnostics, Platforms, Devices
Keyword(s): breast cancer, Cancer Diagnosis
Docket: PS-2015-017
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Use of Omentin for Treatment and Prediction of Disease
Published Wednesday, January 28, 2015Obesity, especially accumulation of abdominal fat, is a risk factor for the development of type 2 diabetes and cardiovascular disease. More than one-third of US adults are considered to be obese. Omentin is an adipokine expressed and secreted from abdominal but not subcutaneous...
Investigator(s): Da-Wei Gong, Alan Shuldiner, John McLenithan, Rongze Yang
Categories: Research Tools, Antibodies, & Reagents, Diagnostics, Therapeutics, Biologics, Biomaterials
Keyword(s): omentin, diabetes, obesity, cardiovascular
Docket: DG-2002-013, DG-2007-087, DG-2009-093
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Microdevice for the Detection of Sequence Differences in Biological Samples
Published Tuesday, November 4, 2014BackgroundWith the advancements in biomedical research, accurate sequencing of biological samples is becoming of greater importance. The completion of the Human Genome Project has highlighted the potential of single nucleotide polymorphisms (SNPs) in DNA while the increase in protein-based therapies has increased interest in the...
Categories: Diagnostics, Devices, Research Tools, Antibodies, & Reagents
Keyword(s): Gene sequencing, protein sequencing, lab-on-chip
Docket: LS-2014-076
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Targeted Delivery of Imaging Probes for In Vivo Cellular Imaging
Published Thursday, May 29, 2014Electron paramagnetic resonance (EPR) imaging is a technique for studying molecules that have one or more unpaired electrons, such as organic and inorganic free radicals or complexes with a transition metal ion. EPR may be thought of as analogous to MRI, except that it measures the excitation of electron spins instead of atomic nuclei. Given...
Investigator(s): Joseph Kao, Gerald Rosen, Scott Burks
Categories: Research Tools, Antibodies, & Reagents, Diagnostics
Keyword(s): imaging
Docket: JK-2010-098
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Novel Alternatively Spliced Human Androgen Receptor Variants as Biomarkers for Prostate Cancer
Published Wednesday, May 28, 2014Prostate cancer is the second leading cause of cancer death among men in western countries. Patients with advanced prostate cancer initially benefit from androgen ablation therapy which leads to temporary remission of the tumor due to apoptosis of androgen-sensitive tumor cells. However, the recurrence of androgen-independent tumors is...
Investigator(s): Yun Qiu, Zhiyong Guo, Xi Yang
Categories: Diagnostics
Keyword(s): prostate cancer, biomarker, cancer
Docket: YQ-2008-056
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Methylated Peptides Derived from Tau Protein and Their Antibodies for Diagnosis and Therapy of Alzheimer's Disease
Published Wednesday, May 28, 2014Alzheimer's disease (AD) is a neurologically degenerative disease that is defined in part by the accumulation of aberrant tau proteins (neurofibrillary tangles) within the brain. The mechanisms which drive tau aggregation is not fully understood and existing treatments do little to delay the inevitable decline of Alzheimer's patients. UMB...
Investigator(s): Jyanyu Austin Yang, Stefani N. Thomas, Jeffrey A. Kuret, Kristen E. Funk
Categories: Diagnostics, Therapeutics
Keyword(s): Alzheimer, AD
Docket: AY-2012-036
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Method for the identification of microbial community signature as diagnostic markers, including specific applications for the diagnosis of Crohn's disease and ulcerative colitis.
Published Wednesday, May 28, 2014The two most common forms of inflammatory bowel disease (IBD), are Crohn's and ulcerative colitis, disease states in which the body elicits an immune response within the gastrointestinal tract causing chronic pain, inflammation, and intestinal distress. Though distinctly different, the two diseases often share common symptoms making a...
Investigator(s): W. Florian Fricke, James White
Categories: Diagnostics
Keyword(s): Crohn's disease, ulcerative colitis
Docket: WF-2012-079
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Method and Assay for Early Diagnosis of Prostate Cancer
Published Wednesday, May 28, 2014For well over 20 years, digital rectal examination (DRE) combined with the measurement of prostate specific antigens (PSA) have remained the most recommended screening tests for the detection of prostate cancer for men over 40. However, both exams remain highly unreliable due to the high prevalence of false positive and negative results. To...
Investigator(s): Hafiz Ahmed, Gerardo Vasta
Categories: Diagnostics
Keyword(s): prostate cancer, cancer
Docket: HA-2010-082
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Inhibitors of S100 Proteins for the Treatment of Cancer and Other Diseases Involving Uncontrolled Cell Growth via an S100-Dependent Pathway
Published Wednesday, May 28, 2014Small molecules have been identified, using rational drug design, that bind to a site on S100 proteins, rendering S100 incapable of inactivating p53 tumor suppressor protein. Inhibitors of S100 thus restore tumor suppressor activity of the p53 protein by inhibiting the S100-p53 interaction. Inhibitors are specific to different members of the...
Investigator(s): David Weber, Joseph Markowitz, France Carrier
Categories: Diagnostics, Therapeutics, Small molecules
Keyword(s): tumor, cancer, S100 proteins, research tools
Docket: DW-2002-041