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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Noninvasive Aortic Blood Pressure Measurement for Prediction of Cardiovascular Disease Risk
Published Tuesday, May 27, 2014BackgroundCardiovascular disease (CVD) is the number one cause of death in the US and the world, with an estimated 32.8% of deaths in the US having cardiovascular (CV) related factors. Ailments such as hypertension, atherosclerosis, myocardial infarction (heart attacks), and heart failure are all related to CVD. There are many ways of...
Categories: Healthcare, Diagnostics
Keyword(s): Cadiovascular disease, clinical, blood pressure, healthcare, heart disease, medical device
Docket: IS-2013-088
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High affinity recombinant sea lamprey antibodies selected by a yeast surface display platform.
Published Tuesday, May 27, 2014Immunoglobulin-based antibody therapeutics are enjoying unprecedented success. Hundreds are in clinical trials, with revenues from the top five (Rituxan, Remicade, Herceptin, Humira, and Avastin) increasing from $6.4 billion in 2004 to $11.7 billion in 2006 (Dimitrov & Marks, 2009). Thousands more are available for biological detection...
Investigator(s): Zeev Pancer, Roy Mariuzza, Satoshi Tasumi, Carlos Velikousky
Categories: Diagnostics, Platforms
Docket: ZP-2010-085
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HSP90 as a Biomarker for Malignancies
Published Tuesday, May 27, 2014Heat Shock protein 90 (Hsp90)` a molecular chaperone` has shown to have a great potential as an anti-cancer target. Hsp90 antagonists (e.g. 17AAG) have emerged as promising drugs that inhibit tumor cell growth by affecting the ability of Hsp90 to fold associated molecules important in cancer growth and progression. The invention relates to...
Investigator(s): Angelika Burger, Edward Sausville
Categories: Diagnostics, Biomarker
Docket: AB-2007-015
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Defensin-like molecules as novel antimicrobial agents
Published Tuesday, May 27, 2014The ever increasing emergence of many pathogenic strains of bacteria resistant to commonly used antibiotics is a rapidly growing concern in public health and new classes of antimicrobial agents are desperately needed. One approach that has gained popularity recently is to study naturally-occurring antimicrobial peptides that have the advantage...
Investigator(s): Erik de Leeuw, Alexander MacKerell
Categories: Diagnostics, Therapeutics
Docket: ED-2012-088, ED-2010-066
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Defect-free dendrimer synthesis through proportionate branching
Published Tuesday, May 27, 2014Dendrimers are nanoparticles of synthetic monomers with applications in commercial paints, blood substitutes, nanomaterials, sensor technology. Dendrimers are also building blocks for targeted drug or gene delivery. The dendrimers open architecture forms hollow cavities within the branches that can encapsulate molecules such as drugs or...
Investigator(s): Bruce Yu, Xuyi Yue
Categories: Imaging devices, Diagnostics, Platforms, Therapeutics, Engineering, Biomaterials
Docket: BY-2012-068
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Clostridium difficile Type IV Pilin As New Target for Vaccine, Therapeutics and Diagnostics
Published Tuesday, May 27, 2014Type IV pilin proteins are extracellular and easily accessible to the host immune system, as well as being important for initial colonization and biofilm formation. Thus, these proteins present excellent targets for vaccines to prevent pathogen colonization. Neutralizing antibodies directed against pili could lead to...
Investigator(s): Michael Donnenberg
Categories: Diagnostics, Therapeutics, Vaccines
Keyword(s): vaccine
Docket: MD-2008-081
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Novel Genetic Mutations Associated with Lactose Persistence in African and Middle Eastern Populations.
Published Monday, July 27, 2009In humans, lactose intolerance is caused by the inability to metabolize lactose, the main carbohydrate present in milk. In adults the ability to digest lactose declines rapidly after weaning because of decreasing levels of the enzyme lactase phlorozin hydrolase (LPH). LPH is predominantly expressed in the small intestine, where it hydrolyzes...
Categories: Diagnostics
Keyword(s): genetic mutation, dietary, health
Docket: LS-2006-101
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Borrelia Burgdorferi Genetic Markers for Lyme Disease Diagnostics
Published Thursday, April 16, 2009BackgroundDiagnosing Lyme disease is notoriously difficult for physicians and veterinarians. Available tests have improved significantly over the last few decades but still leave much room for increased accuracy of results. As the genetic design of Lyme disease pathogen Borrelia burgdorferi is more fully understood, diagnostic kits may be...
Categories: Diagnostics, Biomarker
Keyword(s): Lyme Disease, Borrelia burgdorferi, B. burgdorferi, vaccine, diagnostic markers
Docket: LS-2009-015
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