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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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TWEAK as a Therapeutic Target for Treating Stroke and Other Central Nervous System Diseases
Published Thursday, May 29, 2014Research shows that a TNF-related cytokine known as TWEAK is a causative agent for some of the effects seen in ischemic stroke. When TWEAK binds to a receptor called Fn14 on the surface of neuronal, glial and endothelial cells in the brain, it causes three main effects which result in brain tissue damage: (1) release of pro-inflammatory factors...
Investigator(s): Jeffrey Winkles, Manuel Yepes
Categories: Therapeutics
Keyword(s): stroke, neurovascular
Docket: JW-2005-037
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Techniques for Implementing a Virtual Patient
Published Thursday, May 29, 2014Medical care delivery is a major industry in the United States. An important component of medical care delivery is a cadre of trained medical care professionals who can diagnose patient conditions and prescribe treatment protocols using cognitive skills. The fewer errors made by this cadre, the better the overall quality of medical care is...
Investigator(s): Bruce Jarrell, Sergei Nirenburg, Joan Marjorie McShane, Stephen Beale
Categories: Software + Algorithm, Education/Training/Multimedia
Keyword(s): training, virtual, patient
Docket: BJ-2006-061
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Surgical Abdominal Wall Model
Published Thursday, May 29, 2014The Surgical Abdominal Wall (SAW) model is a physical/mechanical model developed by researchers at UMB to simulate laparoscopic ventral hernia repair (LVHR) and other abdominal wall surgical procedures. Materials were carefully chosen to simulate skin, tissue, organs, and adhesions associated with abdominal wall morphology and pathology....
Investigator(s): Adrian Park, Ivan George, F. Jacob Seagull
Categories: Devices
Docket: AP-2008-024
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Subwavelength Resolution Optical Microscopy
Published Thursday, May 29, 2014Optical microscopy, both transmission and fluorescence, has limited spatial resolution due to well-known limits of diffraction. In addition, few methods are available to increase spatial resolution. The invention describes a novel and a simple method of increasing optical resolution. The present technology can be specifically used to image...
Investigator(s): Joseph Lakowicz, Mustafa Chowdury, Chandran Subanagayam
Categories: Devices, Imaging devices
Docket: JL-2007-088
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Strategy for a Broad-Spectrum Vaccine Against Non-Typhoidal Salmonella
Published Thursday, May 29, 2014On screening sub-Saharan African residents over the last decade for signs of invasive bacterial infection, a high incidence of non-typhoidal Salmonella (NTS) infections was discovered, and these cases were associated with antibiotic resistance and a high mortality of 20-30%. The invasive strains of NTS are dominated by Salmonella Typhimurium...
Investigator(s): Myron Levine, Sharon Tennant, Raphael Simon, James Galen
Categories: Therapeutics, Vaccines
Keyword(s): salmonella, vaccine
Docket: ML-2009-033
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Straight Expandable Polypectomy Forceps
Published Thursday, May 29, 2014Endoscopic biopsy forceps are routinely used for the resectioning of small, sessile, sub-centimeter polyps of the gastrointestinal tract. Originally invented to biopsy and sample mucosa, these forceps remain inadequate for the resectioning of entire polyps and often require multiple passes for complete removal. In order to resolve this issue,...
Investigator(s): Florence M. Aslinia, M.D., MS Eric Goldberg
Categories: Devices, Surgical devices
Keyword(s): device
Docket: FA-2012-062
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Small Molecule Inhibitors of BCL6
Published Thursday, May 29, 2014BCL6 is a transcription factor essential for germinal center B-cell development. The BTB domain (also known as the POZ domain) is a common protein-protein interaction motif that is found in over 180 human proteins including BCL6 and has been implicated in many biological processes including central nervous development, oocyte maturation, eye...
Investigator(s): Alexander Donald MacKerell, Jr., Ari M. Melnic, k Gilbert G. Prive
Categories: Therapeutics, Small molecules
Keyword(s): small molecules
Docket: AM-2007-053
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Small Molecule Inhibitors Of Kynurenine 3-Monooxygenase
Published Thursday, May 29, 2014Kynurenic acid has neuroprotective activities in vivo while the metabolic byproduct of kynurenic acid, quinolinic acid, is neurotoxic. Kynurenine 3-monooxygenase catalyzes the conversion of kynurenine into 3-hydroxykynurenine, a precusor of neurotoxic quinolinic acid. In light the properties of kynurenic acid and quinolinic acid,...
Investigator(s): Robert Schwarcz, Paulo Guidetti
Categories: Therapeutics, Small molecules
Docket: RS-2007-032
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Salmonella Based Oral Vaccines for Anthrax
Published Thursday, May 29, 2014Recent heightened awareness of the possibility of bioterrorism has raised concerns about the use of Bacillus anthracis or related strains as bio-weapons. Anthrax is an infection caused by the spore-forming bacterium B. anthracis, which can enter the body and cause infection by means of inhalation, ingestion, or subcutaneous exposure. There is a...
Investigator(s): Leslie Baillie
Categories: Vaccine
Keyword(s): Anthrax, vaccine, salmonella
Docket: LB-2010-092
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SILCS: Site Identification by Ligand Competitive Saturation. Method for binding site identification by molecular dynamics simulation
Published Thursday, May 29, 2014The present invention is directed to a method of computational chemistry for identifying binding sites by molecular dynamics simulations using ligand competitive saturation. Fragment-based drug discovery relies on a simple premise: identify small molecule fragments that bind to a target region of a large molecule and then evolve or link the...
Investigator(s): Alex MacKerell Jr., Olgun Guvench
Categories: Research Tools, Antibodies, & Reagents, Software + Algorithm
Keyword(s): simulation, drug design
Docket: AM-2009-054