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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Microcin H47 Plasmid Selection System
Published Wednesday, May 28, 2014The inventors engineered a novel stabilized plasmid selection system incorporating the gene mchI, conferring immunity against a natural antimicrobial peptide called microcin H47, which can be incorporated into the bacterial growth medium. There are no known clinical uses for microcin H47, so this approach is expected to meet vaccine regulatory...
Investigator(s): James Galen, Chee-Mun Fang
Categories: Therapeutics, Vaccines
Keyword(s): vaccine, Microcin
Docket: JG-2007-005
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Clostridium difficile Type IV Pilin As New Target for Vaccine, Therapeutics and Diagnostics
Published Tuesday, May 27, 2014Type IV pilin proteins are extracellular and easily accessible to the host immune system, as well as being important for initial colonization and biofilm formation. Thus, these proteins present excellent targets for vaccines to prevent pathogen colonization. Neutralizing antibodies directed against pili could lead to...
Investigator(s): Michael Donnenberg
Categories: Diagnostics, Therapeutics, Vaccines
Keyword(s): vaccine
Docket: MD-2008-081
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Attenuated Strains of SalmonellaTyphi as Mucosal Live Typhoid Vaccines and Expression Vectors
Published Tuesday, May 27, 2014Salmonella enterica serovar Typhi is the cause of typhoid fever, which remains an important public health problem in many parts of the world. Attenuated strains of S. Typhi were engineered by researchers at UMB's Center for Vaccine Development, and selected strains have proven safe and immunogenic in Phase 1 and Phase 2 human trials. The same...
Investigator(s): Fernando Noriega, Myron Levine, Marcelo Sztein
Categories: Therapeutics, Vaccines
Keyword(s): vaccine
Docket: FN-98-001