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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Anti-shark IgNar mouse monoclonal (GA8) antibody
Published Tuesday, September 22, 2015The cartilaginous fish (sharks, skates, and rays) have a human-type adaptive immune system as well as immunoglobulins (Igs). In addition to the heavy-light chain heterodimeric isotypes (IgM and IgW), sharks also produce a novel isotype called IgNAR. IgNAR is a heavy chain homodimer that does not associate with light chains....
Investigator(s): Martin Flajnik
Categories: Research Tools, Antibodies, & Reagents
Docket: MF-2009-077
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A stable Receptor-Associated Protein (RAP) protein
Published Tuesday, September 22, 2015A novel Stable Receptor-Associated Protein (RAP), an antagonist of lipoprotein receptor-related protein 1 (LRP1). Dr. Strickland at UMB has developed a stable RAP D3 domain (with 6 mutations) that is resistant to both pH- and heat-induced denaturation. The molecule binds to lipoprotein receptor-related protein 1 (LRP1) with high affinity...
Investigator(s): Dudley Strickland
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): RAP Protein stable
Docket: DS-2015-111
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Anti-GRIM-19 antibody
Published Thursday, May 7, 2015Anti-GRIM-19 (1A8) is a mouse monoclonal antibody for detecting Retinoic-Interferon-induced Mortality 19 (GRIM-19) protein. This antibody was raised against the recombinant human GRIM-19 and can recognize both human and mouse GRIM-19. GRIM-19 is widely expressed in humans, with highest expression in heart, skeletal muscle, liver, kidney...
Investigator(s): Dhan V. Kalvakolanu
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): grim, antibody, tumor suppressor, COPD, carcinoma
Docket: DK-2003-050
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Tight junction permeation enhancer peptides
Published Monday, March 23, 2015Human zonulin or pre-haptoglobin 2 (HP2) is known to reversibly regulate intestinal permeability by modulating intercellular tight junctions. Itactivates protease-activated receptor (PAR) 2, and induces signaling...
Investigator(s): Alessio Fasano, Stefanie N. Vogel
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Small molecules, Biologics, Methods of Treatment
Keyword(s): peptides, zot, zonulin, crohns asthma, glioma, celiac disease, type I diabetes, tight junction
Docket: AF-2004-004
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Use of Omentin for Treatment and Prediction of Disease
Published Wednesday, January 28, 2015Obesity, especially accumulation of abdominal fat, is a risk factor for the development of type 2 diabetes and cardiovascular disease. More than one-third of US adults are considered to be obese. Omentin is an adipokine expressed and secreted from abdominal but not subcutaneous...
Investigator(s): Da-Wei Gong, Alan Shuldiner, John McLenithan, Rongze Yang
Categories: Research Tools, Antibodies, & Reagents, Diagnostics, Therapeutics, Biologics, Biomaterials
Keyword(s): omentin, diabetes, obesity, cardiovascular
Docket: DG-2002-013, DG-2007-087, DG-2009-093
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Thermostabilization of DNA Polymerase with Novel Chaperones
Published Thursday, May 29, 2014Dr. Frank Robb has considerable expertise in the study of microbes found in extreme environments and their mechanisms of survival. These astonishing organisms have protein chaperone systems that enable them to survive and even thrive in extreme heat and harsh chemical conditions. An important application for these chaperones is to enhance...
Investigator(s): Frank Robb, Pongpan Laksanalamai
Categories: Research Tools, Antibodies, & Reagents, Engineering, Chemical
Docket: FR-2010-087
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Targeted Delivery of Imaging Probes for In Vivo Cellular Imaging
Published Thursday, May 29, 2014Electron paramagnetic resonance (EPR) imaging is a technique for studying molecules that have one or more unpaired electrons, such as organic and inorganic free radicals or complexes with a transition metal ion. EPR may be thought of as analogous to MRI, except that it measures the excitation of electron spins instead of atomic nuclei. Given...
Investigator(s): Joseph Kao, Gerald Rosen, Scott Burks
Categories: Research Tools, Antibodies, & Reagents, Diagnostics
Keyword(s): imaging
Docket: JK-2010-098
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Targeted Conditional Expression of Proteins to Cell-Type
Published Thursday, May 29, 2014Mitochondrial dysfunction has been implicated in the pathogenesis of a plethora of neurodegenerative disorders (e.g., stroke, Parkinson's, amyotrophic lateral sclerosis, Huntington's, Alzheimer's, etc.). However, effective models useful for elucidating mechanisms and therapies associated with neuronal mitochondrial dysfunction are lacking. This...
Investigator(s): Krish Chandrasekaran, Tibor Kristian
Categories: Research Tools, Antibodies, & Reagents
Docket: KC-2006-026
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SILCS: Site Identification by Ligand Competitive Saturation. Method for binding site identification by molecular dynamics simulation
Published Thursday, May 29, 2014The present invention is directed to a method of computational chemistry for identifying binding sites by molecular dynamics simulations using ligand competitive saturation. Fragment-based drug discovery relies on a simple premise: identify small molecule fragments that bind to a target region of a large molecule and then evolve or link the...
Investigator(s): Alex MacKerell Jr., Olgun Guvench
Categories: Research Tools, Antibodies, & Reagents, Software + Algorithm
Keyword(s): simulation, drug design
Docket: AM-2009-054
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Pluripotent Stem Cell Production Method
Published Wednesday, May 28, 2014One of the major hurdles in stem cell research is that techniques for purification and propagation can be tedious and result in low yields. Standard methods require feeder cells, matrix, and serum, which are expensive and can introduce contaminants. UMB researchers, however, have developed an alternative method to consistently and reliably...
Investigator(s): G. David Trisler, Bernard M. Pessac, Christopher T. Bever Jr., James E. Goolsby
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Stem Cells
Keyword(s): stem cell
Docket: GT-2004-009