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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Noninvasive Quantitation of Full Versus Empty Capsids Using Water Proton NMR
Published Wednesday, May 17, 2023Summary This invention proposes a method for using NMR relaxation rates to determine whether capsid preparations contain empty or full viral capsids and to quantify the capsid content of the preparation....
Investigator(s): Bruce Yu, Marc Taraban
Categories: Devices, Diagnostics, Therapeutics, Small molecules, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze Thaw
Docket: BY-2020-059
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Detection of Pharmaceutical Product Freezing History using Water Proton NMR
Published Wednesday, May 17, 2023Summary Researchers at UMB have created an innovative method that employs water proton nuclear magnetic resonance (NMR) spectroscopy to detect the freezing history of pharmaceutical products. This technology compares the...
Investigator(s): Bruce Yu, Marc Traban, Katharine Briggs
Categories: Devices, Therapeutics, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze-Thaw
Docket: BY-2019-081
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In situ determination of alum filling evenness and sedimentation in pharmaceutical products using water NMR
Published Wednesday, May 17, 2023Summary The invention describes a fast and non-destructive technique to determine the evenness of alum particle filling levels and/or...
Investigator(s): Bruce Yu, Christopher Fox, Marc Taraban
Categories: Diagnostics, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing
Docket: BY-2019-021
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Prodrugs of anti-cancer and anti-autoimmune diseases therapeutic agents, and methods of making and use thereof
Published Wednesday, May 17, 2023Summary In summary, the invention disclosed by UMB investigators offers a promising new approach to the treatment of cancer and autoimmune diseases by introducing a series of novel prodrugs with improved safety and efficacy...
Investigator(s): Fengtian Xue, Yan Shu, Yong Li
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): Prodrug, cancer, Autoimmune, Therapeutic
Docket: FX-2019-033
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Combination Assessment of Volume Status (CAVS)
Published Wednesday, May 17, 2023Early and aggressive fluid resuscitation in shock is associated with improved patient outcome and mortality. However, there is a clear correlation between cumulative fluid balance and mortality. There is, therefore, a benefit to adopting a systematic approach to fluid resuscitation to determine which patients would benefit from a fluid bolus...
Investigator(s): Sarah Murthi
Categories: Diagnostics, Software + Algorithm
Keyword(s): CAVS, shock, ultrasound, POCUS
Docket: SM-2016-067
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Solvent nuclear magnetic resonance for noninvasive inspection of particle-containing products
Published Wednesday, May 17, 2023Summary This patented technology uses solvent nuclear magnetic resonance (NMR) as a noninvasive method for quality control testing of particle products in both pharmaceuticals and non-pharmaceuticals. This technique is rapid,...
Investigator(s): Bruce Yu, Marc Taraban
Categories: Diagnostics, Industrial Processing, Other
Keyword(s): NMR, Pharmaceutical, food, nanoparticles, Quality Control, Counterfeit Detection
Docket: BY-2017-009
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Wnt Signaling Pathway Inhibitors for Treatments of Disease
Published Wednesday, May 17, 2023Summary UMB inventors have developed compounds that inhibit the Wnt/β-catenin signaling pathway, which is implicated in various diseases, including cancer and metabolic disorders such as type 2 diabetes, obesity,...
Investigator(s): Fengtian Xue, Yan Shu
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): cancer, Metabolic Disease, diabetes
Docket: FX-2015-082
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Device and Method for Transseptal Puncture
Published Wednesday, May 17, 2023Atrial fibrillation (AF) and mitral valve (MV) disease are two of the most common cardiac conditions. AF affects between 2.7 and 6.1 million American adults each year. MV disease is the most common heart valve lesion, impacting 1.7% of U.S. adults (9.3% of people ≥ 75 years old). Both AF and...
Investigator(s): James Gammie, Rachel Quinn, Chetan Pasrija
Categories: Devices, Surgical devices, Methods of Treatment
Keyword(s): Atrial fibrilation, Mitral valve, catheter, Transseptal puncture
Docket: JG-2017-030
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Compounds for Treating Parasitic Infections
Published Monday, May 15, 2023Summary Researchers at the University of Maryland, Baltimore and the University of Maryland, College Park have synthesized a new class of 1,3-thiazolidine-2,4-dione derivatives that exhibit potent activity against several protozoan parasites,...
Investigator(s): Fengtian Xue, Iqbal Hamza
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): Parsitology, infection, Immunology
Docket: FX-2015-021
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KCNMA1-N999S Transgenic Mouse Line
Published Monday, May 1, 2023KCNMA1-N999S knock-in mice express a gain-of-function (GOF) asparagine to serine substitution at position 999 of the potassium large conductance calcium-activated channel, subfamily M, alpha member 1 gene. Mice exhibit increased channel activity, decreased seizure thresholds, and become immobile following (stress) restraint. These mice may be...
Investigator(s): Andrea Meredith
Docket: AM-2021-018