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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Use of EM 1412 as a vaginal microbicide for HIV, HPV and HSV transmission
Published Friday, November 7, 2014Cervical dysplasia is the existence of abnormal cells in the cervix, which may indicate a pre-cancerous condition. In the United States, 250,000 to 1 million women are diagnosed with cervical dysplasia annually in which 30% to 50% possibly progressing to invasive cancer without treatment. In order to address this issue...
Investigator(s): Niharika Khanna, Neil Frazier, Ru Chi Huang
Categories: Therapeutics, Repurpose Drug, Natural Compounds
Docket: NK-2004-057
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Extending and Maintaining Micropore Viability of Microneedle Treated Skin with Cholesterol Synthesis Inhibitors
Published Wednesday, October 1, 2014Transdermal drug delivery is an attractive alternative to oral delivery (which may reduce drug efficacy by first pass metabolism) and hyperdermic injections (which are commonly associated with pain and systemic side effects). A limited spectrum of drugs are able to passively cross the stratum corneum (SC, the outermost layer of...
Investigator(s): Audra L. Stinchcomb, Priyanka Ghosh
Keyword(s): Therapeutic
Docket: AS-2013-103
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An Automated Medical Student Performance Evaluation Software
Published Friday, September 26, 2014In the United States and Canada, a Medical Student Performance Evaluation (MSPE) is required as part of a medical student’s residency application. The MSPE includes specific information from the student’s academic record including both didactic and clinical courses. The Automated Student Affairs Processes (ASAP) is a user-friendly, platform...
Investigator(s): Kevin Brown, Priyanka Koneru, Sara Menso
Categories: Platforms, Software + Algorithm, Information Technology, Education/Training/Multimedia
Keyword(s): MSPE, software, medical school, administrative office, medical admissions
Docket: KB-2014-002
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Zona Incerta Stimulation for Chronic Pain Relief
Published Thursday, May 29, 2014Central pain syndrome (CPS) is a debilitating condition affecting with lesions or dysfunction in the central nervous system. CPS is a neurological disorder resulting from damage to or dysfunction of the pain-conducting pathways of the central nervous system. The patented invention describes a novel method for treating CPS regions of the...
Investigator(s): Asef Keller, Raimi Quiton, Peter Murray, Radi Masri, Jessica Lucas
Categories: Devices, Methods of Treatment
Keyword(s): chronic, pain, device, neurostimulation
Docket: AK-2009-044
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ZAP-70 As Biomarker and Immune System Modulator
Published Thursday, May 29, 2014The body's immune system is characterized by its ability to rapidly respond to foreign antigens (part of a bacterial or cancer cell, for example) that were previously encountered. This rapid response is mediated by memory T lymphocytes. When these cells are activated, they produce effector cytokines, such as TNF-alpha and IFN-gamma, which...
Investigator(s): Donna Farber, Francesca Okoye, Meena Chandok
Keyword(s): immune system, T cell, biomarker
Docket: DF-2008-006
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Vaccines Against ETEC with Isolation and Characterization of the csa Operon (ETEC-CS4 Pili)
Published Thursday, May 29, 2014Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea in infants and young children in developing countries, accounting for a high rate of infantile morbidity and mortality, and is also a major cause of traveler's diarrhea. Following ingestion of contaminated food or water containing ETEC, the bacteria can attach to the small...
Investigator(s): Zeev Altboum, Myron Levine, Eileen Barry
Categories: Therapeutics, Vaccines
Keyword(s): vaccine, diarrheal
Docket: ZA-2000-053
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Oral live-vector vaccine against Clostridium difficile-associated disease
Published Thursday, May 29, 2014UMB researchers have achieved significant clinical success with live vector vaccines based on attenuated Salmonella enterica serovar Typhi (proven safe in clinical trials). Adapting these typhoid vaccine strains for the delivery of foreign antigens offers exceptional flexibility for further vaccine development. Dr. Jim Galen's group devised...
Investigator(s): James Galen
Categories: Vaccines
Keyword(s): vaccine, C. difficile, oral
Docket: JG-2009-032; JG-2013-037
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Vaccine Enabling Technologies
Published Thursday, May 29, 2014Bacterial live vector vaccines represent a strategy offering exceptional flexibility for vaccine development. In this approach, genes that encode foreign antigens of unrelated bacterial, viral, or parasitic pathogens are expressed in an attenuated bacterial vaccine strain that delivers these foreign antigens to the immune system, thereby...
Categories: Bioengineering, Vaccine
Keyword(s): vaccine
Docket: Multiple Docket Numbers
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Use of Trehalose for Prevention of Neural Tube Defects
Published Thursday, May 29, 2014The neural tube is a specialized part of the embryo that forms the skull, brain and spinal cord in adults and requires an effective balance between cell death and survival. Disruption of this process causes neural tube defects (NTDs) such as spina bifida, anencephaly, and encephalocele. UMB researchers have discovered Trehalose treatment...
Investigator(s): Peixin Yang, E. Albert Reece
Categories: Therapeutics, Small molecules
Keyword(s): Trehalose, diabetes
Docket: PY-2012-118
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Use of Tight Junction Antagonists in the Treatment of Acute Lung Injury and Acute Respiratory Distress
Published Thursday, May 29, 2014Acute Respiratory Syndrome (ARDS) is a severe, life-threatening condition, present in about 150,000 individuals in the US annually with an alarming mortality rate of 30-50% in those affected. To treat ARDS, UMB inventors have developed a specific peptide composition that is deliverable directly to treat excessive leakage within the lungs due to...
Investigator(s): Alessio Fasano, Blake Paterson, Peter Ward
Keyword(s): Acute Respiratory Syndrome, lung, distress
Docket: AF-2011-011