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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Multi-Functional Fluid Flow Device
Published Tuesday, February 21, 2017Cells within a body are exposed to interstitial fluid movements that stimulate morphologic and biochemical cell changes in response to their environment. The fluid flow device is an inexpensive, multifunctional adapter that fit the wells of traditional tissue culture plates to introduce fluid flow shear stress and...
Investigator(s): James Lyon, Joseph Stains, Christopher Ward
Categories: Research Tools, Antibodies, & Reagents, Microfluidics
Keyword(s): Microfluidics, Research Tool
Docket: JL-2016-052
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Determination of Site of Origin Ventricular Tachycardia
Published Wednesday, February 15, 2017Cardiac ablation (CA) is one of three procedures used to treat ventricular tachycardia (VT). CA procedurescan take 6 or more hours to complete. The length of the CA procedure is highly dependent on how quickly the surgeon can pinpoint the VT site of origin (VTSO). The University of Maryland, Baltimore (UMB) researchers have developed a patented...
Investigator(s): Magdi M. Saba, Stephen R. Shorofsky
Categories: Imaging devices
Keyword(s): Cardiac mapping
Docket: MS-2007-102
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Treatment of depression, anhedonia, chronic stress conditions and PTSD with (2R6R)-HNK
Published Thursday, November 10, 2016Ketamine exerts rapid and sustained antidepressant effects after a single dose in patients with depression, but its use is associated with undesirable side effects. With the novel discovery of the actions of ketamine metabolites on the AMPA and not the NMDA glutamate receptors as previously reported,...
Investigator(s): Todd Gould, Panos Zanos, Irving Wainer, Carl Zarate, Craig Thomas, Patrick Morris, Ruin Moaddel
Categories: Therapeutics, Small molecules
Keyword(s): Therapeutic, depression, CNS
Docket: TG-2015-116, TG-2016-107
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Method of Visualizing Drusen in the Eye
Published Thursday, October 27, 2016Drusen are yellow fatty protein deposits under the retina. The formation of drusen increases the risk of a person developing “dry” age-related macular degeneration (dry AMD). The inventor has previously disclosed in published work the surprising finding that these deposits contained tiny hydroxyapatite (HAP)...
Investigator(s): Richard Thompson, Imre Lengyel
Categories: Diagnostics, Imaging
Keyword(s): Ophthalmology, Geriatric, diagnostic
Docket: RT-2012-010, RT-2016-112
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Use of Recombinant Human Activated Protein C to Enhance the Cytoprotective and Anticoagulant Effects of Tissues Transgenic for Human Endothelial Protein C Receptor
Published Tuesday, August 2, 2016Organ transplantation is limited by a critical shortage of donor organs. To address this shortage, clinicians have developed transgenic pigs to express human proteins that regulate rejection, inflammation, and thrombosis. Pigs expressing the human Endothelial Protein C Receptor (hEPCR) is a recent advancement in the...
Investigator(s): Agnes Azimzadeh, Richard Pierson, Donald Harris
Keyword(s): recombinant, Therapeutic, transplant, organ transplant rejection
Docket: DH-2014-019
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Colon-Rectum Temperature Management Devices and Methods
Published Tuesday, August 2, 2016Over the last years, the medical community has accepted that induced therapeutic hypothermia or targeted temperature management as a possible method to achieve cardio-protection and neuro-protection. During emergency care and surgery, inducing hypothermic state may help to reduce swelling, blood loss, and other adverse...
Investigator(s): Bingren Hu, Chunli Liu
Keyword(s): device, surgery
Docket: BH-2015-114
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DART Therapeutic Platform Technology for Treating Fn14-Positive Cancers
Published Monday, June 13, 2016Therapeutic nanoparticles (NPs) approved for clinical use in cancer patients provide only modest improvements in patient survival, likely due to a number of delivery challenges. The discovery of unique cell surface proteins associated with certain tumors has facilitated new approaches for nanocarrier design and payload delivery; specifically,...
Investigator(s): Anthony Kim, Jeffrey Winkles, Graeme Woodworth
Categories: Therapeutics, Nanotechnology + Nanoparticles + Nanomaterials
Keyword(s): blood brain barrier, diagnostic, Therapeutic, brain cancer, nanoparticle
Docket: GW-2014-120; AK-2019-061
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Microtentacle Imaging in Patient Tumor Samples
Published Thursday, June 9, 2016Free floating microenvironments are relevant to many aspects of healthcare and research. However using currently available technologies, it is difficult to utilize non-adherent cells for research and diagnostic purposes due to harsh processing steps (e.g. centrifugation, washing) or artificial substrates (e.g. plastic,...
Investigator(s): Stuart Martin
Keyword(s): circulating tumor cells, diagnostic, cancer
Docket: SM-2013-121. SM-2015-011
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Device and Technique for Placement of Tracheoesophageal Prosthesis Using a Flexible Esophagoscope
Published Wednesday, May 11, 2016Following a laryngectomy, lung-powered voicing is achieved through placement of a one-way valve voice prosthesis using a rigid esophagoscope. This technique for prosthesis placement confers poor visualization. It can also be difficult or impossible to perform on patients with stenosis of the pharynx or esophagus, a...
Investigator(s): Jeffrey Wolf
Categories: Devices, Surgical devices
Keyword(s): Esophagoscope, device, voicebox, prosthesis
Docket: JW-2015-097
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N60-B1.1, a potent broadly neutralizing antibody and HIV-1 vaccine candidate
Published Monday, November 30, 2015Since the discovery of HIV/AIDS in the early 80’s, a considerable amount of effort has been put forth in the development of successful treatment options for patients. One successful treatment option has been the use of broadly neutralizing antibodies isolated from HIV-1 positive donors. Though superior in their protective...
Investigator(s): Yongjun Guan, George Lewis, Anthony DeVico, Mohammad Sajadi, Tongyun Liu, Marzena Pazgier
Keyword(s): HIV, AIDS, vaccine, broadly neutralizing antibody, mutagen, fusion protein
Docket: YG-2013-016