• Device and Method for Measuring In-Cell Protein Folding

  Published Thursday, May 23, 2024

  Summary The 'Device and Method for Measuring In-Cell Protein Folding' introduces the pcIC-FPOP technique, a novel method combining pulse-chase experiments with in-cell protein footprinting and mass spectrometry. This...

  Investigator(s): Dante T. Johnson, Lisa Jones, Anne Gershenson

  Categories: Genomics/Proteomics/Database

  Keyword(s): Protein folding, In-cell footprinting, mass spectrometry, Protein conformation, Protein mis-folding

  Docket: LJ-2018-104

• Functional Myelination of Neurons

  Published Tuesday, May 7, 2024

  Summary This invention is a significant advancement in regenerative medicine, offering a novel stem cell-based therapy for demyelinating diseases. It utilizes melanocyte stem cells (MeSCs) from the skin to differentiate into cells capable of myelination, addressing diseases like...

  Investigator(s): Thomas Hornyak and Sandeep Joshi

  Categories: Therapeutics, Biologics, Stem Cells, Methods of Treatment

  Docket: TH-2015-020

• Adjustable Focus Magnetic Stimulation Coil

  Published Friday, March 22, 2024

  Summary The Adjustable Focus Magnetic Stimulation Coil is a medical device for transcranial or transdermal magnetic stimulation (TMS) promising to enhance treatment of neurological disorders. Its unique coil design permits modulation of magnetic fields to penetrate deeper brain...

  Investigator(s): L. Elliot Hong, Fow-Sen Choa, Qinglei Meng

  Categories: Devices

  Keyword(s): Transcranial Magnetic Stimulation (TMS), Neurological Diseases, Non-invasive Brain Stimulation

  Docket: LH-2019-056

• Compositions and Methods to Evaluate Hepatobiliary/Gastrointestinal Health, Enterohepatic Circulation, and Drug Interactions

  Published Wednesday, March 6, 2024

  Summary The patent describes a novel trifluorinated bile acid analogue, CA-sar-TFMA, designed for use as an imaging probe, diagnostic agent, or contrast agent in evaluating hepatobiliary/gastrointestinal health, enterohepatic circulation, and drug interactions. CA-sar-TFMA's is...

  Investigator(s): James E. Polli, Jean-Pierre Raufman, Diana Vivian

  Categories: Imaging

  Keyword(s): Trifluorinated bile acid analogue, 19F MRI imaging probe, Hepatobiliary health, Gastrointestinal diagnostics, Enterohepatic circulation, Bile acid malabsorption

  Docket: JP-2014-050

• Identification of Toll-Like Receptor 2 (TLR2) Antagonists Using Computer-Aided Drug Design

  Published Wednesday, March 6, 2024

  Toll-like receptors (TLR) are innate immune molecules involved in the detection of microbial and self-ligands released from damaged cells. At their C-termini, toll/interleukin-1 receptor (TIR) domains dimerize upon ligand binding, initiating a signaling cascade that results in the upregulation of inflammatory cytokines. Excessive signaling can...

  Investigator(s): Alexander D. MacKerell, Stefanie N. Vogel

  Categories: Platforms, Therapeutics

  Keyword(s): TLR2, sepsis, anti-inflammation, TIR

  Docket: SV-2010-075

• The Episodic Tool: innovative approach to teach clinical decision making

  Published Monday, March 4, 2024

  Advanced health assessment serves as the foundational course in advanced practice nurse (APN) education in which students apply clinical decision-making skills to gather appropriate subjective and objective data and to begin to formulate diagnostic hypotheses. UMB’s team of professional nurse educators found that APN education...

  Investigator(s): Veronica Quattrini, Amanda Roesch, Katelynn Dougherty Soper

  Categories: Education/Training/Multimedia

  Keyword(s): Teaching tool; Advanced practice nurse education; Advanced health assessment; Clinical judgment

  Docket: VQ-2024-032

• Preventing Metastatic Breast Cancer with Therapeutic Lectin

  Published Monday, March 4, 2024

  UMB inventors led by Prof. Amy Fulton and Prof. David Weber have developed a novel recombinant protein – a lectin known as “rEMSL1” - and elucidated its structure, binding characteristics, and probable mechanism of action. The rEMSL1 construct has been optimized for expression from mammalian cell lines. In...

  Investigator(s): Amy Fulton, David Weber, Raquel Godoy-Ruiz, Namita Kundu

  Categories: Therapeutics

  Keyword(s): Cancer; metastasis; stem cells; biologic; lectin

  Docket: AF-2021-040

• Methods and Systems for Controlling Magnetic Fields and Magnetic Field Induced Current

  Published Monday, February 5, 2024

  Summary The patent US 10,773,096 B2 introduces a novel approach to non-invasive medical treatments, leveraging controlled magnetic fields and currents for deep brain stimulation (DBS). This technology promises enhanced precision in targeting neurological disorders, offering a...

  Investigator(s): Elliot Hong, Fow-Sen Choa

  Categories: Devices

  Keyword(s): Deep brain stimulation (DBS), Transcranial Magnetic Stimulation (TMS), Non-invasive medical treatments, Magnetic field control, Neurological therapy

  Docket: LH-2016-129

• SYSTEM, APPARATUS AND METHOD FOR TRANSIENT ELECTRIC FIELD DETECTION AND DISPLAY

  Published Monday, February 5, 2024

  Summary The patent US 10,758,740 B2 introduces a system for detecting and displaying transient electric fields induced by Transcranial Magnetic Stimulation (TMS). The patent describes a method and system for the precise measurement and visualization of TMS effects,...

  Investigator(s): Elliot Hong, Fow-Sen Choa

  Categories: Devices, Imaging devices

  Keyword(s): Transcranial Magnetic Stimulation (TMS), Electric field detection, Neurology, Psychiatric treatment, Medical device calibration, Brain stimulation

  Docket: LH-2015-028

• Percutaneous Dilation Tracheostomy Device and Method of Using

  Published Monday, December 11, 2023

  Summary The "Percutaneous Dilation Tracheostomy Device and Method of Using" (US 11,497,872 B2) describes a novel percutaneous dilation tracheostomy device. The patented device integrates multiple components into a single unit, enhancing safety and usability. The global...

  Investigator(s): Joseph Rabin

  Categories: Devices, Surgical devices

  Keyword(s): Tracheostomy, Airway Management, medical device, Emergency Care, Tracheal Dilation

  Docket: JR-2017-079

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