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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Zona Incerta Stimulation for Chronic Pain Relief
Published Thursday, May 29, 2014Central pain syndrome (CPS) is a debilitating condition affecting with lesions or dysfunction in the central nervous system. CPS is a neurological disorder resulting from damage to or dysfunction of the pain-conducting pathways of the central nervous system. The patented invention describes a novel method for treating CPS regions of the...
Investigator(s): Asef Keller, Raimi Quiton, Peter Murray, Radi Masri, Jessica Lucas
Categories: Devices, Methods of Treatment
Keyword(s): chronic, pain, device, neurostimulation
Docket: AK-2009-044
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Tight junction permeation enhancer peptides
Published Monday, March 23, 2015Human zonulin or pre-haptoglobin 2 (HP2) is known to reversibly regulate intestinal permeability by modulating intercellular tight junctions. Itactivates protease-activated receptor (PAR) 2, and induces signaling...
Investigator(s): Alessio Fasano, Stefanie N. Vogel
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Small molecules, Biologics, Methods of Treatment
Keyword(s): peptides, zot, zonulin, crohns asthma, glioma, celiac disease, type I diabetes, tight junction
Docket: AF-2004-004
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Protein-Coated Microspheres for the Treatment of Inflammatory Bowel Conditions
Published Tuesday, June 30, 2015Chronic inflammation of the bowel is estimated to affect over 20% of Americans with only a small subset of individuals being clinically diagnosed with the autoimmune diseases Crohn’s and ulcerative colitis (UC). Researchers at the University of Maryland, Baltimore have developed a targeted therapeutic approach that may be...
Investigator(s): Erik P.H. de Leeuw; Wuyuan Lu
Categories: Therapeutics, Biologics, Methods of Treatment
Keyword(s): microsphere, defensin, inflammatory bowel syndrome, inflammatory bowel disease, Crohn's disease, ulcerative colitis, surface-like protein
Docket: ED-2010-131
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Use of ELA peptide for treatment of cardiovascular disease and for improving fluid homeostasis
Published Tuesday, October 20, 2015Cardiovascular disease (CVD) continues to be one of America’s most serious and costly health issues. Though many therapeutic options exist to treat CVD, the majority of treatments address the symptoms of the disease and not the disease itself. This technology is a new class of therapeutic fusion proteins using the hormone Elabela (ELA) to...
Investigator(s): Da-Wei Gong (Lead PI)
Categories: Therapeutics, Biologics, Methods of Treatment
Keyword(s): MI, peptide, heart failure, myocardial infarction, cardiovascular, obesity, ELA, apelin
Docket: DG-2014-128
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Correction of Ischemia with p53 Inhibitors: A Novel Therapeutic Approach to Induce Arteriogenesis
Published Friday, February 24, 2017Severe obstruction of the arteries and reduced blood flow (critical limb ischemia(CLI)) is the advanced stage of peripheral artery disease (PAD). Investigators at UMB have found that Pifithrin-α, a p53 pharmacological inhibitor, improves limb perfusion in diabetic animals, suggesting a therapeutic role in CLI. Tumor-suppressing...
Investigator(s): Rajabrata Sarkar, Mark Hoofnagle, Subhradip Mukhopadhyay
Categories: Therapeutics, Methods of Treatment
Keyword(s): cardiovascular
Docket: RS-2013-040
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Surrogate-Based Prediction Model for Real-Time Tumor Monitoring during Radiotherapy
Published Friday, March 31, 2017To ensure tumor-targeting accuracy over the course of radiation treatment while minimizing the dosimetric impact to healthy tissue, respiratory surrogate models are utilized to monitor tumor position while compensating for tumor motion. These models are developed from a training dataset of concurrent tumor positions and...
Investigator(s): Warren D’Souza PhD
Categories: Software + Algorithm, Healthcare, Methods of Treatment
Keyword(s): radiology; medical imaging; image-guided radiation therapy
Docket: WD-2010-069
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Balanced Reach Control Systems Model
Published Tuesday, May 2, 2017Bipedal standing balance is inherently unstable and must be actively controlled to prevent falling. This involves a complex interaction of the sensorimotor system and multi-segment musculoskeletal system. Fall risk increases with deterioration of sensorimotor and musculoskeletal elements responsible for balance due to age, neurological...
Investigator(s): Joseph E. Barton
Categories: Devices, Imaging devices, Software + Algorithm, Methods of Treatment
Keyword(s): Rehabilitation, balance, reaching, Aging Population
Docket: JB-2016-005, JB-2016-004
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Dichloroacetate and Arsenic Trioxide as an Acute Myeloid Leukemia Combination Therapy
Published Tuesday, May 16, 2017UMB research has been directed at a synergistic combination drug formulation of dichloroacetate and arsenic trioxide to treat AML. AML cells, compared to normal cells, have an increased susceptibility to the disruption of balance of oxidative forces. Selective targeting of the oxidative state, which is a tightly balanced...
Investigator(s): Ashkan Emadi, MD; Rena Lapidus, PhD
Categories: Repurpose Drug, Methods of Treatment
Keyword(s): AML; Acute Myeloid Leukemia; Combination Therapy; Arsenic Trioxide
Docket: AE-2013-045
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Modulation of the Microtubule-Dependent Mechanotransduction as a Therapeutic Intervention in Osteoporosis
Published Thursday, June 28, 2018Bones become thinner and weaker as a consequence of aging. By their mid-30s most individuals have greater bone resorption (bone mass loss) compared to bone formation. Osteoporosis is the result of this loss of bone mass and subsequent changes in bone structure, contributing to skeletal fragility and increased propensity of fractures. Osteocytes...
Investigator(s): Joseph P. Stains, James S. Lyons, Christopher W. Ward
Categories: Methods of Treatment
Keyword(s): Musculoskeletal disorder, bone, osteoporosis
Docket: JS-2017-008
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Device and Method for Transseptal Puncture
Published Wednesday, May 17, 2023Atrial fibrillation (AF) and mitral valve (MV) disease are two of the most common cardiac conditions. AF affects between 2.7 and 6.1 million American adults each year. MV disease is the most common heart valve lesion, impacting 1.7% of U.S. adults (9.3% of people ≥ 75 years old). Both AF and...
Investigator(s): James Gammie, Rachel Quinn, Chetan Pasrija
Categories: Devices, Surgical devices, Methods of Treatment
Keyword(s): Atrial fibrilation, Mitral valve, catheter, Transseptal puncture
Docket: JG-2017-030