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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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1-THP/LDN (low dose Naltrexone) combination as medication for substance dependence disorder
Published Tuesday, May 27, 2014Addiction is a complex and costly disorder that is difficult to treat due to the effects on multiple brain circuits involved in reward and motivation, learning and memory, and inhibitory control over behavior(s). Treatment options remain limited and addiction to alcohol and illicit drugs cause significant problems and economic burden on society...
Investigator(s): Jia Bei Wang, Sarah Sushchyk
Categories: Therapeutics
Keyword(s): Naltrexone
Docket: JW-2012-106
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Antimicrobial Heme Oxygenase Inhibitors and Methods of Use
Published Tuesday, May 27, 2014Antimicrobials are widely used to treat a variety of infections. However, due to overuse and microbial evolution, many antimicrobials are rendered ineffective as first-line therapies. This invention is a new class of broad-spectrum, small-molecule antimicrobials that target the critical enzyme, heme oxygenase that is required to process...
Investigator(s): Angela Wilks, Alexander D. MacKerell, Pedro Lopes, Lena M. Furci
Categories: Therapeutics, Small molecules
Keyword(s): antimicrobial, treatment
Docket: AW-2007-003
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Attenuated Strains of SalmonellaTyphi as Mucosal Live Typhoid Vaccines and Expression Vectors
Published Tuesday, May 27, 2014Salmonella enterica serovar Typhi is the cause of typhoid fever, which remains an important public health problem in many parts of the world. Attenuated strains of S. Typhi were engineered by researchers at UMB's Center for Vaccine Development, and selected strains have proven safe and immunogenic in Phase 1 and Phase 2 human trials. The same...
Investigator(s): Fernando Noriega, Myron Levine, Marcelo Sztein
Categories: Therapeutics, Vaccines
Keyword(s): vaccine
Docket: FN-98-001
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Clostridium difficile Type IV Pilin As New Target for Vaccine, Therapeutics and Diagnostics
Published Tuesday, May 27, 2014Type IV pilin proteins are extracellular and easily accessible to the host immune system, as well as being important for initial colonization and biofilm formation. Thus, these proteins present excellent targets for vaccines to prevent pathogen colonization. Neutralizing antibodies directed against pili could lead to...
Investigator(s): Michael Donnenberg
Categories: Diagnostics, Therapeutics, Vaccines
Keyword(s): vaccine
Docket: MD-2008-081
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Defect-free dendrimer synthesis through proportionate branching
Published Tuesday, May 27, 2014Dendrimers are nanoparticles of synthetic monomers with applications in commercial paints, blood substitutes, nanomaterials, sensor technology. Dendrimers are also building blocks for targeted drug or gene delivery. The dendrimers open architecture forms hollow cavities within the branches that can encapsulate molecules such as drugs or...
Investigator(s): Bruce Yu, Xuyi Yue
Categories: Imaging devices, Diagnostics, Platforms, Therapeutics, Engineering, Biomaterials
Docket: BY-2012-068
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Defensin-like molecules as novel antimicrobial agents
Published Tuesday, May 27, 2014The ever increasing emergence of many pathogenic strains of bacteria resistant to commonly used antibiotics is a rapidly growing concern in public health and new classes of antimicrobial agents are desperately needed. One approach that has gained popularity recently is to study naturally-occurring antimicrobial peptides that have the advantage...
Investigator(s): Erik de Leeuw, Alexander MacKerell
Categories: Diagnostics, Therapeutics
Docket: ED-2012-088, ED-2010-066
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Disruption of the microtubule network as a therapeutic intervention in the muscular dystrophies
Published Tuesday, May 27, 2014Across several muscular myopathies, such as Duchenne muscular dystrophy (DMD), Becker muscular dystrophy, and dysferlinopathies, intercellular signaling cascades such as reactive oxygen signaling (ROS) and calcium (Ca2+) are enhanced and contribute to the onset and pathogenic progression of the myopathy. The discovery of the...
Investigator(s): Christopher Ward, Ramzi Khairallah
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Biologics, Engineering, Bioengineering
Keyword(s): musculoskeletal, rare disease, muscular dystrophy
Docket: CW-2012-040
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IL-25 treatment of obesity and metabolic disorders
Published Tuesday, May 27, 2014Obesity is associated with chronic low grade inflammation in adipose tissues, mainly due to the accumulated immune cells (Th1/Th17 cells, macrophages etc.) that release pro inflammatory cytokines into the system. These cytokines contribute to development of the “metabolic syndrome.” IL-25 is an important regulator in the...
Investigator(s): Aiping M. Zhao, Terez Shea-Donohue
Categories: Therapeutics, Biologics
Keyword(s): IL-25, Biologic, Therapeutic
Docket: AZ-2011-020
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Inhibition of Breast Cancer Metastases using Natural Extracts from Colocasia Esculenta (Taro).
Published Wednesday, May 28, 2014Studies link breast cancer, the second leading cause of cancer-related mortality in US women, with the occurrence of metastatic disease and spread. However, the majority of current therapies focus on the treatment of solid tumors with very little focus on targeting the metastatic process. Due to the significant correlation of secondary tumors...
Investigator(s): Namita Kundu, Amy Fulton
Categories: Therapeutics, Biologics, Natural Compounds
Keyword(s): breast cancer, cancer
Docket: NK-2009-001
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TLR Inhibitors for Treatment of Influenza, Cancer, Allergy, Inflammation and Prevention of Endotoxic Shock
Published Wednesday, May 28, 2014The Toll-like receptors (TLRs) play a vital role in eradicating pathogenic microbial infections, eliminating necrotic host cells and enhancing tissue repair in the host. On the flip side, chronic TLR activation leads to inflammatory disease and “systemic” activation of TLRs may lead to death. ...
Investigator(s): Vladimir Toshchakov
Categories: Research Tools, Antibodies, & Reagents, Platforms, Therapeutics, Biologics
Keyword(s): TLR, decoy peptides, inflammation, cancer, microbial infections, immune disorders, allergy, endotoxic shock, TRAM, TRIF, TIRAP and MyD88
Docket: VT-2012-029 VT-2012-052