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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Identification of Toll-Like Receptor 2 (TLR2) Antagonists Using Computer-Aided Drug Design
Published Wednesday, March 6, 2024Toll-like receptors (TLR) are innate immune molecules involved in the detection of microbial and self-ligands released from damaged cells. At their C-termini, toll/interleukin-1 receptor (TIR) domains dimerize upon ligand binding, initiating a signaling cascade that results in the upregulation of inflammatory cytokines. Excessive signaling can...
Investigator(s): Alexander D. MacKerell, Stefanie N. Vogel
Categories: Platforms, Therapeutics
Keyword(s): TLR2, sepsis, anti-inflammation, TIR
Docket: SV-2010-075
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Compositions and Methods to Evaluate Hepatobiliary/Gastrointestinal Health, Enterohepatic Circulation, and Drug Interactions
Published Wednesday, March 6, 2024Summary The patent describes a novel trifluorinated bile acid analogue, CA-sar-TFMA, designed for use as an imaging probe, diagnostic agent, or contrast agent in evaluating hepatobiliary/gastrointestinal health, enterohepatic circulation, and drug interactions. CA-sar-TFMA's is...
Investigator(s): James E. Polli, Jean-Pierre Raufman, Diana Vivian
Categories: Imaging
Keyword(s): Trifluorinated bile acid analogue, 19F MRI imaging probe, Hepatobiliary health, Gastrointestinal diagnostics, Enterohepatic circulation, Bile acid malabsorption
Docket: JP-2014-050
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Adjustable Focus Magnetic Stimulation Coil
Published Friday, March 22, 2024Summary The Adjustable Focus Magnetic Stimulation Coil is a medical device for transcranial or transdermal magnetic stimulation (TMS) promising to enhance treatment of neurological disorders. Its unique coil design permits modulation of magnetic fields to penetrate deeper brain...
Investigator(s): L. Elliot Hong, Fow-Sen Choa, Qinglei Meng
Categories: Devices
Keyword(s): Transcranial Magnetic Stimulation (TMS), Neurological Diseases, Non-invasive Brain Stimulation
Docket: LH-2019-056
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Functional Myelination of Neurons
Published Tuesday, May 7, 2024Summary This invention is a significant advancement in regenerative medicine, offering a novel stem cell-based therapy for demyelinating diseases. It utilizes melanocyte stem cells (MeSCs) from the skin to differentiate into cells capable of myelination, addressing diseases like...
Investigator(s): Thomas Hornyak and Sandeep Joshi
Categories: Therapeutics, Biologics, Stem Cells, Methods of Treatment
Docket: TH-2015-020