Overview
Cell researchers believe that the efflux of proteins from mitochondria is an activation event that eventually leads to apoptosis.A number of mechanisms have been proposed for the protein permeation pathway. Candidate mechanisms include the ceramide channels.
Researchers at the University of Maryland have a fairly robust model for the structure of the ceramide channel to use in a systematic approach to search for high-affinity compounds (compounds that can influce the formation and disasembly of the channel). They also have a method that could be modified to generate a high throughput screen for such compunds. Additionally, they have identified chemicals that influences the ceramide channel both positively and negatively. The results suggest an anti-apoptotic therapy.
For additional information contact the Office of Technology Commercialization at the University of Maryland 301-405-3947 or by e-mail at [email protected].
Contact Info
UM Ventures
0134 Lee Building
7809 Regents Drive
College Park, MD 20742
Email: [email protected]
Phone: (301) 405-3947 | Fax: (301) 314-9502