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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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1-THP/LDN (low dose Naltrexone) combination as medication for substance dependence disorder
Published Tuesday, May 27, 2014Addiction is a complex and costly disorder that is difficult to treat due to the effects on multiple brain circuits involved in reward and motivation, learning and memory, and inhibitory control over behavior(s). Treatment options remain limited and addiction to alcohol and illicit drugs cause significant problems and economic burden on society...
Investigator(s): Jia Bei Wang, Sarah Sushchyk
Categories: Therapeutics
Keyword(s): Naltrexone
Docket: JW-2012-106
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A Data Visualization Tool to Explore Multidimensional Clinical Datasets
Published Monday, June 19, 2017WinnowTM is an innovative tool to efficiently sift through arrays of longitudinal data, identify patterns, generate hypotheses, and subject these hypotheses to rigorous statistical analysis. It has an intuitive, interactive and insightful platform- valuable to all...
Investigator(s): Lisa Shulman, MD ; Amitabh Varshney, PhD
Categories: Software + Algorithm, Healthcare, Information Technology, Genomics/Proteomics/Database
Keyword(s): Software; Algorithm; Healthcare; Information Technology; Data Analytics
Docket: LS-2017-024
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A Deformable Lung Motion Phantom
Published Friday, March 8, 2019Motion caused by patient breathing can limit the accuracy of the prescribed dose delivered during radiation therapy (RT) especially for cancers in the thorax and abdomen. Sophisticated respiratory motion prediction and real-time motion modeling have been clinically implemented to improve the accuracy and precision of the dose being delivered to...
Investigator(s): Amit Sawant, Maida Ranjbar, Pouya Sabouri, Carlo Repetto
Categories: Devices
Keyword(s): Radiation Oncology
Docket: AS-2018-044
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A Method for Monitoring Cancer and for Regulation of Semaphorin 4D to Improve Cancer Immunotherapy Regimens
Published Monday, May 14, 2018The efficacy of current cancer immunotherapies has been limited by the response of immunosuppressive elements such as myeloid derived suppressor cells (MDSC) and T regulatory cells. Understanding the mechanism behind the suppression of antitumor immunity, and finding ways to revert it, should lead to improved cancer immunotherapy outcomes....
Investigator(s): Rania Younis
Categories: Diagnostics, Biomarker, Therapeutics
Keyword(s): Semaphorin 4D, immunotherapy, oncology, head and neck, cancer
Docket: RY-2015-129
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A stable Receptor-Associated Protein (RAP) protein
Published Tuesday, September 22, 2015A novel Stable Receptor-Associated Protein (RAP), an antagonist of lipoprotein receptor-related protein 1 (LRP1). Dr. Strickland at UMB has developed a stable RAP D3 domain (with 6 mutations) that is resistant to both pH- and heat-induced denaturation. The molecule binds to lipoprotein receptor-related protein 1 (LRP1) with high affinity...
Investigator(s): Dudley Strickland
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): RAP Protein stable
Docket: DS-2015-111
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Adjustable Focus Magnetic Stimulation Coil
Published Friday, March 22, 2024Summary The Adjustable Focus Magnetic Stimulation Coil is a medical device for transcranial or transdermal magnetic stimulation (TMS) promising to enhance treatment of neurological disorders. Its unique coil design permits modulation of magnetic fields to penetrate deeper brain...
Investigator(s): L. Elliot Hong, Fow-Sen Choa, Qinglei Meng
Categories: Devices
Keyword(s): Transcranial Magnetic Stimulation (TMS), Neurological Diseases, Non-invasive Brain Stimulation
Docket: LH-2019-056
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An Automated Medical Student Performance Evaluation Software
Published Friday, September 26, 2014In the United States and Canada, a Medical Student Performance Evaluation (MSPE) is required as part of a medical student’s residency application. The MSPE includes specific information from the student’s academic record including both didactic and clinical courses. The Automated Student Affairs Processes (ASAP) is a user-friendly, platform...
Investigator(s): Kevin Brown, Priyanka Koneru, Sara Menso
Categories: Platforms, Software + Algorithm, Information Technology, Education/Training/Multimedia
Keyword(s): MSPE, software, medical school, administrative office, medical admissions
Docket: KB-2014-002
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Analogs of GHB Lacking GABAergic Activity
Published Monday, February 11, 2019The present invention relates to esthers of 3-hydroxyphenyacetic acid and their use to treat narcolepsy and other sleep disorders. Gamma-hydroxybutyric acid (GHB) is a known agonist for the GHB receptor. Unfortunately it also acts at GABA receptors directly and through its metabolization into alpha aminobutyric acid (GABA). As a result,...
Investigator(s): Andrew Coop, Maharaj Ticku, Charles France
Categories: Therapeutics, Small molecules
Keyword(s): narcolepsy, cataplexy, sleep disorderes
Docket: AC-2006-050
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Analyte Sensor Device and miniaturized Gel Holders, Methods and Systems Utilizing the Same
Published Tuesday, May 27, 2014Bioavailable metal ions (e.g. Cu2+, Zn2+) are essential nutrient required for the normal, healthy growth of plants, animals, and humans. Careful monitoring of these ions is often deployed to gauge levels within the environment to ensure safety as well as functionally adequate concentrations for economical utility. To quickly and easily monitor...
Investigator(s): Richard Thompson
Categories: Devices
Docket: RT-2007-027
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ANALYTE-SENSITIVE PROBES AND CONTACT LENS FOR DIAGNOSIS OF OCULAR PATHOLOGIES
Published Thursday, November 9, 2023Summary The patent introduces a contact lens integrated with analyte-sensitive probes for diagnosing ocular pathologies through the detection of specific analytes in basal tears. This non-invasive, real-time monitoring technology has applications in medical diagnostics and...
Investigator(s): Joseph R. Lakowicz, Ramachandram Badugu, E. Albert Reece
Categories: Devices, Imaging devices, Diagnostics, Imaging, Healthcare
Keyword(s): Analyte-sensitive probes, fluorescence, Diagnostics, Real-time monitoring
Docket: JL-2019-091