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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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A Reliable, High-Yield Method to Grow Uniform Epitaxial Graphene Precursor Layer on SiC
Published Tuesday, July 17, 2018Background:The global market for graphene based products is projected to be 2 billion dollars after the year 2020 at an annual growth rate of 46.3 %. This trend is mainly attributable to graphene’s unique combination of electrical, optical, and mechanical properties, which makes it a top contender for ultra-small, ultra-fast electronics...
Keyword(s): Epitaxial graphene
Docket: PS-2018-015
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An Improved Avian Influenza Vaccine for New Born Chicks
Published Sunday, July 8, 2018Background Avian influenza Virus (AIV) outbreaks not only cause the decimation of broiler and egg-laying chicken populations at once but also result a close to 50% increase in the price of poultry meat and eggs, thereby impacting the end consumer as well. Currently, effective vaccines against AIV are not available. AIV outbreaks are...
Keyword(s): 525
Docket: LS-2017-075
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QUIS™ (Questionnaire for User Interaction Satisfaction)
Published Thursday, July 5, 2018The QUIS™ is an instrument which evaluates user satisfaction with the human-computer interface aspect of other software packages and computer systems. It has been standardized over a number of applications and research studies. The QUIS™ assesses six factors of overall reactions to a system and 21 components which contribute to usability...
Keyword(s): Software development tools (3SOF300), Human computer interaction software (3SOF310)
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Modulation of the Microtubule-Dependent Mechanotransduction as a Therapeutic Intervention in Osteoporosis
Published Thursday, June 28, 2018Bones become thinner and weaker as a consequence of aging. By their mid-30s most individuals have greater bone resorption (bone mass loss) compared to bone formation. Osteoporosis is the result of this loss of bone mass and subsequent changes in bone structure, contributing to skeletal fragility and increased propensity of fractures. Osteocytes...
Investigator(s): Joseph P. Stains, James S. Lyons, Christopher W. Ward
Categories: Methods of Treatment
Keyword(s): Musculoskeletal disorder, bone, osteoporosis
Docket: JS-2017-008
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Inverted Culture Plate Insert for Cellular Co-Culture
Published Wednesday, June 27, 2018Lack of metabolic competence is a major limitation for the majority of current high throughput screening (HTS) assays used for screening drugs, environmental chemicals and industrial compounds for toxicity. As many compounds are metabolically transformed in vivo, toxicity assays should reflect physiologically-relevant metabolism to accurately...
Investigator(s): Bryan Mackowiak, Hongbing Wang, Linhao Li
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): research tools
Docket: BM-2017-002
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Selective RARγ Ligand-loaded Nanoparticles for Manipulation of Targeted Bone Growth
Published Wednesday, June 27, 2018Imbalance in bone length, caused by congenital conditions or fractures, can result in progressive deformity and physical problems. To date, the only way to adjust these bone length problems are surgical procedures. UMB researchers have identified a nuclear retinoid receptor, RARγ, which controls the rate of transition from cartilage to...
Investigator(s): Masahiro Iwamoto, Michael Chorny
Categories: Therapeutics, Other
Keyword(s): Orthopedics, Therapeutics Drug Delivery System
Docket: MI-2017-124
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Predicting Success of Pharmaceuticals for Cancer Treatments via Synthetic Rescues
Published Thursday, May 24, 2018A framework that tracks resistance to cancer treatments to predict the likelihood of success in the treatment of cancer in individual patients. The framework can be used to decide the best method of treatment for patients and can also be applied to developing new forms of cancer treatment and refining the design of already existing treatments that...
Keyword(s): bioinformatics, cancer, cancer treatment, synthetic rescues, resistance
Docket: IS-2015-119
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Liquid Biopsy Test for Early Detection of Lung Cancer
Published Wednesday, May 23, 2018Low-dose computed tomography (LDCT) is recommended for annual screening by the US Preventive Services Task Force, and the test is reimbursed by Medicare (see below). LDCT is intended for early detection of cancer, but unfortunately has a high false-positive rate (i.e., it detects indeterminate pulmonary nodules (PNs), 96% of...
Investigator(s): Feng Jiang
Categories: Diagnostics
Keyword(s): oncology, Diagnostics
Docket: FJ-2016-076, FJ-2017-097
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A Method for Monitoring Cancer and for Regulation of Semaphorin 4D to Improve Cancer Immunotherapy Regimens
Published Monday, May 14, 2018The efficacy of current cancer immunotherapies has been limited by the response of immunosuppressive elements such as myeloid derived suppressor cells (MDSC) and T regulatory cells. Understanding the mechanism behind the suppression of antitumor immunity, and finding ways to revert it, should lead to improved cancer immunotherapy outcomes....
Investigator(s): Rania Younis
Categories: Diagnostics, Biomarker, Therapeutics
Keyword(s): Semaphorin 4D, immunotherapy, oncology, head and neck, cancer
Docket: RY-2015-129
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Sailfish - A System for Estimating Gene Expression from RNA-Seq Reads
Published Thursday, May 3, 2018Sailfish implements an efficient, accelerated expectation-maximization algorithm for quantifying isoform abundance that produces high-quality results, and is capable of correcting numerous types of systematic bias that are known to occur in RNA-seq experiments. In the paper, we demonstrate that, on both real and synthetic data, Sailfish is as...
Categories: Software + Algorithm
Keyword(s): RNA, Gene Expression, estimation, open, source
Docket: IS-2017-155