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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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A Novel Discretely Actuated and Steerable Probe for Percutaneous Procedures
Published Monday, May 24, 2010BackgroundIn diagnostic and therapeutic medical procedures such as biopsy and radiofrequency ablation, a needle is used to reach a predetermined target. When flexible, bevel-tipped needles are inserted into soft tissue, they bend due to tip asymmetry, often resulting in targeting errors. Innovative TechnologyTo improve steering...
Categories: Imaging devices, Imaging
Keyword(s): needle, cannula, probe, biopsy, tissue, target
Docket: PS-2010-048
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A Novel Dual Reporter System
Published Tuesday, August 23, 2005Fluorescent proteins are genetically encoded, easily imaged reporters crucial in cell biology and biotechnology. Fluorescent proteins make possible the relatively straightforward study of proteins within living cells and are very valuable research tools. Researchers at the Department of Cell Biology and Molecular Genetics, University...
Categories: Imaging devices
Keyword(s): fluorescent kit, Fluorescence, reporter, protein
Docket: LS-2005-031
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A Novel Method for Identification of Microorganisms/Cells
Published Tuesday, October 16, 2001Researchers on campus have developed a rapid method for identification of microorganisms. The method involves comparing the mass spectrum of a set or mixture of unknown proteins against publicly available database protein collections assembled from known organisms. Molecular mass is used for comparisons and hence only pico molar amounts of sample...
Categories: Genomics/Proteomics/Database
Keyword(s): protein, mass spectrometry, homeland
Docket: LS-98-089
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A Novel Method for Production of Rare Carotenoids from Commercially Available Lutein
Published Tuesday, July 21, 2015Anhydrolutein, a-cryptoxanthin, b-cryptoxanthin and zeaxanthin are among the 12 major dietary carotenoids which are found in human serum, milk, major organs, and tissues. Industrial production of a wide range of purified carotenoids is of great importance in view of the role of carotenoids in the prevention of chronic diseases like cancer, age-...
Categories: Natural Compounds
Keyword(s): Nutraceutical
Docket: LS-2000-040
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A Novel Method or Colloidal Gel Preparation Useful for Surgical Embolization
Published Monday, February 26, 2018Background Colloidal gels- mixture of two or more substances that neither dissolve nor settle down in solution- can be generated by mixing two or more substances together that can form intricate mesh-like networks. These networks are sustained through various chemical interactions such as hydrogen bonds, electrostatic interactions or...
Categories: Drug delivery devices, Biomaterials
Keyword(s): 525
Docket: LS-2017-048
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A Novel Salmonella Strain For Vaccinating Chicken
Published Wednesday, April 12, 2017Background Salmonella outbreaks among poultry flocks result not only in direct losses to the farmer but also indirect costs to the entire industry due to loss of consumer confidence at the break of news about an outbreak. According to Center for Disease Control (CDC), 8 known outbreaks resulted in the US in 2016 alone. The passage of...
Keyword(s): Salmonella vaccine, chicken, poultry, 525
Docket: LS-2016-186
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A Novel Target for Antiviral Therapeutics
Published Monday, February 2, 2004The propagation of many important viruses depends upon the availability of precise ratios of viral proteins as determined by the efficiency of programmed ribosomal frameshifting (PRF). Thus a better understanding of the molecular mechanisms underlying the control of PRF can contribute toward new targets for the rational design of antiviral...
Categories: Vaccines, Biologics
Keyword(s): antiviral, translational termination
Docket: LS-2003-049
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A Novel Technique for Eliminating Edge Artifacts in Magnetic Microscopy
Published Wednesday, March 22, 2006Magnetic Inverse techniques used to detect faults in microelectronic structures allow a two dimensional magnetic field image produced to be converted into a current-density map. However, discontinuities in the magnetic field image at the edges of the image can lead to undesirable "ripple" artifacts (noise or interference) in the resulting map...
Categories: Imaging devices
Keyword(s): edge-artifacts magnetic field mircowave microscope
Docket: PS-2003-063
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A Novel Vector to Assay Translational Recoding
Published Tuesday, April 11, 2017Background Translational recoding is a mechanism typically employed by viruses to achieve efficient production of proteins required for assembly and replication. Operationally, translational recoding employs unique 3-dimensional RNA structures that drive ribosomes to slip “out of frame” (Programmed Ribosomal Frameshifting) or to bypass stop...
Keyword(s): ribosomal frameshifting, trasnlational recoding, efficiency monitoring, reporter vector, Fluorescence, quantitative measurement
Docket: LS-2016-091
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A Power Constrained, High Performance, Multi-Rank DDRx SDRAM Scheduling Algorithm
Published Sunday, January 23, 2005Power consumption and heat dissipation considerations are constraining high performance DRAM memory systems just as they are constraining high performance processors. The combination of power limitation and data bus synchronization constraints will limit available memory bandwidth in DDR2 and future DDR3 SDRAM memory systems that do not adequately...
Categories: Information Technology
Keyword(s): power, heat ,dram memory, bandwidth optimized DRAM transaction and command scheduling algorithms
Docket: IS-2005-004