Selective Small Molecule Inhibitors Targeting Protein Translation in Cancer Cells

Dysregulated protein translation is a hallmark of tumorigenesis, making it an appealing  therapeutic target. However, current therapies are constrained by systemic toxicity, poor selectivity, and drug resistance. This technology offers a more selective approach to targeting...

Investigator(s): France Carrier, Alexander D. MacKerell, David J. Webber, Wenbo Yu

Categories: Biomarker, Therapeutics, Small molecules

Docket: FC-2019-108

Therapeutic Targets to Overcome CAR-T Immune Evasion in Cancer Relapse

CAR-T cell immunotherapies are constrained by relapse and reduced efficacy due to antigen escape, poor tumor infiltration, and T-cell exhaustion. This technology offers an adaptable approach to overcome these resistance mechanisms by enhancing anti-tumor activity and overall therapeutic performance. Building on existing CAR-T platforms, it represents a promising advancement with strong potential in a competitive immunotherapy market.

Investigator(s): Tim Luetkens, Kenneth A. Dietze

Categories: Research Tools, Antibodies, & Reagents, Biologics, Methods of Treatment

Docket: TL-2024-004

Enhanced In Vivo Genome Editing Using Cas9 Fusion Proteins

A novel, high-performance double-strand break (DSB) repair-based editing agent, Cas9 fusion protein (Cas9-RC), shows unmatched efficiency and precision for in vivo genome editing. PROBLEM ADDRESSED Genome editing is a powerful technology that allows for the specific and often precise addition or removal...

Investigator(s): Alexandros Poulopoulos; Ryan Richardson; Colin Robertson

Categories: Research Tools, Antibodies, & Reagents, Therapeutics

Docket: AP-2023-076

Prognostic to Treat Ovarian Cancer and Predict Responsiveness to Treatment

This technology assesses ZNFX1 expression to guide treatment strategy and predict responsiveness to anti-cancer therapies in ovarian cancer. PROBLEM ADDRESSED Ovarian cancer represents the most fatal...

Investigator(s): Feyruz Rassool; Lora Stojanovic; Boris Winterhoff (Univ of Minn); Stephen B. Baylin (JHU) Kenneth P. Nephew (IU School of Med)

Categories: Diagnostics, Biomarker

Keyword(s): biomarker, ovarian cancer, diagnostic, ZNFX1, prognostic

Docket: FR-2024-066

Eosinophil-Targeting Methods for Improving Recovery after Lung Resection

Targeted depletion of eosinophils using FDA-approved antibody-based therapies uncovers an innovative approach to improve recovery and post-operative outcomes after pulmonary procedures such as lung resection. ...

Investigator(s): Alexander Sasha Krupnick; Zhongcheng Mei; Elizabeth Jacobsen

Keyword(s): Therapeutic, Biologic, Eosinophil, Pulmonary Surgery, Postoperative Management

Docket: AK-2023-047

MK-2022-126: INHIBITORS OF PDE11A AND METHODS OF USING SAME

Phosphodiesterase 11A4 (PDE11A4) is a dual‑specificity enzyme that degrades cAMP and cGMP and has been linked to associative long‑term memory decline. The patent discloses heterocyclic small molecules built on a triazine core that selectively inhibit PDE11A4 and alter its subcellular localization. By elevating cyclic nucleotides and disrupting...

Investigator(s): Shams ul Mahmood, Michele Patrice Kelly, David Rotella

Categories: Therapeutics, Small molecules

Keyword(s): PDE11A inhibitor, cognitive decline, Memory, Neurodegenerative disorders

Docket: MK-2022-126

MM-2017-117: A SYSTEM FOR NONDESTRUCTIVE SPECTROSCOPIC ANALYSIS OF BIOLOGIC SPECIMENS

Summary This invention describes a portable optical system for nondestructive, in situ spectroscopic analysis of biological fluids such as blood, urine, and cerebrospinal fluid (CSF). The system operates within a sterile fluid conduit—such as catheter tubing or specimen vials—without requiring...

Investigator(s): Michael T. McCurdy; Rajagopal Srinivasan

Categories: Diagnostics

Keyword(s): inline spectroscopy, catheter-integrated sensors, optical rail, UV-Vis-NIR, fluorescence, bedside analytics, tele-ICU integration.

Docket: MM-2017-117

RB-2015-062: Regulating Calcium in Excitable Cells with a Novel Protein

Summary  The patent (US 10,543,252 B2) granted to the University of Maryland, Baltimore details methods and compositions for regulating calcium homeostasis in...

Investigator(s): Patrick F. Desmond; Robert J. Bloch; Mark A. Rizzo; Joaquin Muriel; Michele L. Markwardt

Categories: Therapeutics, Biologics

Keyword(s): sAnk1, SERCA1, sarcolipin, calcium regulation, muscular dystrophy, cardiomyopathy, siRNA therapy, AAV gene therapy

Docket: RB-2015-062

MF-2020-143: Therapeutics Against Pathogenic Coronaviruses

Summary This invention involves the development of PIKfyve inhibitors as therapeutic compounds to treat infections caused by SARS-CoV-2 and related coronaviruses. By specifically inhibiting lysosomal function, these compounds disrupt viral replication, offering a novel...

Investigator(s): Matthew B. Frieman. Melvin L. DePamphilis, Arup R. Chakraborty

Categories: Therapeutics, Biologics

Keyword(s): SARS-CoV-2, PIKfyve inhibitors, Coronavirus treatment

Docket: MF-2020-143

BG-2022-020: MODULAR, PERCUTANEOUS DUAL-LUMEN CANNULA SYSTEM

Executive Summary The Modular, Percutaneous Dual-Lumen Cannula System is designed to improve cardiovascular access for ECMO, RVAD support, and intensive care cannulation. Traditional dual-lumen cannulas have fixed port distances, which limit...

Investigator(s): Bartley Griffith, Zhongjun Wu, Chetan Pasrija, Aakash Shah, Zachary Kon

Categories: Devices, Surgical devices

Keyword(s): adjustable cannula, dual-lumen, ECMO, RVAD, Critical Care

Docket: BG-2022-020