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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Prompt Gamma Imaging System for Proton Range Verification using a Compton Camera
Published Tuesday, December 12, 2017Range uncertainty in the exact position of the distal dose gradient of a proton beam delivered within a patient during radiotherapy (RT) can lead to underdosing of the tumor or to excessive dosing to adjacent healthy tissues or critical organs at risk. The unwanted side effects and complications due this uncertainty is...
Investigator(s): Jerimy Polf
Keyword(s): Radiation Oncology, Medical Imaging, Theranostics, Radio-isotope monitoring/imaging, Prompt Gamma Imaging System
Docket: JP-2017-058, JP-2016-088, JP-2015-137
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Wnt Signaling Inhibitors for the Treatment of Diabetes
Published Tuesday, December 12, 2017The Wnt/β-catenin signaling pathway plays a pivotal role in cell proliferation and differentiation through the regulation of the transcriptional factor β-catenin. The Wnt pathway has been studied extensively for cancer (colon, liver) but the role of the Wnt...
Investigator(s): Fengtian Xue, Yan Shu
Keyword(s): Metabolic Disease, diabetes, small molecule inhibitor
Docket: FX-2015-082
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Automated evaluation of surgeon technical performance
Published Wednesday, November 15, 2017The technical skills of a surgical resident are typically evaluated by experienced mentors during training. However, this process is time-consuming, labor-intensive and may involve evaluator biases. In an effort to standardize such technical evaluations, UMB researchers developed an automated, sensor-free...
Investigator(s): Colin Mackenzie, Peter Hu, Shiming Yang, Evan Garofalo
Categories: Software + Algorithm, Education/Training/Multimedia
Keyword(s): surgery, education, assessments
Docket: CM-2016-014
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The HIV Transgenic (Male/Female) Rat, HIV type 1 (HIV-1) transgenic (Tg) rat on the Fisher 344 background
Published Thursday, November 2, 2017The HIV-1 Tg rat exhibits expression of the transgene, consisting of an HIV-1 provirus with a functional deletion of gag and pol, is regulated by the viral long terminal repeat. Spliced and unspliced viral transcripts were expressed in lymph nodes, thymus, liver, kidney, and spleen, suggesting that Tat and Rev are...
Investigator(s): Joseph Bryant, William C Reid, Harry G.Davis Jr.
Categories: Biomaterials
Keyword(s): biological materials, HIV-1
Docket: JB-2010-136-1
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Histatin-5-Based Antifungal Peptides for Oral Topical Applications
Published Tuesday, October 31, 2017Candida albicans is a fungus colonizing human mucosal surface. It commonly causes recurrent infections which can become life-threatening in immunosuppressed and immunocompromised patients. Histatin-5 (Hst-5) is a cationic antimicrobial peptide found in saliva with antifungal activity against C. albicans, related fungal...
Investigator(s): Mary Ann Jabra-Rizk, Amy Karlsson, Timothy F. Meiller
Categories: Therapeutics, Biologics
Keyword(s): Candida, fungus, Biofilm, antimicrobial
Docket: MR-2016-100
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Prednisone Taper Calculator: Steroid Taper Calculator for the Treatment of Immune Adverse Reactions to Immune Checkpoint Inhibitors
Published Wednesday, October 4, 2017Immune check-point inhibitors (ICPI) in combination with immunotherapies have been successful in treating solid tumors. However, 7-60% of patients using the ICPI combination therapy experience side effects, which can manifest as autoimmune attacks and can potentially become life threatening. The side effects can be treated successfully...
Investigator(s): Petr Hausner
Keyword(s): Healthcare IT, software
Docket: PH-2017-020
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Image Analysis of Circulating Tumor Cell MicroTentacles
Published Wednesday, October 4, 2017The study of circulating tumor cells (CTC) is of considerable interest because of their prognostic value and for therapeutic development. One interesting morphological aspect of CTCs is the presence of microtentacles. Microtenticles are protusions found on the CTCs that are thought to be critically important for...
Investigator(s): Stuart Martin (UMB), Wolfgang Losert (UMCP)
Categories: Software + Algorithm
Keyword(s): software, assay, oncology
Docket: SM-2018-015
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Therapy Regimen and Methods to Reprogram Cancer Cells and Sensitize Multiple Cancers to PARP Inhibitors
Published Tuesday, September 19, 2017Epigenetics is the regulation of genomic functions including the reversible modification of gene expression through DNA methylation and histone modifications (acetylation, methylation, phosphorylation). Dysregulation of epigenetic modifications can lead to the development of diseases. However, due to the reversible...
Investigator(s): Feyruz Rassool, Stephen Baylin, Carine Robert, Nidal Muvarak, Khadiz Chowdhury
Keyword(s): oncology, epigenetic, combination therapy
Docket: FR-2013-075
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A Data Visualization Tool to Explore Multidimensional Clinical Datasets
Published Monday, June 19, 2017WinnowTM is an innovative tool to efficiently sift through arrays of longitudinal data, identify patterns, generate hypotheses, and subject these hypotheses to rigorous statistical analysis. It has an intuitive, interactive and insightful platform- valuable to all...
Investigator(s): Lisa Shulman, MD ; Amitabh Varshney, PhD
Categories: Software + Algorithm, Healthcare, Information Technology, Genomics/Proteomics/Database
Keyword(s): Software; Algorithm; Healthcare; Information Technology; Data Analytics
Docket: LS-2017-024
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Rational Targeting of Protein Translation in Cancer Cells
Published Wednesday, June 14, 2017Deregulation of protein translation is associated with a growing number of human diseases, including tumorigenesis. The mammalian mTOR pathway has garnered considerable interest as a major target for new anti-cancer therapies due to its key role in regulating cell growth. However, clinical applications have been limited due to the role of this...
Investigator(s): France Carrier
Categories: Therapeutics
Keyword(s): oncology, mROR
Docket: FC-2015-047