Search Technologies
Displaying 1 - 10 of 42 results
Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
Search by keyword:
-
Disruption of the microtubule network as a therapeutic intervention in the muscular dystrophies
Published Tuesday, May 27, 2014Across several muscular myopathies, such as Duchenne muscular dystrophy (DMD), Becker muscular dystrophy, and dysferlinopathies, intercellular signaling cascades such as reactive oxygen signaling (ROS) and calcium (Ca2+) are enhanced and contribute to the onset and pathogenic progression of the myopathy. The discovery of the...
Investigator(s): Christopher Ward, Ramzi Khairallah
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Biologics, Engineering, Bioengineering
Keyword(s): musculoskeletal, rare disease, muscular dystrophy
Docket: CW-2012-040
-
Fluorescence-Based Assay to Screen for Mitochondrial Protective Compounds
Published Tuesday, May 27, 2014The UMB inventors have developed an enzymatic assay which is a sensitive method for detecting mitochondrial damage. It is based on coupled enzymatic reactions that produce a detectable fluorescence signal in the presence of the reduced or oxidized form of nicotinamide adenine dinucleotide (NADH/NAD) and can detect nanomolar levels of pyridine...
Investigator(s): Tibor Kristian, Gary Fiskum
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): research tools
Docket: TK-2004-007
-
TLR Inhibitors for Treatment of Influenza, Cancer, Allergy, Inflammation and Prevention of Endotoxic Shock
Published Wednesday, May 28, 2014The Toll-like receptors (TLRs) play a vital role in eradicating pathogenic microbial infections, eliminating necrotic host cells and enhancing tissue repair in the host. On the flip side, chronic TLR activation leads to inflammatory disease and “systemic” activation of TLRs may lead to death. ...
Investigator(s): Vladimir Toshchakov
Categories: Research Tools, Antibodies, & Reagents, Platforms, Therapeutics, Biologics
Keyword(s): TLR, decoy peptides, inflammation, cancer, microbial infections, immune disorders, allergy, endotoxic shock, TRAM, TRIF, TIRAP and MyD88
Docket: VT-2012-029 VT-2012-052
-
Multicellular Organotypic Tissue Engineering of the Human Intestinal Mucosa
Published Wednesday, May 28, 2014The engineering of a three-dimensional (3D) multicellular organotypic model of the human intestinal mucosa has a wide ranging potential as a tool for discovery of both health and diseases, such as interactions with pathogens, antigen trafficking, inflammatory processes, and tissue bioengineering. To more appropriately mimic an in vivo...
Investigator(s): Rosangela Mezghanni, Marcelo B. Sztein, Alessio Fasano
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): intestinal mucosa, Organotypic
Docket: RM-2011-031
-
Myo Tak
Published Wednesday, May 28, 2014In the field of striated and smooth muscle biology, the study of the mechanical properties of muscle has relied almost exclusively on multi-cellular preparations (whole muscles or muscle strip preparations). These preparations allow for tying, clipping, or clamping of muscle tissue to mechanical apparatus via tendon or bone attachment. Single...
Investigator(s): Christopher W. Ward, Jonathon Lederer, Benjamin L. Prosser, George Rodney, Luke Michaelson
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): research tools
Docket: CW-2010-065
-
NON-HEMOLYTIC CLYA FOR PROTEIN EXPORT AND VACCINES
Published Wednesday, May 28, 2014This technology is a specialized protein export system for efficiently producing recombinant protein from a host cell while optimizing safety for use with live vector vaccines, and is related to that described in Docket Code JG-2001-022. The UMB inventors have engineered a genetically stabilized expression plasmid incorporating the protein of...
Investigator(s): James Galen, Yuansha Chen
Categories: Research Tools, Antibodies, & Reagents
Docket: JG-2008-080
-
Novel multidrug resistance transporter isolated from human breast cancer cells.
Published Wednesday, May 28, 2014The ATP binding cassette (ABC) transporters are the largest family of transmembrane proteins and involved in conferring multidrug resistance (MDR) to cancers, often causing the failure of cancer treatments. The discovery of Breast Cancer Resistance Protein (BCRP)/...
Investigator(s): Douglas Ross, Doyle L. Austin, Lynne Abruzzo
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): breast cancer, cancer, BCRP, chemotherapy
Docket: DR-97-047
-
Pluripotent Stem Cell Production Method
Published Wednesday, May 28, 2014One of the major hurdles in stem cell research is that techniques for purification and propagation can be tedious and result in low yields. Standard methods require feeder cells, matrix, and serum, which are expensive and can introduce contaminants. UMB researchers, however, have developed an alternative method to consistently and reliably...
Investigator(s): G. David Trisler, Bernard M. Pessac, Christopher T. Bever Jr., James E. Goolsby
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Stem Cells
Keyword(s): stem cell
Docket: GT-2004-009
-
SILCS: Site Identification by Ligand Competitive Saturation. Method for binding site identification by molecular dynamics simulation
Published Thursday, May 29, 2014The present invention is directed to a method of computational chemistry for identifying binding sites by molecular dynamics simulations using ligand competitive saturation. Fragment-based drug discovery relies on a simple premise: identify small molecule fragments that bind to a target region of a large molecule and then evolve or link the...
Investigator(s): Alex MacKerell Jr., Olgun Guvench
Categories: Research Tools, Antibodies, & Reagents, Software + Algorithm
Keyword(s): simulation, drug design
Docket: AM-2009-054
-
Targeted Conditional Expression of Proteins to Cell-Type
Published Thursday, May 29, 2014Mitochondrial dysfunction has been implicated in the pathogenesis of a plethora of neurodegenerative disorders (e.g., stroke, Parkinson's, amyotrophic lateral sclerosis, Huntington's, Alzheimer's, etc.). However, effective models useful for elucidating mechanisms and therapies associated with neuronal mitochondrial dysfunction are lacking. This...
Investigator(s): Krish Chandrasekaran, Tibor Kristian
Categories: Research Tools, Antibodies, & Reagents
Docket: KC-2006-026