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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Silicon Hydrogel Contact Lenses with Embedded Assay Components for Tear Fluid Clinical Assays
Published Wednesday, November 15, 2023Summary The "Silicon Hydrogel Contact Lenses with Embedded Assay Components for Tear Fluid Clinical Assays" patent describes an advancement in non-invasive medical diagnostics. It integrates clinical assay components into contact lenses for real-time tear fluid analysis, catering...
Investigator(s): Joseph R. Lakowicz, Ramachandram Badugu, E. Albert Reece
Categories: Imaging devices, Diagnostics, Biomarker, Healthcare
Keyword(s): non-invasive monitoring, clinical assays, biomarkers, medical diagnostics
Docket: JL-2021-074
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Silicone Hydrogel Based Fluorescent Assay and Contact Lens
Published Wednesday, November 8, 2023Summary The "Silicone Hydrogel Based Fluorescent Assay and Contact Lens" patent introduces a novel technology for non-invasive medical diagnostics. It integrates a fluorescent assay into a silicone hydrogel contact lens, enabling real-time glucose monitoring in tear fluid. This...
Investigator(s): Joseph R. Lakowicz, Ramachandram Badugu, E. Albert Reece
Categories: Devices, Diagnostics, Biomarker
Keyword(s): fluorescent assay, Glucose Monitoring, analyte detection, biomarker monitoring, diabetes
Docket: JL-2016-128
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DIAGNOSIS AND PROGNOSIS OF MULTIPLE SCLEROSIS
Published Tuesday, October 31, 2023Summary: The patent introduces a novel method for determining whether an individual with relapsing-remitting multiple sclerosis (RRMS) will experience a relapse or respond positively to specific treatments. By analyzing the ratio of mRNA levels of Response Gene to Complement-32...
Investigator(s): Horea Rus, Cornelia Cudrici, Cosmin Tegla
Categories: Diagnostics, Biomarker
Keyword(s): Multiple Sclerosis, Diagnosis, Prognosis
Docket: HR-2010-081, HR-2015-030
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A Method for Monitoring Cancer and for Regulation of Semaphorin 4D to Improve Cancer Immunotherapy Regimens
Published Monday, May 14, 2018The efficacy of current cancer immunotherapies has been limited by the response of immunosuppressive elements such as myeloid derived suppressor cells (MDSC) and T regulatory cells. Understanding the mechanism behind the suppression of antitumor immunity, and finding ways to revert it, should lead to improved cancer immunotherapy outcomes....
Investigator(s): Rania Younis
Categories: Diagnostics, Biomarker, Therapeutics
Keyword(s): Semaphorin 4D, immunotherapy, oncology, head and neck, cancer
Docket: RY-2015-129
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Use of Biomarkers for Assessing Differential Risk for Developing Heart Failure Phenotypes
Published Wednesday, April 5, 2017Left ventricular (LV) hypertrophy (LVH), most commonly due to chronic hypertensive heart disease, is associated with increased risk of developing depressed LV systolic function, heart failure (HF) and death. Routine cardiac imaging to screen for LVH in hypertensive patients is not recommended because...
Investigator(s): Christopher deFilippi, James de Lemos, Robert H. Christenson, Stephen L. Seliger
Categories: Diagnostics, Biomarker
Keyword(s): biomarker, heart failure, Diagnostics
Docket: CD-2014-098
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Compositions and Methods for Determining the Likelihood of Appendicitis
Published Tuesday, August 25, 2015Appendicitis is a condition that is easily treated through the surgical removal of the appendix. However, delays in diagnosis beyond 24-36 hours from the start of symptoms can lead to an increased risk of mortality, morbidity, and costs due to complications. Diagnosis is complicated by the heterogeneous clinical presentation of...
Investigator(s): Anthony Sandler, Claire M. Fraser, Emmanuel Mongodin, Hope Jackson, Katherine Davenport, Steven L. Zeichner
Categories: Diagnostics, Biomarker, Genomics/Proteomics/Database
Keyword(s): Appendicitis, Appendix, Microbiota, bacteria
Docket: CF-2014-074
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HSP90 as a Biomarker for Malignancies
Published Tuesday, May 27, 2014Heat Shock protein 90 (Hsp90)` a molecular chaperone` has shown to have a great potential as an anti-cancer target. Hsp90 antagonists (e.g. 17AAG) have emerged as promising drugs that inhibit tumor cell growth by affecting the ability of Hsp90 to fold associated molecules important in cancer growth and progression. The invention relates to...
Investigator(s): Angelika Burger, Edward Sausville
Categories: Diagnostics, Biomarker
Docket: AB-2007-015
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Borrelia Burgdorferi Genetic Markers for Lyme Disease Diagnostics
Published Thursday, April 16, 2009BackgroundDiagnosing Lyme disease is notoriously difficult for physicians and veterinarians. Available tests have improved significantly over the last few decades but still leave much room for increased accuracy of results. As the genetic design of Lyme disease pathogen Borrelia burgdorferi is more fully understood, diagnostic kits may be...
Categories: Diagnostics, Biomarker
Keyword(s): Lyme Disease, Borrelia burgdorferi, B. burgdorferi, vaccine, diagnostic markers
Docket: LS-2009-015