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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Clostridium difficile Type IV Pilin As New Target for Vaccine, Therapeutics and Diagnostics
Published Tuesday, May 27, 2014Type IV pilin proteins are extracellular and easily accessible to the host immune system, as well as being important for initial colonization and biofilm formation. Thus, these proteins present excellent targets for vaccines to prevent pathogen colonization. Neutralizing antibodies directed against pili could lead to...
Investigator(s): Michael Donnenberg
Categories: Diagnostics, Therapeutics, Vaccines
Keyword(s): vaccine
Docket: MD-2008-081
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Defect-free dendrimer synthesis through proportionate branching
Published Tuesday, May 27, 2014Dendrimers are nanoparticles of synthetic monomers with applications in commercial paints, blood substitutes, nanomaterials, sensor technology. Dendrimers are also building blocks for targeted drug or gene delivery. The dendrimers open architecture forms hollow cavities within the branches that can encapsulate molecules such as drugs or...
Investigator(s): Bruce Yu, Xuyi Yue
Categories: Imaging devices, Diagnostics, Platforms, Therapeutics, Engineering, Biomaterials
Docket: BY-2012-068
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Defensin-like molecules as novel antimicrobial agents
Published Tuesday, May 27, 2014The ever increasing emergence of many pathogenic strains of bacteria resistant to commonly used antibiotics is a rapidly growing concern in public health and new classes of antimicrobial agents are desperately needed. One approach that has gained popularity recently is to study naturally-occurring antimicrobial peptides that have the advantage...
Investigator(s): Erik de Leeuw, Alexander MacKerell
Categories: Diagnostics, Therapeutics
Docket: ED-2012-088, ED-2010-066
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HSP90 as a Biomarker for Malignancies
Published Tuesday, May 27, 2014Heat Shock protein 90 (Hsp90)` a molecular chaperone` has shown to have a great potential as an anti-cancer target. Hsp90 antagonists (e.g. 17AAG) have emerged as promising drugs that inhibit tumor cell growth by affecting the ability of Hsp90 to fold associated molecules important in cancer growth and progression. The invention relates to...
Investigator(s): Angelika Burger, Edward Sausville
Categories: Diagnostics, Biomarker
Docket: AB-2007-015
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High affinity recombinant sea lamprey antibodies selected by a yeast surface display platform.
Published Tuesday, May 27, 2014Immunoglobulin-based antibody therapeutics are enjoying unprecedented success. Hundreds are in clinical trials, with revenues from the top five (Rituxan, Remicade, Herceptin, Humira, and Avastin) increasing from $6.4 billion in 2004 to $11.7 billion in 2006 (Dimitrov & Marks, 2009). Thousands more are available for biological detection...
Investigator(s): Zeev Pancer, Roy Mariuzza, Satoshi Tasumi, Carlos Velikousky
Categories: Diagnostics, Platforms
Docket: ZP-2010-085
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Inhibitors of S100 Proteins for the Treatment of Cancer and Other Diseases Involving Uncontrolled Cell Growth via an S100-Dependent Pathway
Published Wednesday, May 28, 2014Small molecules have been identified, using rational drug design, that bind to a site on S100 proteins, rendering S100 incapable of inactivating p53 tumor suppressor protein. Inhibitors of S100 thus restore tumor suppressor activity of the p53 protein by inhibiting the S100-p53 interaction. Inhibitors are specific to different members of the...
Investigator(s): David Weber, Joseph Markowitz, France Carrier
Categories: Diagnostics, Therapeutics, Small molecules
Keyword(s): tumor, cancer, S100 proteins, research tools
Docket: DW-2002-041
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Method and Assay for Early Diagnosis of Prostate Cancer
Published Wednesday, May 28, 2014For well over 20 years, digital rectal examination (DRE) combined with the measurement of prostate specific antigens (PSA) have remained the most recommended screening tests for the detection of prostate cancer for men over 40. However, both exams remain highly unreliable due to the high prevalence of false positive and negative results. To...
Investigator(s): Hafiz Ahmed, Gerardo Vasta
Categories: Diagnostics
Keyword(s): prostate cancer, cancer
Docket: HA-2010-082
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Method for the identification of microbial community signature as diagnostic markers, including specific applications for the diagnosis of Crohn's disease and ulcerative colitis.
Published Wednesday, May 28, 2014The two most common forms of inflammatory bowel disease (IBD), are Crohn's and ulcerative colitis, disease states in which the body elicits an immune response within the gastrointestinal tract causing chronic pain, inflammation, and intestinal distress. Though distinctly different, the two diseases often share common symptoms making a...
Investigator(s): W. Florian Fricke, James White
Categories: Diagnostics
Keyword(s): Crohn's disease, ulcerative colitis
Docket: WF-2012-079
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Methylated Peptides Derived from Tau Protein and Their Antibodies for Diagnosis and Therapy of Alzheimer's Disease
Published Wednesday, May 28, 2014Alzheimer's disease (AD) is a neurologically degenerative disease that is defined in part by the accumulation of aberrant tau proteins (neurofibrillary tangles) within the brain. The mechanisms which drive tau aggregation is not fully understood and existing treatments do little to delay the inevitable decline of Alzheimer's patients. UMB...
Investigator(s): Jyanyu Austin Yang, Stefani N. Thomas, Jeffrey A. Kuret, Kristen E. Funk
Categories: Diagnostics, Therapeutics
Keyword(s): Alzheimer, AD
Docket: AY-2012-036
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Novel Alternatively Spliced Human Androgen Receptor Variants as Biomarkers for Prostate Cancer
Published Wednesday, May 28, 2014Prostate cancer is the second leading cause of cancer death among men in western countries. Patients with advanced prostate cancer initially benefit from androgen ablation therapy which leads to temporary remission of the tumor due to apoptosis of androgen-sensitive tumor cells. However, the recurrence of androgen-independent tumors is...
Investigator(s): Yun Qiu, Zhiyong Guo, Xi Yang
Categories: Diagnostics
Keyword(s): prostate cancer, biomarker, cancer
Docket: YQ-2008-056