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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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A Method for Monitoring Cancer and for Regulation of Semaphorin 4D to Improve Cancer Immunotherapy Regimens
Published Monday, May 14, 2018The efficacy of current cancer immunotherapies has been limited by the response of immunosuppressive elements such as myeloid derived suppressor cells (MDSC) and T regulatory cells. Understanding the mechanism behind the suppression of antitumor immunity, and finding ways to revert it, should lead to improved cancer immunotherapy outcomes....
Investigator(s): Rania Younis
Categories: Diagnostics, Biomarker, Therapeutics
Keyword(s): Semaphorin 4D, immunotherapy, oncology, head and neck, cancer
Docket: RY-2015-129
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ANALYTE-SENSITIVE PROBES AND CONTACT LENS FOR DIAGNOSIS OF OCULAR PATHOLOGIES
Published Thursday, November 9, 2023Summary The patent introduces a contact lens integrated with analyte-sensitive probes for diagnosing ocular pathologies through the detection of specific analytes in basal tears. This non-invasive, real-time monitoring technology has applications in medical diagnostics and...
Investigator(s): Joseph R. Lakowicz, Ramachandram Badugu, E. Albert Reece
Categories: Devices, Imaging devices, Diagnostics, Imaging, Healthcare
Keyword(s): Analyte-sensitive probes, fluorescence, Diagnostics, Real-time monitoring
Docket: JL-2019-091
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Biofilm Antigen-Based Diagnostic for Chronic Staph aureus Infection
Published Tuesday, August 2, 2022Chronic infections associated with implanted medical devices such as prosthetic joints are difficult to diagnose and treat due to biofilm formation by the causative pathogens. Bacterial infections often persist in the form of protective biofilms (65 - 80% of all infections), a mode of growth which reduces the effectiveness of the host immune...
Investigator(s): Rebecca Brady, Jennifer Kofonow, Timothy Vail, Jeffrey Leid, Janette Harro, & Mark Shirtliff
Categories: Diagnostics
Keyword(s): infection, diagnostic, prosthetic joint infection, Biofilm, Staphylococcus aureus
Docket: MS-2008-064
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Borrelia Burgdorferi Genetic Markers for Lyme Disease Diagnostics
Published Thursday, April 16, 2009BackgroundDiagnosing Lyme disease is notoriously difficult for physicians and veterinarians. Available tests have improved significantly over the last few decades but still leave much room for increased accuracy of results. As the genetic design of Lyme disease pathogen Borrelia burgdorferi is more fully understood, diagnostic kits may be...
Categories: Diagnostics, Biomarker
Keyword(s): Lyme Disease, Borrelia burgdorferi, B. burgdorferi, vaccine, diagnostic markers
Docket: LS-2009-015
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Clostridium difficile Type IV Pilin As New Target for Vaccine, Therapeutics and Diagnostics
Published Tuesday, May 27, 2014Type IV pilin proteins are extracellular and easily accessible to the host immune system, as well as being important for initial colonization and biofilm formation. Thus, these proteins present excellent targets for vaccines to prevent pathogen colonization. Neutralizing antibodies directed against pili could lead to...
Investigator(s): Michael Donnenberg
Categories: Diagnostics, Therapeutics, Vaccines
Keyword(s): vaccine
Docket: MD-2008-081
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Combination Assessment of Volume Status (CAVS)
Published Wednesday, May 17, 2023Early and aggressive fluid resuscitation in shock is associated with improved patient outcome and mortality. However, there is a clear correlation between cumulative fluid balance and mortality. There is, therefore, a benefit to adopting a systematic approach to fluid resuscitation to determine which patients would benefit from a fluid bolus...
Investigator(s): Sarah Murthi
Categories: Diagnostics, Software + Algorithm
Keyword(s): CAVS, shock, ultrasound, POCUS
Docket: SM-2016-067
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Compositions and Methods for Determining the Likelihood of Appendicitis
Published Tuesday, August 25, 2015Appendicitis is a condition that is easily treated through the surgical removal of the appendix. However, delays in diagnosis beyond 24-36 hours from the start of symptoms can lead to an increased risk of mortality, morbidity, and costs due to complications. Diagnosis is complicated by the heterogeneous clinical presentation of...
Investigator(s): Anthony Sandler, Claire M. Fraser, Emmanuel Mongodin, Hope Jackson, Katherine Davenport, Steven L. Zeichner
Categories: Diagnostics, Biomarker, Genomics/Proteomics/Database
Keyword(s): Appendicitis, Appendix, Microbiota, bacteria
Docket: CF-2014-074
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Defect-free dendrimer synthesis through proportionate branching
Published Tuesday, May 27, 2014Dendrimers are nanoparticles of synthetic monomers with applications in commercial paints, blood substitutes, nanomaterials, sensor technology. Dendrimers are also building blocks for targeted drug or gene delivery. The dendrimers open architecture forms hollow cavities within the branches that can encapsulate molecules such as drugs or...
Investigator(s): Bruce Yu, Xuyi Yue
Categories: Imaging devices, Diagnostics, Platforms, Therapeutics, Engineering, Biomaterials
Docket: BY-2012-068
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Defensin-like molecules as novel antimicrobial agents
Published Tuesday, May 27, 2014The ever increasing emergence of many pathogenic strains of bacteria resistant to commonly used antibiotics is a rapidly growing concern in public health and new classes of antimicrobial agents are desperately needed. One approach that has gained popularity recently is to study naturally-occurring antimicrobial peptides that have the advantage...
Investigator(s): Erik de Leeuw, Alexander MacKerell
Categories: Diagnostics, Therapeutics
Docket: ED-2012-088, ED-2010-066
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DIAGNOSIS AND PROGNOSIS OF MULTIPLE SCLEROSIS
Published Tuesday, October 31, 2023Summary: The patent introduces a novel method for determining whether an individual with relapsing-remitting multiple sclerosis (RRMS) will experience a relapse or respond positively to specific treatments. By analyzing the ratio of mRNA levels of Response Gene to Complement-32...
Investigator(s): Horea Rus, Cornelia Cudrici, Cosmin Tegla
Categories: Diagnostics, Biomarker
Keyword(s): Multiple Sclerosis, Diagnosis, Prognosis
Docket: HR-2010-081, HR-2015-030