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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Ultrasonic Guided Wave-based Structural Health Monitoring Method and Apparatus for Spinal Growing Rods
Published Monday, June 20, 2016Background:Scoliosis is the deformation or abnormal curvature of the spine and affect 2-3% of the population worldwide. In the severe cases of scoliosis, the standard of practice is to implant growing rod construct devices that straighten the patient’s spine to improve correct spinal alignment and prevent further deformation. These rods...
Categories: Bioengineering, Devices, Engineering
Keyword(s): structural health monitoring, spinal growing rod, Scoliosis
Docket: PS-2016-022
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Methods and Apparatus for Cuffless Blood Pressure Measurement
Published Monday, June 20, 2016Background:Hypertension affects ¼ of the world’s population and is a major risk factor for stroke and heart attack – two world leading causes of death. Current hypertension diagnostic resides in-clinic and is performed by the patient’s physician. With roughly 20% of hypertension patients not knowing they have it, and due to high...
Categories: Devices, Diagnostics, Bioengineering, Software + Algorithm
Keyword(s): blood pressure, hypertension, Smartphone
Docket: PS-2016-001
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Biocompatible 3D Printing Resin at Physiologic Temperature
Published Sunday, June 19, 2016BackgroundCardiovascular disease (CVD) is the leading cause of death worldwide and congenital heart disease (CHD) is among the leading causes of death in newborns. In recent years, there have been complications with the use of synthetic materials such as artificial grafts or patches, two current treatments of CVD and CHD, which include...
Categories: Engineering, Biomaterials, Bioengineering, Biological
Keyword(s): Cardiovascular disease, 3D printing, vascular graft material, 3d printer resin, drug delivery system, cell growth scaffolds
Docket: PS-2016-028
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Vaccine Enabling Technologies
Published Thursday, May 29, 2014Bacterial live vector vaccines represent a strategy offering exceptional flexibility for vaccine development. In this approach, genes that encode foreign antigens of unrelated bacterial, viral, or parasitic pathogens are expressed in an attenuated bacterial vaccine strain that delivers these foreign antigens to the immune system, thereby...
Categories: Bioengineering, Vaccine
Keyword(s): vaccine
Docket: Multiple Docket Numbers
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Injectable Matrix for Load-Bearing Bone Repair
Published Wednesday, May 28, 2014Dr. Huakun Xu and his team at UMB have created an injectable and mechanically strong construct to be used with or without stem cells for bone tissue engineering. The UMB inventors have designed a strong, moldable, and injectable stem cell-containing scaffold for bone tissue engineering that can be used in...
Investigator(s): Huakun Xu, Michael Weir
Categories: Bioengineering, Dental
Keyword(s): bone repair, dental
Docket: HX-2010-041 & HX-2012-027
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Disruption of the microtubule network as a therapeutic intervention in the muscular dystrophies
Published Tuesday, May 27, 2014Across several muscular myopathies, such as Duchenne muscular dystrophy (DMD), Becker muscular dystrophy, and dysferlinopathies, intercellular signaling cascades such as reactive oxygen signaling (ROS) and calcium (Ca2+) are enhanced and contribute to the onset and pathogenic progression of the myopathy. The discovery of the...
Investigator(s): Christopher Ward, Ramzi Khairallah
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Biologics, Engineering, Bioengineering
Keyword(s): musculoskeletal, rare disease, muscular dystrophy
Docket: CW-2012-040
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A Tunable 2- and 3-Dimensional Cell Culture Substrate for the Isolation, Enrichment, and Study of Breast Cancer Stem Cells
Published Tuesday, October 30, 2012BackgroundThe cancer stem cell hypothesis argues that a small minority of cancer cells in a heterogeneous tumor population drives the tumor growth and is responsible for the relapse and metastasis of the disease. This minority cell population, referred to as cancer stem cells (CSC) due to its stem-cell-like characteristic, has drug-resistant...
Categories: Bioengineering
Keyword(s): diagnostic medical hospital screening PSA diagnosis
Docket: PS-2012-091
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Method for Controlling Dexterous Upper Limb Neuromotor Prostheses/Orthoses with Multiple Degrees of Freedom from Neural Activity in Humans
Published Wednesday, October 3, 2012Recent developments in the fields of robotic prostheses have made it possible to build devices that mimic the human hand in its ability to manipulate multiple degrees of freedom simultaneously. These devices could be important rehabilitation tools in paralyzed patients, in patients after brain injury, or to enhance human motor performance, if...
Categories: Bioengineering
Keyword(s): Brain-Machine Interfaces, electro-encephalography (EEG)
Docket: PS-2011-027
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Method for Extracting Surface Antigens from Pathogens
Published Wednesday, October 3, 2012BackgroundOne of the greatest successes in public health in the last century has been the introduction of vaccines to prevent diseases. The mortality rate for many diseases, including smallpox, polio, diphtheria, and measles has been significantly reduced in the United States. However, the morbidity and mortality rates for some diseases...
Categories: Vaccines, Bioengineering
Keyword(s): Antigen screening, High-Throughput
Docket: LS-2011-077
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Diffusion-Based Biosensing Approach in Miniaturized Lab-on-a-Chip Devices
Published Thursday, September 6, 2012BackgroundElectrochemical impedance spectroscopy (EIS) biosensors are very sensitive to small electrochemical changes at the solid-electrolyte interface. EIS-based DNA biosensors detect any hybridization events that occur at the interface of an electrode, because such events change the total net charge at the interface of the electrode...
Categories: Bioengineering, Sensors/Monitors
Keyword(s): Diffusion, biosensor, biological, sensor, electrochemical, impedance, electrode, DNA, hybridization
Docket: PS-2011-103