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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Balanced Reach Control Systems Model
Published Tuesday, May 2, 2017Bipedal standing balance is inherently unstable and must be actively controlled to prevent falling. This involves a complex interaction of the sensorimotor system and multi-segment musculoskeletal system. Fall risk increases with deterioration of sensorimotor and musculoskeletal elements responsible for balance due to age, neurological...
Investigator(s): Joseph E. Barton
Categories: Devices, Imaging devices, Software + Algorithm, Methods of Treatment
Keyword(s): Rehabilitation, balance, reaching, Aging Population
Docket: JB-2016-005, JB-2016-004
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Bidirectional Flow Cannula
Published Thursday, January 31, 2019In order to accommodate the high blood flows in veno-arterial extracorporeal membrane circulation (VA ECMO) and cardiopulmonary bypass (CPB), large cannulae are inserted into a patient’s femoral vein, to drain blood to the system, and into the femoral artery to...
Investigator(s): Bartley Griffith, Zachary Kon, Chetan Pasrija, Mehrdad Ghoreishi, Gregory Bittle
Categories: Devices, Medical implants, Surgical devices, Methods of Treatment
Keyword(s): Cardiopulmonary, Life-support, ECMO
Docket: ZK-2017-057
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Compositions and Methods for Delivering Nucleic Acids to Cells
Published Wednesday, December 6, 2023Summary This invention provides a breakthrough in gene therapy and molecular biology, featuring a non-viral vector system for delivering nucleic acids to cells. It utilizes a polyplex particle with acetylated polyethylenimine (Ac-PEI) and an anionic biomaterial envelope, reducing...
Investigator(s): Ryan Pearson and Atanu Chakraborty
Categories: Therapeutics, Biologics, Methods of Treatment
Docket: RP-2020-012
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Compounds for Treating Parasitic Infections
Published Monday, May 15, 2023Summary Researchers at the University of Maryland, Baltimore and the University of Maryland, College Park have synthesized a new class of 1,3-thiazolidine-2,4-dione derivatives that exhibit potent activity against several protozoan parasites,...
Investigator(s): Fengtian Xue, Iqbal Hamza
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): Parsitology, infection, Immunology
Docket: FX-2015-021
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Correction of Ischemia with p53 Inhibitors: A Novel Therapeutic Approach to Induce Arteriogenesis
Published Friday, February 24, 2017Severe obstruction of the arteries and reduced blood flow (critical limb ischemia(CLI)) is the advanced stage of peripheral artery disease (PAD). Investigators at UMB have found that Pifithrin-α, a p53 pharmacological inhibitor, improves limb perfusion in diabetic animals, suggesting a therapeutic role in CLI. Tumor-suppressing...
Investigator(s): Rajabrata Sarkar, Mark Hoofnagle, Subhradip Mukhopadhyay
Categories: Therapeutics, Methods of Treatment
Keyword(s): cardiovascular
Docket: RS-2013-040
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Device and Method for Transseptal Puncture
Published Wednesday, May 17, 2023Atrial fibrillation (AF) and mitral valve (MV) disease are two of the most common cardiac conditions. AF affects between 2.7 and 6.1 million American adults each year. MV disease is the most common heart valve lesion, impacting 1.7% of U.S. adults (9.3% of people ≥ 75 years old). Both AF and...
Investigator(s): James Gammie, Rachel Quinn, Chetan Pasrija
Categories: Devices, Surgical devices, Methods of Treatment
Keyword(s): Atrial fibrilation, Mitral valve, catheter, Transseptal puncture
Docket: JG-2017-030
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Dichloroacetate and Arsenic Trioxide as an Acute Myeloid Leukemia Combination Therapy
Published Tuesday, May 16, 2017UMB research has been directed at a synergistic combination drug formulation of dichloroacetate and arsenic trioxide to treat AML. AML cells, compared to normal cells, have an increased susceptibility to the disruption of balance of oxidative forces. Selective targeting of the oxidative state, which is a tightly balanced...
Investigator(s): Ashkan Emadi, MD; Rena Lapidus, PhD
Categories: Repurpose Drug, Methods of Treatment
Keyword(s): AML; Acute Myeloid Leukemia; Combination Therapy; Arsenic Trioxide
Docket: AE-2013-045
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Functional Myelination of Neurons
Published Tuesday, May 7, 2024Summary This invention is a significant advancement in regenerative medicine, offering a novel stem cell-based therapy for demyelinating diseases. It utilizes melanocyte stem cells (MeSCs) from the skin to differentiate into cells capable of myelination, addressing diseases like...
Investigator(s): Thomas Hornyak and Sandeep Joshi
Categories: Therapeutics, Biologics, Stem Cells, Methods of Treatment
Docket: TH-2015-020
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Gallium-salophen Antimicrobial Compounds and Methods of Use Thereof
Published Wednesday, May 24, 2023Summary Pseudomonas aeruginosa (Pa), a WHO priority 1 pathogen, causes life-threatening infections. Multidrug resistant Pa has been classified by the CDC as a “serious...
Investigator(s): Fengtian Xue, Angela Wilks
Categories: Therapeutics, Small molecules, Methods of Treatment
Keyword(s): pharmaceuticals, Clinical Medicine, Antimicrobial Compounds
Docket: FX-2020-101
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Hemofiltration device, system and method for a high blood flow extracorporeal circuit
Published Thursday, May 25, 2023Summary The disclosed invention describes a hemofiltration device, system, and method designed for high blood flow extracorporeal circuits. This technology overcomes the limitations of conventional renal replacement therapy (...
Investigator(s): Alison Grazioli, Joseph Rabin, Ronson Madathil, Rashmikant Shah
Categories: Devices, Methods of Treatment
Keyword(s): Hemofiltration, High Blood Flow, Extracorporeal Circuit, Renal Replacement Therapy
Docket: AG-2019-016