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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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A Probabilistic Acoustic-Phonetic Approach to Automatic Speech Recognition
Published Wednesday, September 1, 2004The state of the art voice recognition systems use very little knowledge of acoustic-phonetics and are largely dependent on statistical modeling.This invention, brings together knowledge of acoustic-phonetics and statistical pattern recognition to build a system, called Event-Based System (EBS) for automatic speech recognition. The...
Categories: Information Technology
Keyword(s): voice recgonition, phonetics, speech recognition, learn
Docket: IS-2004-010
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A Probiotic Strain For Nutritional and Therapeutic Use
Published Wednesday, April 12, 2017Background Probiotics- single or mixed cultures of live microorganisms with the ability to confer health benefits to host upon dietary consumption- emerged as functional foods with enormous market potential (>$4-5 billion). Several products with such live cultures are currently available in the marketplace. However, susceptibility to viral...
Keyword(s): probiotics, phage-resistant, normal flora, pathogenic bacteria
Docket: LS-2016-124
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A Process for 3-Dimensional Micro Mechanisms
Published Sunday, July 9, 2000Many curent technologies for producing non-planar microstructures such as LIGA, deep reactive ion etching and laser etching result in simple extrusions of 2-dimensional planar surfaces. Some prior art methods that do generate 3-dimensional micro-devices, such as component bonding and hinged structure fabrication, require manual assembly and thus...
Categories: Industrial Processing
Keyword(s): MEMS, micrelectronic devices, micro structures
Docket: PS-98-007
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A Process for Coating Biological Pesticides and Compositions Therefrom
Published Tuesday, October 31, 2000Baculoviruses are known biological materials having insecticidal activity. The commercial utility of these materials has been limited though because, without special formulation, like most biological materials are readily deactivated by the UV radiation in sunlight.The incorporation of UV protectants in a variety of ways is known and...
Keyword(s): biopesticide, Baculovirus, TiO2
Docket: DD-2000-064
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A Rapid Method for Scanning Amino Acid Mutagenesis
Published Tuesday, April 14, 2009In order to study the relationship between structure and function of a protein, the DNA encoding the protein or its corresponding amino acid is subjected to mutations. A number of methods to mutagenize DNA have been developed including site-directed mutagenesis, linker scanning mutagenesis, and the alanine scanning mutagenesis. The first method...
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): mutagenisis, mutation, DNA, amino acid, nucleotide, protein
Docket: LS-2007-026
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A Reliable, High-Yield Method to Grow Uniform Epitaxial Graphene Precursor Layer on SiC
Published Tuesday, July 17, 2018Background:The global market for graphene based products is projected to be 2 billion dollars after the year 2020 at an annual growth rate of 46.3 %. This trend is mainly attributable to graphene’s unique combination of electrical, optical, and mechanical properties, which makes it a top contender for ultra-small, ultra-fast electronics...
Keyword(s): Epitaxial graphene
Docket: PS-2018-015
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A Repurposed Use for an FDA Approved Drug to Combat Tuberculosis and Gut Pathogens
Published Monday, February 26, 2018Background As of 2015, the World Health Organization (WHO) estimates there are about 10.4 million people who fell ill due to tuberculosis (TB). Current treatment course includes a multiple-drug regimen for 2 months followed by a 4 month course with fewer medicines. The emergence of drug resistant strains of the bacterium due to longer...
Keyword(s): 525
Docket: LS-2017-038
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A Revolutionary Touch Screen Interface for NewsStand
Published Sunday, February 20, 2011Smartphones—from Blackberries to iPhones to Androids—have revolutionized the way we access information. The latest news updates are only a few clicks away even if we are out and about. Similarly, mapping and navigational applications have changed how we interface with the world. A quick scroll moves us up from street level—city grids, states,...
Categories: Information Technology
Keyword(s): smartphone, touch screen, news, map-query interface
Docket: IS-2010-114
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A Stable Fibroblast Cell Line To Study Innate Immunity and Host-Viral Interactions
Published Monday, January 28, 2019Background Pathogenic viral infection induced host responses are often driven by specific molecules like interferons. Specific recognition of viral nucleic acids serves as a trigger to stimulate expression of interferons. An essential transcription factor for interferon expression interferon regulatory factor-3 (IRF3) is present in the...
Keyword(s): 525
Docket: LS-2019-002
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A stable Receptor-Associated Protein (RAP) protein
Published Tuesday, September 22, 2015A novel Stable Receptor-Associated Protein (RAP), an antagonist of lipoprotein receptor-related protein 1 (LRP1). Dr. Strickland at UMB has developed a stable RAP D3 domain (with 6 mutations) that is resistant to both pH- and heat-induced denaturation. The molecule binds to lipoprotein receptor-related protein 1 (LRP1) with high affinity...
Investigator(s): Dudley Strickland
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): RAP Protein stable
Docket: DS-2015-111