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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Anti-shark IgNar mouse monoclonal (GA8) antibody
Published Tuesday, September 22, 2015The cartilaginous fish (sharks, skates, and rays) have a human-type adaptive immune system as well as immunoglobulins (Igs). In addition to the heavy-light chain heterodimeric isotypes (IgM and IgW), sharks also produce a novel isotype called IgNAR. IgNAR is a heavy chain homodimer that does not associate with light chains....
Investigator(s): Martin Flajnik
Categories: Research Tools, Antibodies, & Reagents
Docket: MF-2009-077
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Antibacterial monomers, antibacterial resins and dental composites comprising the antibacterial resins
Published Thursday, October 15, 2015A major clinical problem associated with dental restorations is secondary cary formation and tooth restoration fractures. To address this issue, a new dental resin developed at the University of Maryland, Baltimore, was created that possesses superior mechanical strength and antimicrobial properties. The formulation...
Investigator(s): Huakun Xu, Michael Weir
Categories: Dental
Keyword(s): dental, cary, restorative, composite
Docket: HX-2013-023
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Anticancer Compounds Targeted at Secondary DNA Structures
Published Monday, November 24, 2014BackgroundWhile the structure of DNA is most commonly associated with the double helix, research has shown that DNA can adopt many secondary structures for which the biological functions are still being determined. One secondary structure, the G-quadruplex, can form when the double helix unwinds during transcription. One common area for...
Categories: Small molecules
Keyword(s): FLT-3 inhibitor, PARP inhibitor, ALL, ALM, TNBC,
Docket: LS-2014-104
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Antimicrobial Heme Oxygenase Inhibitors and Methods of Use
Published Tuesday, May 27, 2014Antimicrobials are widely used to treat a variety of infections. However, due to overuse and microbial evolution, many antimicrobials are rendered ineffective as first-line therapies. This invention is a new class of broad-spectrum, small-molecule antimicrobials that target the critical enzyme, heme oxygenase that is required to process...
Investigator(s): Angela Wilks, Alexander D. MacKerell, Pedro Lopes, Lena M. Furci
Categories: Therapeutics, Small molecules
Keyword(s): antimicrobial, treatment
Docket: AW-2007-003
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Apparatus for Measuring Absolute Complex Conductivity and Surface Impedance of Metals and Superconductors
Published Tuesday, March 9, 1999Knowledge of the skin depth and surface resistance is important for accurate measurements of material conductivity. Knowledge of surface impedance and dielectric properties of materials at microwave frequencies is of increasing importance as the clock rates of computers exceed 1 GHz, the density of magnetic recording media continue to increase,...
Categories: Microelectronics, Research Tools, Antibodies, & Reagents
Keyword(s): skin depth and surface resistance measurements,microwave frequency, thin film
Docket: PS-98-048
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Apparatus for Microarray DNA Binding Sensors Using Electronic Detection of Nucleic Acid Hybridization
Published Wednesday, April 18, 2007DNA microarrays are powerful tools for high throughput monitoring of gene expression at the transcription level, determining genome wide DNA copy changes, identifying targets of transcription factors, sequencing and more recently for profiling of the micro RNA (miRNA) levels in cancer. Currently existing methods rely upon various combinations of...
Categories: Nanotechnology + Nanoparticles + Nanomaterials
Keyword(s): DNA hybridization, Microarray gene expression, 525
Docket: PS-2006-020
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Application A: Novel Strategy to Regulate Inflammation; Application B: Novel Strategy to Facilitate Intracellular Delivery of Drugs Regardless of the Drug or Drug Carrier Geometry.
Published Wednesday, January 25, 2012For Application A: Novel Strategy to Regulate InflammationExecutive SummaryBackgroundInflammation involves migration of white blood cells or leukocytes from the circulation into tissues across a thin cell layer of cells (endothelial cells) that covers the inner wall of blood vessels. There are two recognized pathways...
Keyword(s): inflammation, cardiovascular disorders, inflammation regulation, intracellular drug delivery, drug delivery, acute lung injury, atherosclerosis, diabetes, hypertension, autoimmune diseases
Docket: LS-2010-107
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Arabic Variant Identification Aid (AVIA)
Published Wednesday, March 18, 2009This invention’s entire package is called the Arabic Variant Identification Aid (AVIA). It consists of a manual of 7 colloquial Arabic dialects that describes their key linguistic features and highlights the ways in which they differ from each other, as well as from Modern Standard Arabic. The AVIA is a reference source that is designed...
Categories: Education/Training/Multimedia
Keyword(s): Arabic language variant identification
Docket: IS-2007-065
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Assessing Biopharmaceutical Aggregation Using Magnetic Resonance Relaxometry
Published Tuesday, May 27, 2014Aggregation is a significant problem in biopharmaceutical manufacturing and long-term storage, as aggregated proteins may lose their biological activities, alter concentration, distribution, and kinetics, and aggravate immunogenicity. As the number of biomacromolecule-based, nanoparticle-conjugated, and non-biological...
Investigator(s): Yihua Bruce Yu, Marc Taraban, Yue Feng
Categories: Other
Keyword(s): Quality Control, Biopharmaceutical, diagnostic
Docket: BY-2013-101
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Assessment of Ability to Perceive Linguistic Tone
Published Monday, April 9, 2018ALTA is a supplemental aptitude battery designed to measure an individual's ability to learn a tone language. This battery includes: 1) several short behavioral tests; 2) measures of general cognitive abilities; and 3) background information regarding previous language history and musical experiences.
Keyword(s): 525
Docket: IS-2014-129