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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Methods for Regulating Urinary Potassium
Published Wednesday, May 28, 2014Potassium is the most abundant intracellular cation. It is critically important for many physiologic processes, including maintenance of cellular membrane potential, homeostasis of cell volume, and transmission of action potentials in nerve cells. Small changes in the extracellular potassium level can have profound effects on the function of...
Investigator(s): Paul Welling, Liang Feng
Categories: Therapeutics, Small molecules, Biologics
Keyword(s): Urinary Potassium, potassium
Docket: PW-2008-072
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Melanoma Oncolytic Virotherapy by the HSV-2 Mutant delta-PK
Published Wednesday, May 28, 2014Oncolytic viruses are replication-conditional viruses with relative tumor selectivity and are a therapeutic strategy designed to reduce tumor burden by direct cell lysis; however, their modest clinical efficacy may be related to poor virus replication within the tumors. The present invention is based on the hypothesis that virotherapy...
Investigator(s): Laure Aurelian, Aric Colunga, Jennifer Laing
Categories: Therapeutics, Biologics
Keyword(s): Melanoma, Virotherapy
Docket: LA-2009-096
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TLR Inhibitors for Treatment of Influenza, Cancer, Allergy, Inflammation and Prevention of Endotoxic Shock
Published Wednesday, May 28, 2014The Toll-like receptors (TLRs) play a vital role in eradicating pathogenic microbial infections, eliminating necrotic host cells and enhancing tissue repair in the host. On the flip side, chronic TLR activation leads to inflammatory disease and “systemic” activation of TLRs may lead to death. ...
Investigator(s): Vladimir Toshchakov
Categories: Research Tools, Antibodies, & Reagents, Platforms, Therapeutics, Biologics
Keyword(s): TLR, decoy peptides, inflammation, cancer, microbial infections, immune disorders, allergy, endotoxic shock, TRAM, TRIF, TIRAP and MyD88
Docket: VT-2012-029 VT-2012-052
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Inhibition of Breast Cancer Metastases using Natural Extracts from Colocasia Esculenta (Taro).
Published Wednesday, May 28, 2014Studies link breast cancer, the second leading cause of cancer-related mortality in US women, with the occurrence of metastatic disease and spread. However, the majority of current therapies focus on the treatment of solid tumors with very little focus on targeting the metastatic process. Due to the significant correlation of secondary tumors...
Investigator(s): Namita Kundu, Amy Fulton
Categories: Therapeutics, Biologics, Natural Compounds
Keyword(s): breast cancer, cancer
Docket: NK-2009-001
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IL-25 treatment of obesity and metabolic disorders
Published Tuesday, May 27, 2014Obesity is associated with chronic low grade inflammation in adipose tissues, mainly due to the accumulated immune cells (Th1/Th17 cells, macrophages etc.) that release pro inflammatory cytokines into the system. These cytokines contribute to development of the “metabolic syndrome.” IL-25 is an important regulator in the...
Investigator(s): Aiping M. Zhao, Terez Shea-Donohue
Categories: Therapeutics, Biologics
Keyword(s): IL-25, Biologic, Therapeutic
Docket: AZ-2011-020
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Disruption of the microtubule network as a therapeutic intervention in the muscular dystrophies
Published Tuesday, May 27, 2014Across several muscular myopathies, such as Duchenne muscular dystrophy (DMD), Becker muscular dystrophy, and dysferlinopathies, intercellular signaling cascades such as reactive oxygen signaling (ROS) and calcium (Ca2+) are enhanced and contribute to the onset and pathogenic progression of the myopathy. The discovery of the...
Investigator(s): Christopher Ward, Ramzi Khairallah
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Biologics, Engineering, Bioengineering
Keyword(s): musculoskeletal, rare disease, muscular dystrophy
Docket: CW-2012-040
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