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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Research Tool for Identification of Conditionally Enriched Protein Expression in Bacterial Cells
Published Tuesday, September 22, 2015BackgroundChanges in environmental conditions can drastically change the protein content of cells. The amount of specific proteins (i.e., their expression levels) can increase or decrease quickly in response to these environmental changes in order to insure cell survival. This rapid process happens at the translational and post-...
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): 525
Docket: LS-2015-092
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Anti-shark IgNar mouse monoclonal (GA8) antibody
Published Tuesday, September 22, 2015The cartilaginous fish (sharks, skates, and rays) have a human-type adaptive immune system as well as immunoglobulins (Igs). In addition to the heavy-light chain heterodimeric isotypes (IgM and IgW), sharks also produce a novel isotype called IgNAR. IgNAR is a heavy chain homodimer that does not associate with light chains....
Investigator(s): Martin Flajnik
Categories: Research Tools, Antibodies, & Reagents
Docket: MF-2009-077
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A stable Receptor-Associated Protein (RAP) protein
Published Tuesday, September 22, 2015A novel Stable Receptor-Associated Protein (RAP), an antagonist of lipoprotein receptor-related protein 1 (LRP1). Dr. Strickland at UMB has developed a stable RAP D3 domain (with 6 mutations) that is resistant to both pH- and heat-induced denaturation. The molecule binds to lipoprotein receptor-related protein 1 (LRP1) with high affinity...
Investigator(s): Dudley Strickland
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): RAP Protein stable
Docket: DS-2015-111
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Anti-GRIM-19 antibody
Published Thursday, May 7, 2015Anti-GRIM-19 (1A8) is a mouse monoclonal antibody for detecting Retinoic-Interferon-induced Mortality 19 (GRIM-19) protein. This antibody was raised against the recombinant human GRIM-19 and can recognize both human and mouse GRIM-19. GRIM-19 is widely expressed in humans, with highest expression in heart, skeletal muscle, liver, kidney...
Investigator(s): Dhan V. Kalvakolanu
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): grim, antibody, tumor suppressor, COPD, carcinoma
Docket: DK-2003-050
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Tight junction permeation enhancer peptides
Published Monday, March 23, 2015Human zonulin or pre-haptoglobin 2 (HP2) is known to reversibly regulate intestinal permeability by modulating intercellular tight junctions. Itactivates protease-activated receptor (PAR) 2, and induces signaling...
Investigator(s): Alessio Fasano, Stefanie N. Vogel
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Small molecules, Biologics, Methods of Treatment
Keyword(s): peptides, zot, zonulin, crohns asthma, glioma, celiac disease, type I diabetes, tight junction
Docket: AF-2004-004
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Use of Omentin for Treatment and Prediction of Disease
Published Wednesday, January 28, 2015Obesity, especially accumulation of abdominal fat, is a risk factor for the development of type 2 diabetes and cardiovascular disease. More than one-third of US adults are considered to be obese. Omentin is an adipokine expressed and secreted from abdominal but not subcutaneous...
Investigator(s): Da-Wei Gong, Alan Shuldiner, John McLenithan, Rongze Yang
Categories: Research Tools, Antibodies, & Reagents, Diagnostics, Therapeutics, Biologics, Biomaterials
Keyword(s): omentin, diabetes, obesity, cardiovascular
Docket: DG-2002-013, DG-2007-087, DG-2009-093
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High Affinity PCR Primer System
Published Tuesday, November 4, 2014BackgroundPolymerase chain reaction (PCR) is a biological research technique for the amplification of DNA sequences that has allowed for great advances in genetics. While PCR techniques have been refined over the years, and there has been continued development of the polymerases used in PCR, there are still some limitations to the...
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): Genetic testing, PCR primers
Docket: LS-2014-045
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3D Printed Molds for 3D Tissue Culture Scaffolds
Published Tuesday, November 4, 2014BackgroundCellular and tissue culture is an important aspect of biological research. Having specific cell or tissue types in a controlled environment allows for development and refinement of the efficacy and safety of biological treatments. However, as researchers study more complex conditions, standard monolayer (2D) cell culture is...
Categories: Biological, Research Tools, Antibodies, & Reagents
Keyword(s): PDMS, stem cells, cell culture, tissue culture
Docket: LS-2014-073
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Microdevice for the Detection of Sequence Differences in Biological Samples
Published Tuesday, November 4, 2014BackgroundWith the advancements in biomedical research, accurate sequencing of biological samples is becoming of greater importance. The completion of the Human Genome Project has highlighted the potential of single nucleotide polymorphisms (SNPs) in DNA while the increase in protein-based therapies has increased interest in the...
Categories: Diagnostics, Devices, Research Tools, Antibodies, & Reagents
Keyword(s): Gene sequencing, protein sequencing, lab-on-chip
Docket: LS-2014-076
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Simplified Synthesis of Polyubiquitin Chains
Published Sunday, July 20, 2014BackgroundUbiquitin is an important protein involved in the post-translational modification and trafficking of other cellular proteins. After attaching a single ubiquitin monomer to a protein, cells use the formation of polyubiquitin chains (attaching more ubiquitin to the initial monomer) to direct if the protein should be inserted into...
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): Ubiquitin synthesis
Docket: LS-2014-029