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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Use of ELA peptide for treatment of cardiovascular disease and for improving fluid homeostasis
Published Tuesday, October 20, 2015Cardiovascular disease (CVD) continues to be one of America’s most serious and costly health issues. Though many therapeutic options exist to treat CVD, the majority of treatments address the symptoms of the disease and not the disease itself. This technology is a new class of therapeutic fusion proteins using the hormone Elabela (ELA) to...
Investigator(s): Da-Wei Gong (Lead PI)
Categories: Therapeutics, Biologics, Methods of Treatment
Keyword(s): MI, peptide, heart failure, myocardial infarction, cardiovascular, obesity, ELA, apelin
Docket: DG-2014-128
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Protein-Coated Microspheres for the Treatment of Inflammatory Bowel Conditions
Published Tuesday, June 30, 2015Chronic inflammation of the bowel is estimated to affect over 20% of Americans with only a small subset of individuals being clinically diagnosed with the autoimmune diseases Crohn’s and ulcerative colitis (UC). Researchers at the University of Maryland, Baltimore have developed a targeted therapeutic approach that may be...
Investigator(s): Erik P.H. de Leeuw; Wuyuan Lu
Categories: Therapeutics, Biologics, Methods of Treatment
Keyword(s): microsphere, defensin, inflammatory bowel syndrome, inflammatory bowel disease, Crohn's disease, ulcerative colitis, surface-like protein
Docket: ED-2010-131
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Tight junction permeation enhancer peptides
Published Monday, March 23, 2015Human zonulin or pre-haptoglobin 2 (HP2) is known to reversibly regulate intestinal permeability by modulating intercellular tight junctions. Itactivates protease-activated receptor (PAR) 2, and induces signaling...
Investigator(s): Alessio Fasano, Stefanie N. Vogel
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Small molecules, Biologics, Methods of Treatment
Keyword(s): peptides, zot, zonulin, crohns asthma, glioma, celiac disease, type I diabetes, tight junction
Docket: AF-2004-004
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Zona Incerta Stimulation for Chronic Pain Relief
Published Thursday, May 29, 2014Central pain syndrome (CPS) is a debilitating condition affecting with lesions or dysfunction in the central nervous system. CPS is a neurological disorder resulting from damage to or dysfunction of the pain-conducting pathways of the central nervous system. The patented invention describes a novel method for treating CPS regions of the...
Investigator(s): Asef Keller, Raimi Quiton, Peter Murray, Radi Masri, Jessica Lucas
Categories: Devices, Methods of Treatment
Keyword(s): chronic, pain, device, neurostimulation
Docket: AK-2009-044
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