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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Xv1 Inhibition As A Novel Antimitotic Cancer Therapy
Published Thursday, July 7, 2022Mitosis has been an attractive target for anti-cancer therapies given that uncontrolled cell division is one of the key hallmarks of cancer. However, some normal cells like hematopoietic progenitor cells (HPCs), also undergo rapid cell division. Therefore, nearly all current cell cycle-targeted drugs are limited by their severe toxicity to such...
Investigator(s): Shengyun Fang, Yongwang Zhong
Keyword(s): cancer, Cancer Therapy, Targeted Therapy, XBP1, Xv1
Docket: SF-2020-011
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ZAP-70 As Biomarker and Immune System Modulator
Published Thursday, May 29, 2014The body's immune system is characterized by its ability to rapidly respond to foreign antigens (part of a bacterial or cancer cell, for example) that were previously encountered. This rapid response is mediated by memory T lymphocytes. When these cells are activated, they produce effector cytokines, such as TNF-alpha and IFN-gamma, which...
Investigator(s): Donna Farber, Francesca Okoye, Meena Chandok
Keyword(s): immune system, T cell, biomarker
Docket: DF-2008-006
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Zona Incerta Stimulation for Chronic Pain Relief
Published Thursday, May 29, 2014Central pain syndrome (CPS) is a debilitating condition affecting with lesions or dysfunction in the central nervous system. CPS is a neurological disorder resulting from damage to or dysfunction of the pain-conducting pathways of the central nervous system. The patented invention describes a novel method for treating CPS regions of the...
Investigator(s): Asef Keller, Raimi Quiton, Peter Murray, Radi Masri, Jessica Lucas
Categories: Devices, Methods of Treatment
Keyword(s): chronic, pain, device, neurostimulation
Docket: AK-2009-044
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‘Sashi’ Agar- Agar for the Specific Detection of Salmonella and Shigella
Published Sunday, November 12, 2006Researchers have developed a single plating agar that detects both Shigella and Salmonella species. Importantly, the new agar is capable of doing this with greater sensitivity and specificity, for both agents, than other agars in common use. The new agar, because of its ability to efficiently detect two major human pathogens, appears to...
Categories: Research Tools, Antibodies, & Reagents
Keyword(s): Microbiological media, agar, Salmonella, shigella
Docket: LS-2006-034