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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Defect-free dendrimer synthesis through proportionate branching
Published Tuesday, May 27, 2014Dendrimers are nanoparticles of synthetic monomers with applications in commercial paints, blood substitutes, nanomaterials, sensor technology. Dendrimers are also building blocks for targeted drug or gene delivery. The dendrimers open architecture forms hollow cavities within the branches that can encapsulate molecules such as drugs or...
Investigator(s): Bruce Yu, Xuyi Yue
Categories: Imaging devices, Diagnostics, Platforms, Therapeutics, Engineering, Biomaterials
Docket: BY-2012-068
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Disruption of the microtubule network as a therapeutic intervention in the muscular dystrophies
Published Tuesday, May 27, 2014Across several muscular myopathies, such as Duchenne muscular dystrophy (DMD), Becker muscular dystrophy, and dysferlinopathies, intercellular signaling cascades such as reactive oxygen signaling (ROS) and calcium (Ca2+) are enhanced and contribute to the onset and pathogenic progression of the myopathy. The discovery of the...
Investigator(s): Christopher Ward, Ramzi Khairallah
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Biologics, Engineering, Bioengineering
Keyword(s): musculoskeletal, rare disease, muscular dystrophy
Docket: CW-2012-040
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Novel Filamentous Hyperstable Chaperone with Protein and Cellular Stabilization
Published Wednesday, May 28, 2014Ethanol, butanol, acetone and many other chemicals have traditionally been employed as a chemical feed stock for a variety of industrial chemicals. However, many of the byproducts produced during fermentation is cytotoxic and limits product generation. The disadvantages of low productivity, low cell density, longer fermentation, and prolonged...
Investigator(s): Frank Robb, Pongpan Laksanalamai, Anchalee Jiemjit, Douglas Clark, Timothy Whitehead
Categories: Engineering, Chemical
Docket: FR-2010-088
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Thermostabilization of DNA Polymerase with Novel Chaperones
Published Thursday, May 29, 2014Dr. Frank Robb has considerable expertise in the study of microbes found in extreme environments and their mechanisms of survival. These astonishing organisms have protein chaperone systems that enable them to survive and even thrive in extreme heat and harsh chemical conditions. An important application for these chaperones is to enhance...
Investigator(s): Frank Robb, Pongpan Laksanalamai
Categories: Research Tools, Antibodies, & Reagents, Engineering, Chemical
Docket: FR-2010-087
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Fiber Tip Based Fiber Optic Sensor Systems
Published Tuesday, August 27, 2002Design and control of complex structural and mechanical systems such as household appliances, aircraft, automobiles, underwater vehicles, and theaters requires acoustic and structural vibration analysis. Vibrations may be the source of a noisy environment and/or the cause of fatigue damage, as in the case of automobiles, aircraft, and ships...
Categories: Microelectronics, Engineering, Sensors/Monitors
Keyword(s): fiber tip, optical sensor, Fabry-Perot, acoustic, accelerometer, microphone, optical phase, interference pattern, homeland
Docket: PS-2002-044
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Optical Interconnect Using a Small Number of Layers
Published Tuesday, May 10, 2005The present invention relates to an optical interconnect fabric operating deep inside a computer system to provide optical co`mmunication between processing elements and memory cells of first level cache.To that effect, the invention is a multi-chip processor/memory arrangement replacing a large computer chip that includes a number of...
Categories: Engineering, Microelectronics
Keyword(s): all optical, 525
Docket: PS-2003-019
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Frequency and Force Modulation Atomic Force Microscopy
Published Thursday, March 6, 2008Amplitude-modulation tapping-mode atomic force microscopy (AM-AFM) has developed into an important imaging tool for surface characterization. Despite its technical advances it succumbs to imaging bistability caused by the co-existence of attractive and repulsive imaging regimes, and potential sample damage in the repulsive regime....
Categories: Sensors/Monitors, Devices, Engineering
Keyword(s): atomic force microscopy
Docket: PS-2007-001
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Novel Polymer Solid Electrolyte for Flexible Batteries
Published Wednesday, April 2, 2008Batteries used in medical equipment and implants are part of a one billion dollar worldwide market in which supply has not yet reached demand. Lithium ion polymer batteries, due to their superior energy density, small size, and low toxicity, are well-suited as medical implant power sources. These batteries circumvent the use of corrosive and...
Categories: Clean Technology, Engineering, Chemical, Power Electronics
Keyword(s): polymer, electrolyte, battery, energy source
Docket: PS-2008-013
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Waterfall Cooling and Heating Systems
Published Wednesday, April 23, 2008This invention provides cooling and dehumidification during hot and humid conditions and heating and humidification during cold and dry conditions. While conventional decorative waterfalls provide humidity to dry air winter spaces, they add to humidity levels during the summer. Conventional vapor compressor systems provide heating and cooling...
Categories: Clean Technology, Engineering, Chemical, Industrial Processing
Keyword(s): water fall cooling heatng system
Docket: PS-2007-110
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Integrated CMOS Capacitance Sensors for On-Chip Tracking of Cell Proliferation
Published Tuesday, April 29, 2008Quantifying cell growth is essential for many applications in cell biology and biotechnology. It is required for optimizing cell culture conditions, for studying substances that inhibit or promote cell growth, for studying cancer progression, cytotoxicity assessment, biocompatibility characterization, etc. Traditional cell proliferation assays...
Categories: Engineering, Sensors/Monitors
Keyword(s): CMOS, cancer, on chip, proliferation, cell growth, capacitance, sensor
Docket: PS-2008-047