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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Water Proton NMR for Monitoring Sedimentation Process of Multiphase Mixtures
Published Tuesday, June 27, 2023Summary The technology developed by the University of Maryland, Baltimore utilizes water proton Nuclear Magnetic Resonance (NMR) to monitor the sedimentation process in multiphase mixtures in real-time. This analytical method...
Investigator(s): Bruce Yu, Marc Taraban
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Small molecules, Chemicals, Biologics, Vaccines
Keyword(s): Sedimentation Monitoring, Multiphase Mixtures, Water Proton NMR, Pharmaceutical, Specialty Chemical, Specialty Materials
Docket: BY-2020-149
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Real Time in-situ Monitoring of Drug Product Degradation Using Water Proton NMR
Published Wednesday, May 17, 2023Summary This technology uses NMR spectroscopy to measure changes in the NMR signal of water, which is sensitive to changes in the chemical environment of the drug molecules it interacts with. This patented method allows for...
Investigator(s): Bruce Yu, Marc Taraban, Katharine Briggs
Categories: Devices, Diagnostics, Therapeutics, Small molecules, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze-Thaw
Docket: BY-2020-079
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Noninvasive Quantitation of Full Versus Empty Capsids Using Water Proton NMR
Published Wednesday, May 17, 2023Summary This invention proposes a method for using NMR relaxation rates to determine whether capsid preparations contain empty or full viral capsids and to quantify the capsid content of the preparation....
Investigator(s): Bruce Yu, Marc Taraban
Categories: Devices, Diagnostics, Therapeutics, Small molecules, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze Thaw
Docket: BY-2020-059
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Detection of Pharmaceutical Product Freezing History using Water Proton NMR
Published Wednesday, May 17, 2023Summary Researchers at UMB have created an innovative method that employs water proton nuclear magnetic resonance (NMR) spectroscopy to detect the freezing history of pharmaceutical products. This technology compares the...
Investigator(s): Bruce Yu, Marc Traban, Katharine Briggs
Categories: Devices, Therapeutics, Biologics, Vaccines, Vaccine, Other
Keyword(s): NMR, Quality Control, vaccine, Drug Manufacturing, Freeze-Thaw
Docket: BY-2019-081
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PSA peptides for prostate cancer immunotherapy
Published Wednesday, May 28, 2014Prostate Specific Antigen (PSA) is a protein produced solely by prostate tissue, including tumors, and is considered a promising target for development of a prostate cancer vaccine. In fact, other groups are currently developing candidate vaccines focused on Class I-restricted CD8+ T-cell immunity, but the ultimate success of those efforts is...
Investigator(s): Richard Alexander, Elena Klyushnenkova, Arthur Vandenbark, Jason Link
Categories: Therapeutics, Biologics, Vaccines
Keyword(s): prostate cancer
Docket: RA-2004-035