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Researchers at the University of Maryland have created hundreds of innovations that are available for licensing. Our Discovery Portfolio contains an exciting mix of vaccines, drug targets, therapeutics, devices and cutting edge techniques that promise to make a quantifiable impact on human health and the environment.
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Thermostabilization of DNA Polymerase with Novel Chaperones
Published Thursday, May 29, 2014Dr. Frank Robb has considerable expertise in the study of microbes found in extreme environments and their mechanisms of survival. These astonishing organisms have protein chaperone systems that enable them to survive and even thrive in extreme heat and harsh chemical conditions. An important application for these chaperones is to enhance...
Investigator(s): Frank Robb, Pongpan Laksanalamai
Categories: Research Tools, Antibodies, & Reagents, Engineering, Chemical
Docket: FR-2010-087
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Novel Filamentous Hyperstable Chaperone with Protein and Cellular Stabilization
Published Wednesday, May 28, 2014Ethanol, butanol, acetone and many other chemicals have traditionally been employed as a chemical feed stock for a variety of industrial chemicals. However, many of the byproducts produced during fermentation is cytotoxic and limits product generation. The disadvantages of low productivity, low cell density, longer fermentation, and prolonged...
Investigator(s): Frank Robb, Pongpan Laksanalamai, Anchalee Jiemjit, Douglas Clark, Timothy Whitehead
Categories: Engineering, Chemical
Docket: FR-2010-088
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Disruption of the microtubule network as a therapeutic intervention in the muscular dystrophies
Published Tuesday, May 27, 2014Across several muscular myopathies, such as Duchenne muscular dystrophy (DMD), Becker muscular dystrophy, and dysferlinopathies, intercellular signaling cascades such as reactive oxygen signaling (ROS) and calcium (Ca2+) are enhanced and contribute to the onset and pathogenic progression of the myopathy. The discovery of the...
Investigator(s): Christopher Ward, Ramzi Khairallah
Categories: Research Tools, Antibodies, & Reagents, Therapeutics, Biologics, Engineering, Bioengineering
Keyword(s): musculoskeletal, rare disease, muscular dystrophy
Docket: CW-2012-040
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Defect-free dendrimer synthesis through proportionate branching
Published Tuesday, May 27, 2014Dendrimers are nanoparticles of synthetic monomers with applications in commercial paints, blood substitutes, nanomaterials, sensor technology. Dendrimers are also building blocks for targeted drug or gene delivery. The dendrimers open architecture forms hollow cavities within the branches that can encapsulate molecules such as drugs or...
Investigator(s): Bruce Yu, Xuyi Yue
Categories: Imaging devices, Diagnostics, Platforms, Therapeutics, Engineering, Biomaterials
Docket: BY-2012-068